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Alport syndrome

MONDO:0018965

A rare renal disease characterized by glomerular nephropathy with hematuria progressing to end-stage renal disease (ESRD), frequently associated with sensorineural deafness, and occasionally with ocular anomalies.

Also known as: hereditary nephritis, Alport deafness-nephropathy, Alport syndrome, Alport's syndrome

40 clinical trials for this condition and its sub-types.

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Sub-types

X-linked Alport syndrome (3) Autosomal recessive Alport syndrome (2) Alport syndrome 3b, autosomal recessive (0) Autosomal dominant Alport syndrome (0) Digenic Alport syndrome (0)

Broader categories

Disease (618) Inflammatory disease (310) Kidney disorder (202) Hereditary disease (172) Urinary system disorder (62) Syndromic disease (24) Hereditary nephritis (17) Nephritis (16) Human disease (14) Disease of genetic or genomic mechanism (2)

Trials to join now! 16 Not yet recruiting 3 Not yet finished but already full! 8 Completed 12 Terminated 1

Experimental kidney drug for alport syndrome falls short in early trial

Disease control Terminated

This phase 2 trial tested a weekly injection of lademirsen in 43 adults with Alport syndrome, a genetic condition that damages kidneys. The goal was to see if the drug could slow the decline in kidney function. The study was terminated early, so the results are limited and it's u…

Phase: PHASE2 • Sponsor: Genzyme, a Sanofi Company • Aim: Disease control

Last updated Jun 26, 2026 16:08 UTC