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127005 trials found · Page 6338 of 6351
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An Open-Label phase 1 study to assess the safety, tolerability, and pharmacokinetics of a single dose of a new tablet formulation of TRTL-729 in healthy adults
Not yet recruitingThis study assesses the safety, tolerability, and pharmacokinetics (PK) of the tablet formulation of TRTL-729 in healthy adults.
Phase 1 • Sponsor: Tortugas Neuroscience, Inc.
Last updated Sep 09, 2026 16:00 UTC
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Evaluation of the efficacy of topical application of liquid nitrogen and ascorbic acid in treatment of gingival pigmentation
By invitation onlyAim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation. Primary outcome: • Clinical severity and extension of gingival pigmentation. Secondary…
Phase 3 • Sponsor: Al-Azhar University
Last updated Sep 09, 2026 16:00 UTC
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RE-irradiation for isolated FOCal recurrence of prostate cancer with ultrahypofracted SBRT: the RE-FOCUS study - pushing the boundaries of precision and efficacy
Not yet recruitingProstate cancer (PCa) is one of the most frequently diagnosed malignancies in men worldwide, with the highest prevalence observed in developed countries. Patients affected by localized disease can be treated with several local modalities, including radical prostatectomy (RP), ext…
Sponsor: European Institute of Oncology
Last updated Sep 09, 2026 16:00 UTC
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Innovation for Women's health: the integration of artificial intelligence in the diagnostic ultrasound assessment of reproductive medicine
Recruiting nowThe goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired endometrial receptivity in women aged 18-45 years.…
Sponsor: Semmelweis University
Last updated Sep 09, 2026 16:00 UTC
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A phase i, Single-Arm, Open-Label study to evaluate the safety, pharmacokinetics and preliminary efficacy of CHT101 injection in subjects with Relapsed/Refractory T-Cell and B-Cell hematological malignancies
Not yet recruitingPrimary Objective: To evaluate the safety, tolerability, and dose-limiting toxicity of anti-CD70 chimeric antigen receptor allogeneic T-cell injection (CHT101) in the treatment of CD70-positive relapsed/refractory T-cell and B-cell hematological malignancies. Secondary Objective…
Phase 1 • Sponsor: Nanjing Miracle Biotechnology Co., Ltd.
Last updated Sep 09, 2026 16:00 UTC
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Intravenous acetate as an adjunctive treatment for alcohol withdrawal in hospitalized patients
Not yet recruitingAlcohol withdrawal syndrome is a highly morbid condition affecting a substantial percentage of patients hospitalized who have alcohol use disorders, estimated at 5-6% of all hospitalized patients. Standard treatment paradigms for alcohol withdrawal syndrome have common and seriou…
Phase 1/2 • Sponsor: University of Colorado, Denver
Last updated Sep 09, 2026 16:00 UTC
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Implant survival after reconstructive surgical therapy of peri-implantitis-related bone defects with different defect configurations
By invitation onlyTo report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
Sponsor: University of Turin, Italy
Last updated Sep 09, 2026 16:00 UTC
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Comparison of perioperative analgesia nociception index (ANI) between preoperative and postoperative ultrasound-guided transversus abdominis plane Block(TAP block) in laparoscopic cholecystectomy
Not yet recruitingThe goal of this clinical trial is to learn if the timing of ultrasound-guided transversus abdominis plane block (US-TAP block) administration (preoperative vs. postoperative) affects the perioperative analgesia nociception index (ANI) in adult patients undergoing laparoscopic ch…
Sponsor: Pusan National University Yangsan Hospital
Last updated Sep 09, 2026 16:00 UTC
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A randomized controlled trial of Serine/Glycine-Restricted diet combined with chemoradiotherapy and immunotherapy for neoadjuvant treatment of rectal cancer
Not yet recruitingThis is a Phase Ib/II seamless, open-label, randomized controlled trial evaluating the safety and efficacy of a serine/glycine-restricted diet combined with neoadjuvant chemoradiotherapy and immunotherapy in patients with locally advanced rectal cancer (LARC). The study consists…
Phase 1/2 • Sponsor: Xuelei Ma MD
Last updated Sep 09, 2026 16:00 UTC
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International consensus statement on the admission, triage, and discharge criteria for oncological patients in the intensive care unit: protocol for a modified delphi consensus study
Not yet recruitingThis study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it. An ICU is a hospital ward for people who are very sick and need close watching and life sup…
Sponsor: Onco Critical Care Society
Last updated Sep 09, 2026 16:00 UTC
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Efficacy and safety of Low-Dose IL-2 in neuromyelitis optica spectrum disorder: a randomized, Double-Blind, Placebo-Controlled phase II trial
Not yet recruitingInterleukin-2 (IL-2) is an essential cytokine for T-cell proliferation. Low-dose IL-2 has been shown to increase the proportion of regulatory T cells (Tregs), negatively regulate effector T cells such as Th17 and Tfh cells, and improve the peripheral Treg/Th17 balance, thus resto…
Phase 2 • Sponsor: Peking University People's Hospital
Last updated Sep 09, 2026 16:00 UTC
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Community engaged Alliance-Reimagined environments and systems together for outcomes georgia through research and evaluation for sustainability (RESTORES) - georgia CEAL RESTORES
Recruiting nowThe goal of this clinical trial is to determine whether a family-based lifestyle intervention reduces the risk of type 2 diabetes (T2D) among parents and their children. The intervention will also evaluate how well the program supports healthy lifestyle behaviors and family engag…
Sponsor: Morehouse School of Medicine
Last updated Sep 09, 2026 16:00 UTC
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A phase II study of total neoadjuvant mFOLFOX6 plus suvemcitug and enlonstobart with selective omission of pelvic radiotherapy for High-Risk Mid-Rectal locally advanced rectal cancer with MSS status
Not yet recruitingThis is a prospective, multicenter, open-label, single-arm Phase II study designed to evaluate the efficacy and safety of total neoadjuvant mFOLFOX6 combined with suvemcitug and enlonstobart in patients with MRI（Magnetic Resonance Imaging）-defined high-risk, mid-rectal, locally a…
Phase 2 • Sponsor: Fudan University
Last updated Sep 09, 2026 16:00 UTC
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The feasibility of electrical impedance tomography to guide non-invasive respiratory interventions in chronic respiratory disease
By invitation onlyThis study aims to use Electrical Impedance Tomography (EIT) to optimise breathing machines for people with problems with their breathing. This might improve their ability to use their breathing machine. By providing real-time pictures of the lungs, EIT can help clinicians tailor…
Sponsor: Royal Free Hospital NHS Foundation Trust
Last updated Sep 09, 2026 16:00 UTC
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The effect of wet towel application during labor on labor pain, comfort, and anxiety: a randomized controlled study
OngoingThe goal of this clinical trial is to learn whether the wet towel method applied during the first stage of labor can reduce labor pain and anxiety and improve childbirth comfort in first-time mothers. The main questions it aims to answer are: Does the wet towel method reduce lab…
Sponsor: Sakarya University
Last updated Sep 09, 2026 16:00 UTC
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Pedal pump clinical trial on edema V2
Recruiting nowPrevious research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal exercise. However, due to the limitation of human practi…
Sponsor: Hillcrest
Last updated Sep 09, 2026 16:00 UTC
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Smart technology facilitated patient-centered care for patients with pulmonary Thromboembolism：A multicenter, randomized controlled trial
Recruiting nowSmart technologies, such as wearable devices, mobile technologies, and artificial intelligence, are being investigated for use in health management. These technologies have the potential to be applied in disease pre-warning, decision-making support, health education, and healthca…
Sponsor: Navy General Hospital, Beijing
Last updated Sep 09, 2026 16:00 UTC
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Effects of adjunct Omega-3 long-chain polyunsaturated fatty acids in pulmonary tuberculosis patients: an early bactericidal activity and inflammatory activity trial
Recruiting nowThe goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients (aged 18- 45 years) with newly diagnosed, bacteriolog…
Phase 2 • Sponsor: North-West University, South Africa
Last updated Sep 09, 2026 16:00 UTC
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Telemedicine technology supporting the diagnostic process based on automated analysis of laboratory test results with a structured medical history: a prospective, Two-Center, Two-Phase clinical validation study
Not yet recruitingThis study evaluates a certified artificial intelligence (AI) based software system that automatically interprets laboratory test results in combination with a structured, dynamically generated medical history questionnaire. The purpose of the study is to determine how accuratel…
Sponsor: Labplus Sp. z o.o.
Last updated Sep 09, 2026 16:00 UTC
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A multicenter, Dose-Escalation and expansion phase I/IIa clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics, immunogenicity, and preliminary efficacy of SGT003 in patients with advanced solid tumors
Recruiting nowA Phase I/IIa clinical study SGT003 in patients with advanced solid tumors.
Phase 1/2 • Sponsor: Beijing Sungen Biomedical Technology Co., Ltd
Last updated Sep 09, 2026 16:00 UTC