Could a new drug tame dangerous brain blood vessel clusters?
NCT ID NCT05085561
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial tests an experimental drug called REC-994 in adults with symptomatic cerebral cavernous malformation (CCM), a condition where clusters of abnormal blood vessels in the brain can cause bleeding, seizures, and other symptoms. Participants receive either a low or high dose of REC-994 or a placebo for up to a year, with a long-term extension phase. The study measures safety, symptom changes, and bleeding events to see if the drug can help control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- REC-994
- What this could lead to
- If successful, REC-994 could become the first drug treatment to reduce symptoms and bleeding events in people with cerebral cavernous malformation.
- What could go wrong
- This is a small, early-phase trial. The drug may not prove more effective than placebo, and long-term safety is still unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cleveland Clinic Florida
Port Saint Lucie, Florida, 34987, United States
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Columbia University Medical Center
New York, New York, 10027, United States
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Emory
Atlanta, Georgia, 30322, United States
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Lyerly Neurosurgery
Jacksonville, Florida, 32207-8202, United States
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Stanford University
Palo Alto, California, 94304, United States
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The University of Texas Southwestern Medical Center
Dallas, Texas, 75390-8855, United States
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19104, United States
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UCLA
Los Angeles, California, 90095, United States
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University of Florida
Gainesville, Florida, 32608, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15260, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Virginia
Charlottesville, Virginia, 22908, United States
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Valley Hospital
Ridgewood, New Jersey, 07450, United States
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Xenoscience Inc
Phoenix, Arizona, 85004, United States