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Bone giant cell tumor
MONDO:0005674A benign but locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.
Also known as: GCT of bone, Osteoclastoma, benign, benign bone giant cell tumor, benign bone giant cell tumour, giant cell tumor of bone, giant cell tumor of bone (morphologic abnormality), giant cell tumor of bone NOS (morphologic abnormality), giant cell tumor of the bone
2786 clinical trials for this condition and its sub-types, 7 tagged with Bone giant cell tumor itself.
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Sub-types of Bone giant cell tumor
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Giant cell reparative granuloma 1 trial
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Could a common osteoporosis drug stop bone tumors from coming back?
Disease control Recruiting nowThis phase 3 trial tests whether adding zoledronic acid (a bisphosphonate) to bone cement during surgery can lower the chance of a giant cell tumor of bone returning. About 120 people with primary tumors in their arms or legs will be randomly assigned to receive either standard s…
Phase 3 • Sponsor: St. Louis University • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Blood test may spot bone tumor return without scans or needles
Diagnosis Recruiting nowThis study is testing whether a blood test for a substance called TRACP-5b can help doctors diagnose and monitor giant cell tumor of bone, a rare but aggressive tumor that often comes back after treatment. Researchers will take blood samples from 70 patients during routine checku…
Sponsor: St. Anne's University Hospital Brno, Czech Republic • Aim: Diagnosis
Last updated Jun 27, 2026 12:38 UTC
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Glowing dye could help surgeons spot hidden cancer cells during bone tumor surgery
Diagnosis Recruiting nowThis study tests whether a dye called indocyanine green can help surgeons see any leftover tumor tissue during surgery for giant cell tumor of bone. About 40 patients will receive the dye before surgery, and a special camera will highlight tumor areas. The goal is to see if this …
Phase 4 • Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 08:09 UTC
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New app could revolutionize how we measure sarcoma recovery
Knowledge-focused Recruiting nowThis study is testing whether a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out questionnaires and have their phone passively monitor steps, stairs, and other mobility data for up to a year. The goal is to see if this digit…
Sponsor: University of Calgary • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC