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Structural versus adaptive salivary signatures across Implant-Supported prosthetic configurations: a Cross-Sectional comparison of sIgA, MMP-8, and MMP-9

NCT ID NCT07813845

NEW Sponsor: Akdeniz University Source: ClinicalTrials.gov ↗

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First seen Sep 10, 2026 · Last updated Sep 10, 2026

Summary

This observational cross-sectional study compared salivary biomarkers among adults with different types of implant-supported prosthetic rehabilitation and periodontally healthy adults with natural teeth. A total of 107 participants were included in four groups: periodontally healthy individuals with natural teeth, patients with implant-supported partial fixed prostheses and remaining natural teeth, patients with full-arch fixed implant-supported prostheses, and patients with implant-retained overdentures. The study measured three biomarkers in unstimulated whole saliva: secretory immunoglobulin A (sIgA), matrix metalloproteinase-8 (MMP-8), and matrix metalloproteinase-9 (MMP-9). These biomarkers are related to oral immune responses and tissue remodeling. The main aim was to determine whether salivary biomarker levels differed according to dentition status and type of implant-supported prosthesis. The study also examined relationships between these biomarkers and clinical parameters, including probing depth. No experimental treatment or intervention was assigned by the study protocol.

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Study facts

What this study's own registry entry says, in plain language.

Participants

107 people

The number who actually took part.

Started

Aug 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults attending the Department of Prosthodontics, Faculty of Dentistry, Akdeniz University were recruited and classified according to their existing dentition and prosthetic status. The study population included periodontally healthy fully dentate individuals without implants and patients rehabilitated with implant-supported partial fixed prostheses, full-arch fixed implant-supported prostheses, or implant-retained overdentures. Prosthetic rehabilitation was present before enrollment and was not assigned by the study protocol.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older. * Ability and willingness to provide written informed consent. * For the healthy dentate group: fully dentate individuals without dental implants who were systemically and periodontally healthy, with probing depths of 3 mm or less at all sites and full-mouth bleeding on probing below 10%. * For the implant groups: presence of an implant-supported partial fixed prosthesis, full-arch fixed implant-supported prosthesis, or implant-retained overdenture with osseointegrated implants restored with a definitive prosthesis in function for at least 6 months. Exclusion Criteria: * Antibiotic use within the preceding 6 months. * Periodontal therapy within the preceding 6 months. * Systemic conditions known to affect periodontal or immune status, including diabetes mellitus, cardiovascular disease, rheumatoid arthritis, systemic lupus erythematosus, or inflammatory bowel disease. * Systemic infectious diseases, including tuberculosis, hepatitis, or human immunodeficiency virus infection. * Mucocutaneous diseases affecting the oral mucosa, including lichen planus, pemphigus vulgaris, or chronic ulcerative stomatitis. * Ongoing systemic corticosteroid, immunosuppressant, or biologic therapy. * Pregnancy or lactation.

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Peri-implant diseases

Contacts and locations

Locations

  • Akdeniz University Faculty of Dentistry

    Antalya, Antalya, 07058, Turkey (Türkiye)