Clonal hematopoiesis of indeterminate potential
MONDO:0100543A precancerous condition characterized by the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.
29 clinical trials for this condition and its sub-types.
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New hope for heart patients: drugs target hidden inflammation from blood mutations
Disease control CompletedThis study tested two experimental drugs, DFV890 (a daily pill) and MAS825 (a single shot), in 31 adults with coronary heart disease and a blood condition called CHIP. The goal was to see if these drugs could reduce specific markers of inflammation linked to heart risk. The trial…
Phase: PHASE2 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Hidden gene changes may raise heart risk even after quitting smoking
Knowledge-focused CompletedThis completed study looked at 1029 patients who had a heart attack or unstable angina and quit smoking. Researchers checked for certain gene mutations (called CHIP) in their blood. They wanted to see if these mutations are linked to a higher chance of future heart problems, like…
Sponsor: Shenyang Northern Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:27 UTC