Cerebral cortical dysplasia
MONDO:0017094Abnormalities in the development of the cerebral cortex. These include malformations arising from abnormal neuronal and glial cell proliferation or apoptosis (Group I); abnormal neuronal migration (Group ii); and abnormal establishment of cortical organization (Group iii). Many inborn metabolic brain disorders affecting cns formation are often associated with cortical malformations. They are common causes of epilepsy and developmental delay.
Also known as: brain cortical dysplasia, cortical dysplasia
8 clinical trials for this condition and its sub-types.
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Glowing dye could help surgeons spot hidden epilepsy lesions
Disease control Not yet recruitingThis study tests whether a fluorescent dye called 5-ALA can help surgeons see and remove abnormal brain tissue in people with drug-resistant epilepsy caused by focal cortical dysplasia (FCD). FCD lesions are often hard to distinguish from healthy brain during surgery, making comp…
Phase: PHASE2 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New pill aims to tame seizures in rare brain disorders
Disease control Not yet recruitingThis early-stage trial tests an oral drug called SVG103 (Paxalisib) in 15 adults with rare brain conditions (FCD-II, TSC, or HME) that cause seizures. The main goal is to check safety and side effects, while also seeing if it reduces seizure frequency. Participants take the drug …
Phase: PHASE1, PHASE2 • Sponsor: Sovargen • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC