Castleman disease
MONDO:0015564Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.
Also known as: AFLH, Castleman disease, Castleman's disease, Castleman's tumor, Castleman's tumour, GLNH, angiofollicular ganglionic hyperplasia, angiofollicular lymph hyperplasia
64 clinical trials for this condition and its sub-types, 8 tagged with Castleman disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Castleman disease
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Multicentric Castleman disease 13 trials
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1 sub-type
- Castleman-Kojima disease 0 trials
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Localized Castleman disease 1 trial
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Pediatric Castleman disease 0 trials
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Rapamycin drug tested for rare castleman disease
Disease control OngoingThis phase 2 study tests the drug sirolimus (rapamycin) in 7 people with idiopathic multicentric Castleman disease who have not improved with standard therapy. The goal is to see if sirolimus can improve symptoms like fatigue, fever, and night sweats, and shrink enlarged lymph no…
Phase 2 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Scientists hunt for genetic clues in rare blood disorders
Knowledge-focused PausedThis study looks at the genetic makeup of rare blood diseases like Castleman disease and Langerhans cell histiocytosis. Researchers will analyze blood or tissue samples from 135 participants to find genetic changes that could be targeted by existing or experimental therapies. The…
Sponsor: Case Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC