New surgical wash aims to cut joint infection risk in 7,600 replacement patients
NCT ID NCT05543941
First seen May 29, 2026
Summary
This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to receive one of the two washes before the wound is closed. The main goal is to see how many develop an infection within 90 days after surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU de Quebec-Université Laval
RECRUITINGQuébec, Quebec, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Humber River Health
RECRUITINGToronto, Ontario, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hôpital Maisonneuve-Rosemont
RECRUITINGMontreal, Quebec, Canada
Contact
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jewish General Hospital
RECRUITINGMontreal, Quebec, Canada
Contact
Contact Email: •••••@•••••
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London Health Sciences Center
RECRUITINGLondon, Ontario, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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St. Joseph's Health Centre
RECRUITINGToronto, Ontario, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Ottawa Hospital
RECRUITINGOttawa, Ontario, K1H 8L6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of British Columbia
RECRUITINGVancouver, British Columbia, Canada
Contact Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
XPERIENCE Advanced Surgical Irrigation (a device/solution applied to the wound during surgery)
What this could lead to
If it works, this could provide a better way to prevent serious joint infections after hip or knee replacement surgery.
What could go wrong
This is a large trial, but it compares two existing approaches, so the difference may be small. The solution is new, so unexpected side effects or no benefit are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.