Demyelinating disease
MONDO:0002562A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.
Also known as: demyelinating disorder
931 clinical trials for this condition and its sub-types, 27 tagged with Demyelinating disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Demyelinating disease
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Demyelinating disease of central nervous system 4 trials · 860 incl. sub-types
2 sub-types
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
- Myelin oligodendrocyte glycoprotein antibody-associated disease 22 trials Sub-types →
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Polyradiculoneuropathy 1 trial · 64 incl. sub-types
4 sub-types
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Demyelinating polyneuropathy 2 trials · 62 incl. sub-types
2 sub-types
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Acute disseminated encephalomyelitis 7 trials · 8 incl. sub-types
3 sub-types
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Central pontine myelinolysis 2 trials
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Balo concentric sclerosis 0 trials
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Schilder disease 0 trials
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Boylan dew greco syndrome 0 trials
Most studied deeper sub-types
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Could an allergy pill help heal the brain in MS? new trial aims to find out
Disease control Not yet recruitingThis study tests whether clemastine fumarate, an over-the-counter allergy medication, can repair damaged nerve insulation (myelin) in people with multiple sclerosis. About 44 adults with relapsing-remitting MS will receive either the drug or a placebo for 3 months, then all will …
Phase 1/2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New study aims to understand physical challenges in kids with nerve diseases
Knowledge-focused Not yet recruitingThis study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…
Sponsor: Istanbul University - Cerrahpasa • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Could a daily walk shield the brain's wiring in aging MS patients?
Knowledge-focused Not yet recruitingThis study investigates whether physical activity and other lifestyle factors are linked to changes in myelin—the protective coating around nerve fibers—in people aged 50 to 70 who have had multiple sclerosis for over a decade. Participants will undergo MRI scans to measure myeli…
Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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New study seeks clues to recovery in rare childhood brain condition
Knowledge-focused Not yet recruitingThis study aims to find what factors predict recovery in children with acute disseminated encephalomyelitis (ADEM), a rare brain condition. Researchers will follow 25 children aged 6 months to 18 years to see how many recover fully and how many have relapses. The study does not t…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC
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Hidden heart risks in kids with brain conditions?
Knowledge-focused Not yet recruitingThis study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:21 UTC