Cystic fibrosis-related liver disease
MONDO:7770005A liver disorder that arises as a consequence of cystic fibrosis. Cystic fibrosis-related liver disease encompasses a spectrum of hepatobiliary abnormalities caused by CFTR dysfunction in cholangiocytes, including focal biliary cirrhosis, multilobular biliary cirrhosis, hepatic steatosis, and cholangiopathy. It is a significant cause of non-pulmonary morbidity and mortality in CF, affecting approximately 5-10% of CF patients.
Also known as: CF liver disease, CF-related liver disease, CFLD
3 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsBroader categories
-
Scientists hunt for genes behind liver disease in cystic fibrosis
Knowledge-focused OngoingThis study looks at genes, other than the CF gene, that might explain why some people with cystic fibrosis develop severe liver disease while others do not. Researchers are analyzing blood samples and medical records from 154 participants with CF who have serious liver problems. …
Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
-
Real world clinical outcomes with novel modulator therapy combinations in people with CF (RECOVER)
OngoingRECOVER is a prospective, multicenter observational study designed to measure the real world clinical effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) triple combination therapy in people with cystic fibrosis initially over a two year period, followed by a five year extens…
Phase 4 • Sponsor: Royal College of Surgeons, Ireland
Last updated Sep 09, 2026 17:00 UTC