Demyelinating disease
MONDO:0002562A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.
Also known as: demyelinating disorder
931 clinical trials for this condition and its sub-types, 27 tagged with Demyelinating disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Demyelinating disease
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Demyelinating disease of central nervous system 4 trials · 860 incl. sub-types
2 sub-types
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
- Myelin oligodendrocyte glycoprotein antibody-associated disease 22 trials Sub-types →
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Polyradiculoneuropathy 1 trial · 64 incl. sub-types
4 sub-types
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Demyelinating polyneuropathy 2 trials · 62 incl. sub-types
2 sub-types
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Acute disseminated encephalomyelitis 7 trials · 8 incl. sub-types
3 sub-types
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Central pontine myelinolysis 2 trials
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Balo concentric sclerosis 0 trials
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Schilder disease 0 trials
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Boylan dew greco syndrome 0 trials
Most studied deeper sub-types
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Gene therapy boost for krabbe patients after transplant
Disease control OngoingThis early-phase trial tests a single infusion of a gene therapy called FBX-101 in 9 people with Krabbe disease who have already received a stem cell transplant. The therapy uses a harmless virus to deliver a working copy of the GALC gene, aiming to improve motor function and saf…
Phase 1/2 • Sponsor: Forge Biologics, Inc • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Can an app get teens with MS moving? new study aims to find out
Disease control OngoingThis study tests a smartphone app designed to help teens and young adults with multiple sclerosis become more physically active. The app provides coaching, activity tracking, and educational modules. Researchers will measure changes in physical activity levels, fitness, and quali…
Sponsor: The Hospital for Sick Children • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Could your own belly fat help fight MS?
Disease control PausedThis study tests whether a patient's own fat cells, processed into a special mixture called stromal vascular fraction, can safely improve quality of life and slow nerve damage in multiple sclerosis. About 100 adults with stable MS who have lasting nerve problems will receive an I…
Sponsor: Healeon Medical Inc • Aim: Disease control
Last updated Jun 26, 2026 15:54 UTC
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Can PET scans reveal hidden brain inflammation in MS?
Diagnosis By invitation onlyResearchers at Mayo Clinic are testing whether advanced PET and MRI brain scans can measure inflammation in people with multiple sclerosis and other inflammatory demyelinating diseases. The study includes about 200 participants, both patients and healthy controls. Participants re…
Phase 2 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Sep 19, 2026 00:00 UTC
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Massive italian MS registry aims to unlock secrets of the disease
Knowledge-focused By invitation onlyThis observational study is creating a large database of up to 96,000 people with multiple sclerosis and related conditions in Italy. Researchers will collect information on patient demographics, treatments, and disease progression over time. The goal is to better understand thes…
Sponsor: Fondazione Italiana Sclerosi Multipla • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New ultrasound could better track carpal tunnel recovery
Knowledge-focused By invitation onlyThis study tests a new ultrasound technique called shear wave elastography to measure stiffness in the wrist nerves and tissues of people with carpal tunnel syndrome. Researchers will compare these measurements with standard tests before and after treatment (surgery or steroid in…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC