Autoimmune disorder of the nervous system
MONDO:0002977A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis.
Also known as: autoimmune disease of nervous system, autoimmune disease, neurologic, autoimmune diseases, nervous system, autoimmune diseases, neurologic, autoimmune disorders of the nervous system, autoimmune disorders, nervous system, autoimmune nervous system diseases, autoimmune nervous system disorder
1101 clinical trials for this condition and its sub-types, 47 tagged with Autoimmune disorder of the nervous system itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Autoimmune disorder of the nervous system
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Autoimmune disorder of central nervous system 2 trials · 881 incl. sub-types
8 sub-types
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Central nervous system lupus 3 trials
- Autoimmune epilepsy 1 trial
- Miller Fisher syndrome 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autoimmune optic neuritis 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Autoimmune disorder of peripheral nervous system 0 trials · 195 incl. sub-types
4 sub-types
- Myasthenia gravis 159 trials · 160 incl. sub-types Sub-types →
- Guillain-Barre syndrome 23 trials · 39 incl. sub-types Sub-types →
- Autoimmune neuropathy 1 trial
- Autoimmune optic neuritis 0 trials
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Pediatric acute-onset neuropsychiatric syndrome 8 trials · 10 incl. sub-types
1 sub-type
- PANDAS 6 trials
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Autoimmune retinopathy 0 trials
Most studied deeper sub-types
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Hope for teens with down syndrome regression disorder: old drugs, new purpose
Disease control CompletedThis Phase 2 trial tests three commonly used drugs—lorazepam, IVIG, and tofacitinib—in 66 people aged 8 to 30 with Down Syndrome Regression Disorder (DSRD). DSRD causes sudden severe symptoms like loss of speech, movement, and daily living skills. The study aims to see if these d…
Phase 2 • Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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New antibody drug aims to block brain attacks in autoimmune encephalitis
Disease control CompletedThis early-stage trial tested a new drug called ART5803 in 64 healthy adults to see if it is safe. ART5803 is a lab-made antibody designed to block harmful immune proteins that attack the brain in autoimmune encephalitis. The study gave single or multiple doses and compared them …
Phase 1 • Sponsor: Arialys Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Robot suit could help MS patients walk again – small trial underway
Symptom relief CompletedThis study explores whether a powered exoskeleton—a wearable robot—can help people with moderate to severe walking problems due to multiple sclerosis (MS) exercise and walk better. Twenty-four participants will either use the exoskeleton or do standard exercises with a fitness in…
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Can we predict who will relapse after brain inflammation?
Knowledge-focused CompletedThis study examines a rare brain disease called anti-LGI1 encephalitis, where the immune system attacks a protein in the brain, causing memory loss, confusion, and seizures. Researchers will review medical records from 112 patients across five hospitals in Eastern China to see ho…
Sponsor: Shen Chun-Hong • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Blood samples shed light on mysterious muscle disease
Knowledge-focused CompletedThis completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Virtual reality could help spot thinking problems in MS patients
Knowledge-focused CompletedThis completed study looked at 75 people with relapsing-remitting multiple sclerosis (RRMS) who were taking the medication Aubagio. The goal was to see if virtual reality tests and real-world tasks could better detect cognitive (thinking) problems in everyday life compared to sta…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Healthy volunteers help test new drug for brain inflammation
Knowledge-focused CompletedThis early-stage study tested a single dose of a new drug called ART5803 in 7 healthy adults to see if it is safe and how it interacts with another medicine (IVIG). The goal was to gather information for future research on autoimmune encephalitis, a condition where the immune sys…
Phase 1 • Sponsor: Arialys Therapeutics • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Life after a rare brain disease: what happens to patients in the long run?
Knowledge-focused CompletedThis study looked at 20 adults who had NMDA receptor encephalitis, a rare brain condition that can cause psychosis, memory loss, and seizures. Researchers used questionnaires to measure thinking skills, mood, fatigue, and quality of life after the acute phase. The goal was to und…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC