Early-onset familial hypoaldosteronism
MONDO:0035320A rare type of familial hypoaldosteronism characterized by early infantile onset of vomiting, diarrhea, severe dehydration, and failure to thrive. Analysis of plasma electrolytes shows hyponatremia, hyperkalemia, and acidosis. Plasma renin activity is elevated, and aldosterone levels are low.
Also known as: Early-onset familial hyperreninemic hypoaldosteronism, Severe aldosterone synthase deficiency
3 clinical trials for this condition and its sub-types.
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Hidden hormone disorders may explain salt loss in newborns
Knowledge-focused Recruiting nowThis study looks at newborns who lose too much salt due to rare hormone problems that can be mistaken for a more common condition called congenital adrenal hyperplasia. Researchers want to find out how often these rare conditions happen and describe their symptoms, genetics, and …
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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New imaging tracer could shed light on adrenal cholesterol
Knowledge-focused Recruiting nowThis study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …
Early phase 1 • Sponsor: Benjamin Viglianti • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC