Cerebral cavernous malformation
MONDO:0000820A disorder characterized by malformations in the structure of the capillaries in the brain. It is caused by mutations in the CCM2, KRIT1 and PDCD10 genes. The capillaries fill with blood and stretch, thereby creating cavernous spaces. Some patients experience headaches, seizures, or visual and hearing disturbances. Cerebral hemorrhage may also occur.
Also known as: CCM, brain cavernous hemangioma, cerebral cavernous malformation, familial cavernous angioma
3 clinical trials for this condition and its sub-types.
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Broader categories
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Could a new drug tame dangerous brain blood vessel clusters?
Disease control CompletedThis trial tests an experimental drug called REC-994 in adults with symptomatic cerebral cavernous malformation (CCM), a condition where clusters of abnormal blood vessels in the brain can cause bleeding, seizures, and other symptoms. Participants receive either a low or high dos…
Phase 2 • Sponsor: Recursion Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Can a simple blood test predict brain bleed risk in cavernous malformation patients?
Knowledge-focused CompletedCerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain and spine that can bleed, causing strokes, seizures, and headaches. This study follows people with an inherited form of CCM to identify factors—such as genetics, gut microbiome, and blood …
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jul 29, 2026 00:00 UTC