Anterior ischemic optic neuropathy
MONDO:0006649Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis). Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disk is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields. The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety withaspirinor corticosteroids has not been helpful.
Also known as: ischaemic optic neuropathy, ischemic optic neuropathy, aion, optic disc infarction leading to vision loss, optic disk infarction leading to vision loss
14 clinical trials for this condition and its sub-types, 9 tagged with Anterior ischemic optic neuropathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Anterior ischemic optic neuropathy
-
Nasal spray could reverse sudden blindness in groundbreaking trial
Disease control Recruiting nowThis study tests a nasal spray called cenegermin to see if it can improve vision in people who recently lost eyesight from a condition called NAION (a stroke in the optic nerve). About 272 adults will receive either the spray or a placebo. The goal is to measure if more people ga…
Phase 3 • Sponsor: Dompé Farmaceutici S.p.A • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
-
Could stem cells restore sight in damaged eyes?
Disease control Recruiting nowThis study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…
Sponsor: MD Stem Cells • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
-
New MRI technique could spot eye strokes faster
Diagnosis Recruiting nowThis study tests whether an extra 8-minute MRI scan can better detect anterior ischemic optic neuropathy (AION), a type of eye stroke. Researchers will enroll 250 adults with suspected AION and compare the new scan to standard MRI. The goal is to see if the new method is more sen…
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC
-
Nose surgery blood pressure: how low is too low for the eyes?
Knowledge-focused Recruiting nowResearchers compare two blood pressure targets during controlled hypotension for nose surgery to see how each affects blood flow in the eye's optic nerve. Sixty adults having elective rhinoplasty receive anesthesia aimed at either a lower or higher mean arterial pressure. The tea…
Sponsor: Hitit University • Aim: Knowledge-focused
Last updated Sep 21, 2026 15:00 UTC
-
New laser device could revolutionize eye disease detection
Knowledge-focused Recruiting nowThis study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…
Sponsor: Randy Kardon • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
-
New imaging study aims to stop blindness from misdiagnosed artery inflammation
Knowledge-focused Recruiting nowThis study looks at two conditions that can cause sudden vision loss: giant cell arteritis (GCA), a blood vessel inflammation that needs urgent treatment, and NAION, a similar condition that does not benefit from that treatment. Researchers will use special PET/MRI scans and eye …
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC