APP-related brain and vascular amyloidosis
MONDO:1060190A hereditary amyloidosis characterized by a spectrum of neurodegenerative and neurovascular phenotypes caused by pathogenic variant in the APP gene, resulting in an abnormal clearance of amyloid peptides, either by overproduction and decreased clearance of amyloid peptides, with deposition of amyloid in plaques and blood vessel walls. Affected individuals may present with progressive cognitive decline, cerebral vascular amyloidosis with white matter changes, and stroke with or without hemorrhage.
Also known as: APP-related brain and vascular amyloidosis
18 clinical trials for this condition and its sub-types, 0 tagged with APP-related brain and vascular amyloidosis itself.
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Sub-types of APP-related brain and vascular amyloidosis
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Alzheimer disease type 1 4 trials
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Cerebral amyloid angiopathy, APP-related 0 trials · 1 incl. sub-types
6 sub-types
- ABeta amyloidosis, dutch type 1 trial
- ABeta amyloidosis, Arctic type 0 trials
- ABeta amyloidosis, Iowa type 0 trials
- ABeta amyloidosis, Italian type 0 trials
- ABetaA21G amyloidosis 0 trials
- ABetaL34V amyloidosis 0 trials
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Could flickering lights and tones help fight Alzheimer's? major trial underway
Disease control CompletedThis study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …
Sponsor: Cognito Therapeutics, Inc. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Acupuncture needles vs. sham: does it really help Alzheimer's?
Symptom relief CompletedThis study tested whether adding acupuncture to standard care can slow down memory and thinking problems in people with mild Alzheimer's disease. Researchers compared real acupuncture to a fake (sham) procedure in 160 participants to see if the effects were real or just a placebo…
Sponsor: Shanghai Institute of Acupuncture, Moxibustion and Meridian • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Could changing your gut bacteria protect your memory?
Knowledge-focused CompletedThis study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…
Sponsor: George Washington University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC