Chiari malformation type I
MONDO:0007316Arnold-Chiari malformation type I is a central nervous system malformation characterized by caudal displacement of the cerebellar tonsils exceeding 5mm below the foramen magnum with or without syringomyelia. Symptoms vary in onset and severity and include suboccipital headache, neck pain, vertigo, tinnitus, ocular symptoms (diplopia, blurred vision, photofobia, nystagmus), lower cranial nerve signs, cerebellar ataxia, and spasticity. Some affected individuals can be asymptomatic.
Also known as: Arnold-Chiari malformation type 1, Arnold-Chiari malformation type I, Chiari malformation type 1, Chiari malformation type I, Chiari malformation type 1 with syringomyelia, Cm1, Cm1 with syringomyelia
8 clinical trials for this condition and its sub-types.
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Brain surgery showdown: which chiari fix works best?
Disease control CompletedThis study looked at 250 people with Chiari malformation type I and syringomyelia to compare two surgical approaches: one that opens the covering of the brain and spinal cord, and another that also removes or shrinks the tonsils at the base of the brain. The goal was to see which…
Phase: NA • Sponsor: Xuanwu Hospital, Beijing • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Scientists hunt for genes behind chiari brain malformation
Knowledge-focused CompletedThis study looked at the genetics of Chiari I malformation, a condition where part of the brain pushes into the spinal canal. Researchers analyzed DNA and family histories from 152 participants to find genes that may cause the malformation. The goal was to better understand why i…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Long-Term study tracks spinal cord cyst disease to guide future treatments
Knowledge-focused CompletedThis study followed 180 adults with syringomyelia, a condition where a cyst forms in the spinal cord, for up to 5 years. Researchers tracked symptoms, muscle strength, and MRI scans to learn how the disease progresses and how surgery affects outcomes. The goal was to gather knowl…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Scientists hunt for genes behind chiari malformation
Knowledge-focused CompletedThis completed study looked for genetic causes of Chiari type I malformation, a condition where part of the brain pushes into the spinal canal. Researchers took blood samples from 40 people with the condition and their relatives to analyze their DNA. The goal was to find specific…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC