Cushing syndrome due to macronodular adrenal hyperplasia
MONDO:0009049A rare adrenal Cushing syndrome characterized by bilateral benign adrenal macronodules (>1 cm) that potentially produce autonomously variable levels of cortisol excess. Although in most cases are ACTH-independent, non-suppressed ACTH levels have been described.
Also known as: ACTH-independent Cushing syndrome, ACTH-independent macronodular adrenal hyperplasia, primary bilateral macronodular adrenal hyperplasia, ACTH-independent macronodular adrenocortical hyperplasia, AIMAH, MMAD, adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, corticotropin-independent macronodular adrenal hyperplasia
12 clinical trials for this condition and its sub-types.
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Broader categories
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New pill targets hormone imbalance from adrenal tumors
Disease control CompletedThis study tested a daily pill called SPI-62 in 30 adults with high cortisol levels caused by a non-cancerous adrenal tumor. The goal was to see if the drug could safely lower blood sugar and improve other health measures. Participants took 2 mg of SPI-62 each day for up to 12 we…
Phase: PHASE2 • Sponsor: Sparrow Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New drug aims to tame cortisol overload from adrenal tumors
Disease control CompletedThis Phase 3 trial tested a drug called relacorilant in 137 people with hypercortisolism caused by adrenal adenomas or hyperplasia. The goal was to see if it could improve blood sugar control and lower high blood pressure. Participants received either relacorilant or a placebo fo…
Phase: PHASE3 • Sponsor: Corcept Therapeutics • Aim: Disease control
Last updated Jun 26, 2026 14:09 UTC
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Researchers measure breathing, strength, and quality of life in hospitalized endocrine patients
Knowledge-focused CompletedThis completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…
Sponsor: Uşak University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC