Demyelinating disease
MONDO:0002562A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.
Also known as: demyelinating disorder
931 clinical trials for this condition and its sub-types, 27 tagged with Demyelinating disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Demyelinating disease
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Demyelinating disease of central nervous system 4 trials · 860 incl. sub-types
2 sub-types
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
- Myelin oligodendrocyte glycoprotein antibody-associated disease 22 trials Sub-types →
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Polyradiculoneuropathy 1 trial · 64 incl. sub-types
4 sub-types
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Demyelinating polyneuropathy 2 trials · 62 incl. sub-types
2 sub-types
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Acute disseminated encephalomyelitis 7 trials · 8 incl. sub-types
3 sub-types
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Central pontine myelinolysis 2 trials
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Balo concentric sclerosis 0 trials
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Schilder disease 0 trials
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Boylan dew greco syndrome 0 trials
Most studied deeper sub-types
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Halted gene therapy study raises questions for AMN patients
Disease control Stopped earlyThis early-stage trial tested a gene therapy called SBT101 for adrenomyeloneuropathy (AMN), a rare nerve disease that causes walking difficulties. Eight adults received either the therapy or a sham procedure. The study was terminated early, so we have limited data on safety and e…
Phase 1/2 • Sponsor: SwanBio Therapeutics, Inc. • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Rare disease study aims to map MLIV's natural course
Knowledge-focused Stopped earlyThis study followed 7 people with Mucolipidosis Type IV (MLIV) to learn how the disease naturally progresses. Researchers used tests like neuropsychological exams, blood and urine tests, and brain MRIs to find better ways to measure the disease. The goal was to improve future cli…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Rare disease mystery: scientists watch AMN progress in hopes of finding a cure
Knowledge-focused Stopped earlyThis study followed 65 adult men with a rare inherited nerve disease called AMN (a form of spastic paraplegia) to understand how their symptoms change over time. Researchers collected data on walking ability and quality of life. The goal was to fill gaps in knowledge about the di…
Sponsor: SwanBio Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC