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Annular epidermolytic ichthyosis

MONDO:0011870

Annular epidermolytic ichthyosis (AEI) is a rare clinical variant of epidermolytic ichthyosis (EI) characterized by the presence of a blistering phenotype at birth and the development from early infancy of annular polycyclic erythematous scales on the trunk and extremities.

Also known as: AEI, ichthyosis, annular epidermolytic, Ciehk, epidermolytic ichthyosis, annular, ichthyosis, cyclic, with epidermolytic hyperkeratosis

3 clinical trials for this condition and its sub-types.

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Sub-types

Ichthyosis, annular epidermolytic 1 (0) Ichthyosis, annular epidermolytic, 2 (0)

Broader categories

Disease (680) Hereditary disease (176) Skin disorder (132) Human disease (14) Ichthyosis (12) Hereditary skin disorder (6) Inherited ichthyosis (6) Disease of genetic or genomic mechanism (2) Epidermolytic ichthyosis (1) Keratinization disease (1)
Not yet finished but already full! 1 Completed 1 Terminated 1
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  • New ointment shows promise for rare skin condition

    Disease control Completed

    This Phase 3 study tested an ointment called TMB-001 in 153 people aged 6 and older with X-linked or ARCI ichthyosis, conditions that cause dry, scaly, and cracked skin. Participants applied the ointment or a placebo daily for 12 weeks, with some continuing for maintenance. The g…

    Phase: PHASE3 • Sponsor: LEO Pharma • Aim: Disease control

    Last updated Jun 27, 2026 12:36 UTC

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