Central nervous system cancer
MONDO:0002714A malignant neoplasm involving the central nervous system
Also known as: CNS neoplasm, central nervous system tumor, central nervous system tumour, CNS cancer, CNS malignant neoplasms, CNS neoplasms, malignant, cancer of CNS, cancer of central nervous system
4377 clinical trials for this condition and its sub-types, 131 tagged with Central nervous system cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system cancer
-
Malignant glioma 250 trials · 920 incl. sub-types
12 sub-types
- High grade astrocytic tumor 8 trials · 673 incl. sub-types Sub-types →
- Brain glioma 29 trials · 210 incl. sub-types Sub-types →
- Grade III glioma 44 trials · 88 incl. sub-types Sub-types →
- Oligodendroglial tumor 2 trials · 73 incl. sub-types Sub-types →
- Malignant peripheral nerve sheath tumor 36 trials · 38 incl. sub-types Sub-types →
- Pediatric high-grade glioma 14 trials · 16 incl. sub-types Sub-types →
- Spinal cord glioma 3 trials Sub-types →
- Granular cell cancer 1 trial · 2 incl. sub-types Sub-types →
- Malignant perineurioma 1 trial
- Isolated melanotic schwannoma 0 trials
- Neurofibroma of gallbladder 0 trials
- Neurofibroma of the heart 0 trials
-
Brain cancer 682 trials · 902 incl. sub-types
9 sub-types
- Metastatic malignant neoplasm in the brain 267 trials
- Brain glioma 29 trials · 210 incl. sub-types Sub-types →
- Infratentorial cancer 4 trials · 105 incl. sub-types Sub-types →
- Supratentorial cancer 15 trials · 49 incl. sub-types Sub-types →
- Cerebral ventricle cancer 0 trials · 13 incl. sub-types Sub-types →
- Intracranial primitive neuroectodermal tumor 0 trials · 8 incl. sub-types Sub-types →
- Brain germinoma 1 trial · 4 incl. sub-types Sub-types →
- Cancer of cerebellum 1 trial
- Brain sarcoma 0 trials Sub-types →
-
Primary central nervous system lymphoma 92 trials · 103 incl. sub-types
3 sub-types
- Central nervous system non-hodgkin lymphoma 1 trial · 22 incl. sub-types Sub-types →
- Cerebral lymphoma 2 trials
- Spinal cord lymphoma 0 trials
-
Central nervous system sarcoma 2 trials · 74 incl. sub-types
12 sub-types
- Malignant peripheral nerve sheath tumor 36 trials · 38 incl. sub-types Sub-types →
- Atypical teratoid rhabdoid tumor 35 trials · 36 incl. sub-types Sub-types →
- Brain sarcoma 0 trials Sub-types →
- Central nervous system angiosarcoma 0 trials
- Central nervous system extraskeletal osteosarcoma 0 trials
- Central nervous system fibrosarcoma 0 trials
- Central nervous system leiomyosarcoma 0 trials Sub-types →
- Central nervous system rhabdomyosarcoma 0 trials
- Intracranial extraskeletal myxoid chondrosarcoma 0 trials
- Isolated melanotic schwannoma 0 trials
- Meningeal sarcoma 0 trials Sub-types →
- Spinal cord sarcoma 0 trials
-
Spinal cord cancer 21 trials · 57 incl. sub-types
8 sub-types
- Metastatic malignant neoplasm in the spinal cord 38 trials
- Spinal cord glioma 3 trials Sub-types →
- Spinal cord lymphoma 0 trials
- Spinal cord melanoma 0 trials
- Spinal cord neuroblastoma 0 trials
- Spinal cord primitive neuroectodermal tumor 0 trials
- Spinal cord sarcoma 0 trials
- Spinal meninges cancer 0 trials
-
Central nervous system primitive neuroectodermal neoplasm 8 trials · 24 incl. sub-types
8 sub-types
- Intracranial primitive neuroectodermal tumor 0 trials · 8 incl. sub-types Sub-types →
- Childhood central nervous system primitive neuroectodermal neoplasm 6 trials Sub-types →
- Ependymoblastoma 5 trials Sub-types →
- Ganglioneuroma 5 trials Sub-types →
- Central nervous system tumor with bcor internal tandem duplication 1 trial
- Adult central nervous system primitive neuroectodermal neoplasm 0 trials Sub-types →
- Spinal cord neuroblastoma 0 trials
- Spinal cord primitive neuroectodermal tumor 0 trials
-
Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types
4 sub-types
- Esthesioneuroblastoma 9 trials
- Embryonal tumor with multilayered rosettes 8 trials
- Ependymoblastoma 5 trials Sub-types →
- Medulloepithelioma 3 trials
-
Malignant tumor of meninges 0 trials · 14 incl. sub-types
10 sub-types
- Anaplastic meningioma 9 trials
- Malignant leptomeningeal tumor 3 trials · 4 incl. sub-types Sub-types →
- Cerebral meningioma 0 trials · 1 incl. sub-types Sub-types →
- Intraventricular meningioma 0 trials Sub-types →
- Lung meningioma 0 trials
- Meningeal melanomatosis 0 trials
- Meningeal sarcoma 0 trials Sub-types →
- Meninges hemangiopericytoma 0 trials
- Skin meningioma 0 trials Sub-types →
- Spinal meninges cancer 0 trials
-
Malignant adrenal gland pheochromocytoma 11 trials
-
Central nervous system germinoma 2 trials · 4 incl. sub-types
3 sub-types
- Brain germinoma 1 trial · 4 incl. sub-types Sub-types →
- Childhood central nervous system germinoma 1 trial Sub-types →
- Adult central nervous system germinoma 0 trials
-
Central nervous system melanocytic neoplasm 1 trial · 4 incl. sub-types
3 sub-types
- Primary melanoma of the central nervous system 2 trials · 3 incl. sub-types Sub-types →
- Meningeal melanocytoma 1 trial
- Diffuse meningeal melanocytosis 0 trials
-
Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types
1 sub-type
- Pineal region yolk sac tumor 1 trial
-
3 sub-types
- Adult central nervous system choriocarcinoma 0 trials
- Pediatric CNS choriocarcinoma 0 trials
- Pineal region choriocarcinoma 0 trials
-
2 sub-types
-
Malignant carotid body paraganglioma 0 trials
-
3 sub-types
-
2 sub-types
Most studied deeper sub-types
-
New drug combo shows promise for kids with brain cancer
Disease control Stopped earlyThis early-phase trial is testing two drugs, avelumab and lenvatinib, together in children with brain tumors that have not responded to prior treatment. The study has two parts: first, finding a safe dose, and second, seeing if the combination can slow tumor growth. Only 17 child…
Phase 1 • Sponsor: EMD Serono Research & Development Institute, Inc. • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
-
Targeted drug pemigatinib tested in brain tumors with specific genetic markers
Disease control Stopped earlyThis phase 2 trial tested the drug pemigatinib in people with recurrent glioblastoma or other brain tumors that have specific changes in FGFR1-3 genes. Participants took a daily tablet for two weeks followed by one week off. The study aimed to see if the drug could shrink tumors,…
Phase 2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
-
Early trial of experimental cancer drug halted; data still under review
Disease control Stopped earlyThis early-phase study tested a new drug called PF-07284890, alone or with another drug (binimetinib), in 65 people with advanced cancers that have a specific genetic change (BRAF V600 mutation), including cancers that spread to the brain. The trial was terminated early, but rese…
Phase 1 • Sponsor: Pfizer • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
-
Spinal tap could replace brain surgery for young tumor patients
Knowledge-focused Stopped earlyThis study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring…
Sponsor: Pediatric Brain Tumor Consortium • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
-
Scientists examine stored tumor samples to uncover DNA clues in Kids' brain cancers
Knowledge-focused Stopped earlyThis study looked at stored tumor samples from 139 children with brain and central nervous system tumors. Researchers wanted to find DNA changes and biomarkers that could help understand these cancers better. The study was terminated early, so results may be limited.
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC