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127005 trials found · Page 6337 of 6351
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Interactions between food processing level, nutrition quality, nutrition security and anxiety in israeli adults: influence on dietary intake
Recruiting nowThe UPGRADE Study will examine how food-processing level and nutritional quality affect energy intake, eating rate, satiety, and glycemic response. In a randomized-order crossover design, each participant will consume three laboratory test meals: low processing/high nutritional q…
Sponsor: Ariel University
Last updated Sep 09, 2026 17:00 UTC
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A prospective randomized controlled phase II trial of tai chi for Cancer-Related fatigue during radiotherapy in patients with head and neck malignancies
Not yet recruitingThis prospective, randomized controlled study will evaluate whether a Tai Chi exercise program can help reduce cancer-related fatigue in patients with head and neck cancer undergoing radiotherapy. A total of 116 participants will be randomly assigned in a 1:1 ratio to either a T…
Sponsor: West China Hospital
Last updated Sep 09, 2026 17:00 UTC
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A monocentre, Single-Arm trial to study the effect of lens inspired by myopia control solutions on the astigmatism of a child
Not yet recruitingThe goal of this clinical trial is to investigate over a one-year period the effect of myopia control spectacle lenses on astigmatism in children aged 6 to 13 years with myopia and astigmatism. The main question it aims to answer is: \- How does the eye respond at each timepoin…
Sponsor: Essilor International
Last updated Sep 09, 2026 17:00 UTC
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Diagnostic delay in pulmonary hypertension: determinants and impact on disease severity at initial presentation
Not yet recruitingPulmonary hypertension (PH) is a progressive cardiopulmonary condition that may remain undiagnosed for a prolonged period because its initial symptoms are often nonspecific. This study aims to assess the relationship between diagnostic delay and disease severity at the time of in…
Sponsor: Assiut University
Last updated Sep 09, 2026 17:00 UTC
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Evaluation of the efficacy of topical application of liquid nitrogen and ascorbic acid in treatment of gingival pigmentation
By invitation onlyAim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation. Primary outcome: • Clinical severity and extension of gingival pigmentation. Secondary…
Phase 3 • Sponsor: Al-Azhar University
Last updated Sep 09, 2026 17:00 UTC
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RE-irradiation for isolated FOCal recurrence of prostate cancer with ultrahypofracted SBRT: the RE-FOCUS study - pushing the boundaries of precision and efficacy
Not yet recruitingProstate cancer (PCa) is one of the most frequently diagnosed malignancies in men worldwide, with the highest prevalence observed in developed countries. Patients affected by localized disease can be treated with several local modalities, including radical prostatectomy (RP), ext…
Sponsor: European Institute of Oncology
Last updated Sep 09, 2026 17:00 UTC
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A randomized, phase 1, double-blind, single and Multiple-Ascending dose and food effect study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of OMS1620 in healthy participants
Not yet recruitingThe goal of this study is to explore the safety, drug concentrations and effects on adrenal gland hormones after a single dose or multiple doses of OMS1620 in healthy participants. In addition, the effect of food on drug concentrations will also be tested.
Phase 1 • Sponsor: OMass Therapeutics Australia Proprietary Ltd
Last updated Sep 09, 2026 17:00 UTC
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Brazilian version of a behavior change intervention to support healthy lifestyle adoption after stroke - iVIDAVC: protocol for a pilot randomized study
Recruiting nowIntroduction: Stroke presents a high global burden, particularly in low- and middle-income countries such as Brazil. Stroke secondary prevention, in which the adoption of healthy lifestyle behaviors is a key component, is an important strategy for reducing the global burden of st…
Sponsor: Federal University of Minas Gerais
Last updated Sep 09, 2026 17:00 UTC
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Development and evaluation of effectiveness of an interactive dysphagia education system for patients with stroke
By invitation onlyThe goal of this clinical trial is to learn if an interactive dysphagia education system can improve swallowing outcomes and quality of life in patients with post-stroke dysphagia. The main questions it aims to answer are: Does the interactive dysphagia education system improve …
Sponsor: Mei-Yu Lin
Last updated Sep 09, 2026 17:00 UTC
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A low-intervention prospective-retrospective study to evaluate the pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor combination in a cystic fibrosis population
Not yet recruitingThe goal of this clinical trial is to support the development of personalized therapy tailored to each patient's individual characteristics. A better understanding of the pharmacokinetic profiles of elexacaftor, tezacaftor, and ivacaftor is essential to support Therapeutic Drug M…
Phase 4 • Sponsor: Istituto Giannina Gaslini
Last updated Sep 09, 2026 17:00 UTC
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A phase i, Single-Arm, Open-Label clinical study to evaluate the safety, pharmacokinetics, and preliminary efficacy of CHT101 injection in subjects with Relapsed/Refractory T-Cell and B-Cell hematological malignancies
Not yet recruitingPrimary Objective: To evaluate the safety, tolerability, and dose-limiting toxicity of CD70-targeted chimeric antigen receptor allogeneic T-cell injection (CHT101) in the treatment of subjects with CD70-positive relapsed/refractory T-cell and B-cell hematological malignancies. P…
Phase 1 • Sponsor: Nanjing Miracle Biotechnology Co., Ltd.
Last updated Sep 09, 2026 17:00 UTC
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LPR-2: a prospective, single-center, non-randomized, interventional study on the effectiveness and safety of combined immunotargeted therapy in patients with metastatic non-small cell cancer with a RET gene translocation
Recruiting nowThis interventional study will evaluate the effectiveness, safety, and tolerability of pembrolizumab in combination with lenvatinib in adults with metastatic non-small cell lung cancer (NSCLC) who have a confirmed RET gene rearrangement and whose disease has progressed after one …
Phase 3 • Sponsor: EuroCityClinic LLC
Last updated Sep 09, 2026 17:00 UTC
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Real-world evaluation of the clinical performance and safety of apneal dx for the screening and aid in the diagnosis of obstructive sleep apnea-hypopnea syndrome in adults: a post-market clinical follow-up study
Not yet recruitingSleep apnea-hypopnea syndrome (SAHS) is a frequent and largely under-diagnosed sleep-related breathing disorder. Adult prevalence is estimated between 9% and 38%. Untreated SAHS increases cardiometabolic and neurocognitive risk. Reference diagnostic methods (in-lab polysomnograph…
Sponsor: Mitral
Last updated Sep 09, 2026 17:00 UTC
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A phase 1, Single-Center, randomized, Double-Blind, Placebo-Controlled study to evaluate the safety, tolerability, and pharmacokinetics of HRS-1597 tablets following Single-Dose administration in healthy participants and Multiple-Dose administration in obese participants, and the effect of food on the pharmacokinetics of HRS-1597 tablets
Not yet recruitingThis is a Phase 1, single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of HRS-1597 tablets following single-dose administration in healthy participants and multiple-dose administration in obese participants,…
Phase 1 • Sponsor: Shandong Suncadia Medicine Co., Ltd.
Last updated Sep 09, 2026 17:00 UTC
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Implant survival after reconstructive surgical therapy of peri-implantitis-related bone defects with different defect configurations
By invitation onlyTo report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
Sponsor: University of Turin, Italy
Last updated Sep 09, 2026 17:00 UTC
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An Open-Label phase 1 study to assess the safety, tolerability, and pharmacokinetics of a single dose of a new tablet formulation of TRTL-729 in healthy adults
Not yet recruitingThis study assesses the safety, tolerability, and pharmacokinetics (PK) of the tablet formulation of TRTL-729 in healthy adults.
Phase 1 • Sponsor: Tortugas Neuroscience, Inc.
Last updated Sep 09, 2026 17:00 UTC
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Systematic oral hygiene intervention for the prevention and control of oral mucositis in children undergoing hematopoietic stem cell transplantation during the perioperative period: a prospective, randomized controlled clinical trial
Not yet recruitingOral mucositis is one of the most common and debilitating complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Severe oral mucositis can lead to pain, nutritional impairment, infection, prolonged hospitalization, and increased healthcare …
Sponsor: Nanfang Hospital, Southern Medical University
Last updated Sep 09, 2026 17:00 UTC
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Cost-Effectiveness and implementation of integrated Diabetes-Oral health care in oman: a health belief Model-Based intervention to enhance clinical, behavioral, and exploratory oral microbiome in health system outcomes in type 2 diabetes
Not yet recruitingType 2 diabetes mellitus (T2DM) and periodontal (gum) disease are closely related conditions that may negatively affect each other. However, oral health is not routinely integrated into diabetes self-management education. This study will evaluate whether a structured diabetes-ora…
Sponsor: Oman Ministry of Health
Last updated Sep 09, 2026 17:00 UTC
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Effects of therapeutic exercise with and without nerve stimulation on dysphonia in post thyroidectomy patients
Not yet recruitingThis clinical trial evaluates rehabilitation strategies for post-thyroidectomy dysphonia. Voice impairment is a frequent complication following thyroid surgery. It often occurs even without direct laryngeal nerve transection. Surgical trauma, tissue edema, and mechanical stretchi…
Sponsor: University of Lahore
Last updated Sep 09, 2026 17:00 UTC
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A randomized, Double-Blind, Placebo-Controlled phase II trial of pBI-4 plasmid administered via intramuscular TriGrid™ electroporation delivery system for treatment of women with HPV16-Positive grade 1 cervical intraepithelial neoplasia or persistent HPV16 infection
Not yet recruitingThe purpose of this study is to evaluate the safety, efficacy, and tolerability of pBI-4, an investigational therapeutic DNA vaccine, in treating adult women with Human Papillomavirus type 16 (HPV16)-positive Grade 1 cervical intraepithelial neoplasia (CIN1) or persistent HPV16 i…
Phase 1/2 • Sponsor: Chang Gung Memorial Hospital
Last updated Sep 09, 2026 17:00 UTC