Dravet syndrome
MONDO:0100135Dravet syndrome is a channelopathy with epilepsy of with onset during the first year of life, typically 4-5 months, characterized by status epilepticus and a variety of drug-resistant seizures often induced by fever, presenting in previously healthy children, and which frequently leads to cognitive and motor impairment. Dravet differs from other channelopathies usually due to a mutation in SCN1A.
Also known as: DS, Dravet, Dravet syndrome, SME, SMEB, myoclonic epilepsy, severe, of infancy, severe myoclonic epilepsy of infancy
46 clinical trials for this condition and its sub-types.
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Study tests safer switch from street CBD to approved drug for kids with severe epilepsy
Disease control Not yet recruitingThis study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…
Phase: PHASE4 • Sponsor: Elizabeth Donner • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Wearable EEG gadget aims to perfect seizure drug dosing at home
Knowledge-focused Not yet recruitingThis study tests whether a wearable device that records brain waves, heart rate, and movement at home can help doctors better adjust the dose of the seizure drug fenfluramine for people with Dravet syndrome or Lennox-Gastaut syndrome. Twenty patients will wear the device for 3-7 …
Phase: NA • Sponsor: Byteflies • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC