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This randomized controlled trial investigates the effects of biofeedback-guided training versus conventional therapy on muscle strength and postural alignment in patients with Upper Cross Syndrome. The study includes adults aged 25-45 years meeting diagnostic criteria for UCS, su…

Sponsor: Riphah International University

Last updated Sep 10, 2026 15:00 UTC

Evaluation of semaglutide safety and tolerability in adults with cocaine use disorder with and without HIV

The purpose of this research study is to find out if semaglutide is safe and well tolerated in adults with cocaine use disorder who do and do not have human immunodeficiency virus (HIV). Participants will complete a screening process and if you are able to participate, you will b…

Phase 2 • Sponsor: University of Maryland, Baltimore

Last updated Sep 10, 2026 15:00 UTC

Effect of a combination of myofascial release technique to conventional physiotherapy program on functional outcomes in pediatric cerebral palsy post achilles tendon surgery in the gaza strip

"This study aims to evaluate the effectiveness of adding Myofascial Release (MFR) technique to a conventional physiotherapy program for children with cerebral palsy after Achilles tendon surgery. The primary goal is to determine whether MFR can improve functional outcomes such as…

Sponsor: Ismail K. Al-Qudra

Last updated Sep 10, 2026 15:00 UTC

Real-world investigation of diagnosis, treatment, and survival status of children with ph+ ALL in china

The study aims to conduct a real-world investigation of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in China, assessing their diagnosis, treatment status, survival outcomes, and prognostic factors. The research will involve children diagn…

Sponsor: The Children's Hospital of Zhejiang University School of Medicine

Last updated Sep 10, 2026 15:00 UTC

Predictive value of lung ultrasound combined with serum ANGPL4 levels for NICU admission needs in late preterm and term neonates with respiratory distress in the transion period

The aim of this study is to evaluate the validity of point-of-care lung ultrasound (POC-LUS) and serum ANGPL4 levels for predicting NICU admission needs in late preterm and full-term neonates with respiratory distress shortly after birth in the transition period.

Sponsor: Tanta University

Last updated Sep 10, 2026 15:00 UTC

Relationship between gastrocnemius and soleus muscle thickness assessed by ultrasound and balance and fear of falling in hemiplegic patients

Structural and functional changes occurring in the lower extremity muscles of hemiplegic stroke patients play a decisive role in gait ability, balance impairment, and fall risk. In this context, the relationship between muscle architecture parameters such as the thickness of the …

Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Last updated Sep 10, 2026 15:00 UTC

Structural versus adaptive salivary signatures across Implant-Supported prosthetic configurations: a Cross-Sectional comparison of sIgA, MMP-8, and MMP-9

This observational cross-sectional study compared salivary biomarkers among adults with different types of implant-supported prosthetic rehabilitation and periodontally healthy adults with natural teeth. A total of 107 participants were included in four groups: periodontally heal…

Sponsor: Akdeniz University

Last updated Sep 10, 2026 15:00 UTC

Adaptation and implementation of a behavioral mHealth intervention to reduce anxiety and depression and end the HIV epidemic in the rural south

This study will adapt and assess the preliminary effectiveness of a community health worker-delivered mental health counselling intervention delivered remotely to reduce anxiety and depression among people with HIV in Florida.

Sponsor: University of Florida

Last updated Sep 10, 2026 15:00 UTC

Electrical impedance tomography (EIT) to evaluate the effect of different concentrations of ropivacaine on pulmonary ventilation function during intercostal nerve blockade

This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery. Researchers will use a non-invasive imaging technique called …

Sponsor: Fudan University

Last updated Sep 10, 2026 15:00 UTC

Oxygen therapy during exercise training in inpatient rehabilitation in chronic lung disease- does it matter?

The aim of the current study is the effect of SSOT during a 3-weeks inpatient pulmonary rehabilitation program. Further aim is to analyze exercise endurance, distinguishing between those exercising whilst breathing air at 760m "normoxia", breathing air at approx. 1600m "hypoxia",…

Sponsor: Eastern Switzerland University of Applied Sciences

Last updated Sep 10, 2026 15:00 UTC

A ketamine-assisted group therapy intervention for spanish-speaking adults with depression

This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression

Phase 1/2 • Sponsor: Juliana Zambrano, MD, MPH

Last updated Sep 10, 2026 15:00 UTC

Serial multiomics profiling using serum and cerebrospinal fluid samples following out-of-hospital cardiac arrest: a prospective observational study

The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is: A. The main ques…

Sponsor: Chungnam National University Hospital

Last updated Sep 10, 2026 15:00 UTC

Evaluation of burnout syndrome among healthcare professionals in intensive care units within the EPIC (Enhancing palliative care in ICU) research

One hundred ICU doctors, nurses and psychologists from the 28 units participating in the EPIC stepped-wedge trial (ClinicalTrials.gov NCT06605079) will each complete the same four-part survey twice-once during their unit's usual-care phase and again during the EPIC tele-palliativ…

Sponsor: University of Athens

Last updated Sep 10, 2026 15:00 UTC

Extensive post-discharge counselling and phone-based follow-up intervention to reduce heart failure readmission- a pilot randomized control trial

In Ghana, about 88.3 per cent of cardiac admissions are due to Heart failure, making it the leading cause of admission due to heart conditions. Despite improved knowledge on heart failure and an increasing array of evidence-based guideline treatment options, there is still a sign…

Sponsor: Komfo Anokye Teaching Hospital

Last updated Sep 10, 2026 15:00 UTC

Adapting rehabilitation delivery for maximum impact at Home-2 (ReDI-2)

People who live in rural areas and have hip or knee arthritis can have difficulty receiving physical therapy (PT) close to home. Living with hip or knee arthritis can make doing daily activities and being physically active difficult. This can lead to other health conditions, such…

Sponsor: University of Alberta

Last updated Sep 10, 2026 15:00 UTC

A multicentre, randomised, double-blind, positive-drug-controlled phase III clinical trial on the efficacy and safety of CZ1S peroneal nerve block combined with popliteal artery and posterior capsule gap block for postoperative analgesia in total knee arthroplasty.

This is a multicentre, randomised, double-blind, positive-drug-controlled confirmatory clinical trial designed to evaluate the efficacy and safety of CZ1S injection for femoral nerve block (FNB) combined with the interspace between the popliteal artery and the capsule of the knee…

Phase 3 • Sponsor: Zhejiang Cuize Pharmaceutical Technology Co., Ltd.

Last updated Sep 10, 2026 15:00 UTC

A multicenter phase 1 study to determine the safety and efficacy of multiple doses at defined intervals of rhenium (186Re) obisbemeda (Rhenium-186 NanoLiposome, 186RNL) administered via intraventricular catheter for any primary solid tumor cancer with leptomeningeal metastases

This is an open-label, multicenter, Phase 1 study to determine the safety and efficacy of multiple doses at defined intervals of rhenium (186Re) obisbemeda (rhenium-186 nanoliposome, 186RNL) administered via intraventricular catheter for any primary solid tumor cancer with leptom…

Phase 1/2 • Sponsor: Cerenome

Last updated Sep 10, 2026 15:00 UTC

Digital transformation in the implementation of socially differentiated and Patient-Centered health care after heart transplantation: the mHTX APP program

By invitation only

Current Danish studies emphasize the importance of better integrated and efficient lifelong health care to heart-transplant recipients regardless of socioeconomic position. Our objective is to design and evaluate a new digital patient-centered and socially differentiated program …

Sponsor: University of Aarhus

Last updated Sep 10, 2026 15:00 UTC

Single-Fraction very accelerated partial breast irradiation (sfVAPBI) in Low-Risk invasive or ductal in situ breast carcinoma - phase II multicenter trial