KNEE OSTEOARTHRITIS

This study tests whether injecting stem cells from umbilical cords can help people with knee osteoarthritis. The trial involves 100 adults aged 40-70 who will receive either the stem cells or a placebo. Researchers will measure changes in pain, joint function, and cartilage healt…

This study compares a new surgical irrigation solution (XPERIENCE) to the standard Betadine wash for preventing infections after hip or knee replacement surgery. About 7,600 adults getting a first-time joint replacement will be randomly assigned to one of the two washes. The main…

This study tests whether a single injection of cells from bone marrow or fat tissue can better reduce pain and improve function in people with knee osteoarthritis. 204 adults aged 40-75 with knee OA that hasn't improved with standard care will receive one of the two cell treatmen…

This study tests whether a 6-week walking retraining program using real-time feedback can improve how people walk after ACL reconstruction. The goal is to reduce early signs of knee arthritis (FastOA). Researchers will measure changes in knee forces, cartilage health, and pain ov…

This early-stage study tests a new gene therapy called BBM-A101 for people with moderate knee osteoarthritis. The goal is to see if it is safe and can help reduce pain or improve joint function. About 81 adults with knee arthritis will receive the treatment and be monitored for s…

This study is testing a knee replacement system called Persona Revision in 380 adults who need a second knee replacement surgery. The goal is to see if it improves knee pain, stability, and movement over two years. Researchers will also track any side effects or need for further …

This study tests if doing supervised exercise and learning about your condition for at least 8 weeks before knee replacement surgery leads to better knee function and satisfaction one year later, compared to standard care. About 110 adults with knee osteoarthritis will take part.…

This study looks at two different methods of giving a nerve block (adductor canal block) to control pain after total knee replacement surgery. About 78 adults with knee osteoarthritis will take part. The goal is to see which approach provides better pain relief and helps patients…

This study compares two knee braces for people with knee osteoarthritis. Researchers want to see which brace better reduces pain during walking and improves daily function. About 30 adults aged 40 to 85 with mild-to-moderate knee arthritis will wear a brace for 8 weeks. The goal …

This study tests if adding a sugar solution (dextrose) to nerve-blocking injections around the knee provides better pain relief than using numbing medicine alone. Researchers will give up to three injections to 60 adults with chronic knee osteoarthritis and track their pain level…

This study compares an 8-week yoga program to standard therapeutic exercises in 90 adults aged 45 and older with knee osteoarthritis. Researchers will measure changes in pain, balance, daily function, and quality of life. The goal is to see if yoga offers meaningful benefits for …

This study tests whether a 10-week online program that combines gentle exercise with mindfulness can reduce knee pain and improve daily function in people with knee osteoarthritis. About 66 adults aged 50 and older with persistent knee pain will participate entirely from home via…

This study looks at whether giving the steroid dexamethasone before knee replacement surgery can help with early recovery. Researchers will compare patients who get the drug by mouth or IV to those who don't, measuring pain, mobility, nausea, and need for extra painkillers. The g…

This study tests whether focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relievers an…

This study tests a single injection of a substance made from donated human placental tissue (PTP-001) to see if it improves pain and function in people with knee osteoarthritis. About 260 adults aged 40 to 80 with mild to moderate knee OA will receive either the injection or a pl…

This study compares two types of knee replacement implants designed to better match each patient's natural knee shape and movement. The goal is to see which implant helps people feel more like their knee is their own, with less pain and stiffness. About 120 adults needing a first…

This study tests whether a magnesium supplement called Magnesium-L-Threonate can improve sleep quality and reduce pain in people recovering from total knee or hip replacement surgery. Researchers will enroll 64 adults undergoing surgery at the University of Miami Hospital. Partic…

This study looks at whether a structured physical therapy program can improve how people walk and distribute weight on their feet after total knee replacement surgery. Researchers will measure walking speed, step length, and foot pressure in 30 women aged 40-70 before and after t…

This study tests a gentle hands-on technique called Mobilization with Movement (MWM) for people with knee osteoarthritis. Forty adults with moderate to severe knee pain will receive either MWM or a sham version twice a week for four weeks, along with standard exercise and educati…

This study tests whether releasing tight calf muscles can reduce pain and improve movement in women with knee osteoarthritis. Thirty women aged 45-55 will receive either real or sham calf muscle release three times a week for four weeks. Researchers will measure pain during rest …

This study looks at whether adding foot massage to standard cold therapy can reduce pain, improve satisfaction, and lower painkiller use in people who have had knee replacement surgery. Sixty adults will be randomly assigned to receive either cold therapy alone or cold therapy pl…

This study tests whether a newer anesthetic drug, remimazolam, causes less confusion (delirium) after hip or knee surgery in elderly patients compared to a standard drug, propofol. About 82 older adults having hip or knee replacement will be randomly assigned to receive one of th…

This study tests if a special electromagnetic therapy can reduce pain and improve strength in older adults with knee osteoarthritis. About 64 people aged 60 and older will receive either joint-only or joint-plus-muscle treatment, plus a home exercise program. The goal is to see i…

This study tests whether temporarily restricting blood flow to one thigh (5 minutes on, 5 minutes off, for 50 minutes total) every other day for two weeks can improve walking speed, strength, and pain in people with knee osteoarthritis and low back pain. Researchers will enroll 2…

This study tests if delivering pregabalin (a nerve pain medicine) through the skin using ultrasound, along with calf muscle stretches, can reduce nerve pain and improve walking in people with advanced knee osteoarthritis. About 35 adults aged 40-70 with Grade III knee osteoarthri…

This study tests whether adding a sleep improvement program to personalized exercise coaching helps older adults with knee osteoarthritis feel less pain. Researchers will compare the combined approach to exercise alone in 288 participants. The goal is to see if treating insomnia …

This study compares two treatments for knee osteoarthritis: an ultrasound-guided genicular nerve block (an injection to numb pain nerves) and standard physical therapy. Researchers will measure effects on pain, daily function, and balance in 66 adults aged 40-70 with knee pain fo…

This study tests whether a more concentrated growth factor injection (SRF) works better than standard PRP for knee osteoarthritis. About 90 adults with mild to moderate knee arthritis will receive one of the two injections and be followed for 6 months. The goal is to see if SRF p…

This study tests whether a single injection of hydrolyzed collagen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 204 adults with knee cartilage damage who haven't improved with other treatments will receive either the collagen inject…

This study tests whether a pre-surgery exercise program (prehabilitation) can improve recovery, function, and mood in people waiting for hip or knee replacement. About 44 adults with advanced osteoarthritis will do strength and aerobic exercises before surgery. The goal is to see…

This study tests whether using MRI scans to guide dextrose (sugar water) injections into specific damaged areas of the knee works better than standard injections into the joint space for treating knee osteoarthritis. Sixty adults aged 45 to 80 with moderate knee arthritis will re…

This study looks at whether adding an iPACK nerve block to a standard adductor canal block can lower the body's stress and inflammation after hip replacement surgery. About 60 older adults (ages 65-100) having hip replacement will be randomly assigned to get either the extra bloc…

This study tests a single injection of a new drug (4P004) into the knee joint to see if it reduces pain and improves function in people with knee osteoarthritis and synovitis (inflammation of the joint lining). About 129 adults aged 40 to 80 will receive either the drug or a plac…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

This study tests whether platelet-rich plasma (PRP) injections work better than hyaluronic acid (HA) injections for people with advanced knee osteoarthritis (grades III or IV). About 150 adults with knee pain will receive either PRP or HA injections, and their pain and function w…

This study is testing whether injecting a mix of hyaluronic acid and fibrinogen into the knee joint can reduce pain and improve movement in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection and be followed for several months. The goal is to…

This study looks at two types of injections for knee osteoarthritis: one with dextrose (a type of sugar) and one with a local anesthetic (numbing medicine). Researchers will follow 86 adults for six months to see which injection better reduces pain and improves daily function. Th…

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The injection contains substances that may reduce friction in the knee joint. About 286 adults aged 40 to 79 with knee pain will receive either ALLOHEAL or a similar approved treatment. The…

This study tests whether a mobile app can help people recovering from hip, knee, or spine surgery do simple exercises while still in bed. About 100 adults will use the app during their hospital stay. Researchers will measure how well patients move and how satisfied they are with …

This study tests a procedure called Genicular Artery Embolization (GAE) for people with mild-to-moderate knee osteoarthritis. The goal is to see if injecting tiny microspheres into knee arteries can safely reduce pain and improve function. 15 participants will be followed for 3 y…

This study looks at whether adding low-level laser therapy to a home exercise program can reduce pain and improve knee function in people with knee osteoarthritis. It also checks if the laser can help reverse muscle loss around the thigh. About 62 adults over age 50 will take par…

This study looks at whether doing physical therapy exercises through a video game helps people with knee osteoarthritis move better and stay motivated. Sixty adults with knee OA will do 10 weeks of exercises, some using a special game with sensors and others doing standard therap…

This study tests whether an artificial intelligence (AI)-assisted exercise app can reduce pain and improve knee function better than a standard paper exercise program. About 84 adults with knee osteoarthritis will use either the AI app or a paper plan for 6 weeks. The goal is to …

This study compares two methods of knee replacement surgery: traditional mechanical alignment (MA) and newer kinematic alignment (KA) that mimics the knee's natural position. About 95 adults with knee arthritis will be randomly assigned to one method and followed for 6 weeks. The…

This study tests whether a hyaluronic acid injection into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also check if the injection lowers certain inflammation markers in blood and joint fluid. 50 adults aged 45-75 with moderat…

This study looks at how a person's background and their clinic visit experience affect how well a topical pain gel (diclofenac) works for knee osteoarthritis. Researchers will track 220 adults aged 50+ with knee pain over 8 weeks. Participants will use the gel and answer question…

This study tests two ways to guide a treatment called cooled radiofrequency ablation for knee osteoarthritis pain. The treatment uses heat to calm nerves around the knee. Researchers want to see if using ultrasound is better than the standard X-ray method for targeting the right …

This study tests two different ways to numb the knee after total knee replacement surgery in 80 adults aged 65 and older. Both methods use a main nerve block to keep leg strength while adding a second block to target back-of-knee pain. The goal is to see which combination provide…

This study looks at whether a 3-week thermal spa treatment at Enghien-les-Bains can reduce pain and improve daily function in people aged 50-80 with knee osteoarthritis. Participants receive the spa treatment plus usual care, and their results are compared to a similar group that…

This study tests whether adding shock wave therapy to knee strengthening exercises reduces pain and improves function more than exercises alone in people with knee osteoarthritis. Forty adults with moderate knee pain will participate during a hospital stay. The goal is to find a …

This study tests whether custom-made, 3D-printed knee replacements work better than standard ones for people with knee arthritis. Twenty adults aged 40 to 70 will get either a custom or standard implant. Researchers will check how well the implant fits, how much pain patients fee…

This early-phase study tests whether a noninvasive brain stimulation technique called rTMS can reduce pain and depression in people with knee osteoarthritis. Thirty volunteers aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also …

This study tests whether giving duloxetine, an antidepressant that also eases pain, before and after knee replacement surgery can lower the need for opioid painkillers. About 150 adults with knee osteoarthritis will take part. The goal is to improve pain control and reduce opioid…

This study tests whether a gentle massage technique (Bowen technique) combined with backward walking can improve hamstring flexibility, reduce pain, and boost mobility in people with knee osteoarthritis. Researchers will enroll 36 adults aged 40-60 with mild to moderate knee arth…

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach provides better pain control, helps patients move sooner, and improves overall …

This study tests whether adding dexamethasone or dexmedetomidine to standard numbing medicine can reduce the need for strong painkillers after knee replacement. About 96 older adults will be randomly assigned to one of three groups to compare pain relief and side effects. The goa…

This study tests a procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with knee osteoarthritis. Researchers will compare knee fluid samples and MRI scans before and after the procedure to see if changes in inflammatio…

This study looks at whether taking collagen peptide supplements before total knee replacement surgery can improve tissue healing, strength, and recovery. About 44 adults aged 50-75 with knee osteoarthritis will take collagen or a placebo for 8 weeks before surgery. Researchers wi…

This study looks at two different ways to align a new knee joint during robotic-assisted knee replacement surgery. About 240 people with knee osteoarthritis will be randomly assigned to one of two alignment methods. The goal is to see which approach helps patients feel more natur…

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis. Researchers want to see how the surgery affects the kneecap joint and arthritis progression over the long term. Participants are under 65 and had the surgery at least 5…

This study is testing whether artificial intelligence (AI) can use information collected before knee replacement surgery—like genetics, physical function, and behavior—to predict how well each person will recover. Researchers will follow 197 adults with severe knee osteoarthritis…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants answer surveys at 6 weeks, 3 months, 6 months, and 1 year after surgery. The goal is to better understand the recovery process for golfers, not…

This study aims to improve total knee replacement surgery for people with severe knee arthritis and a bow-legged (varus) deformity. Researchers will use advanced CT scans to compare the angle of the affected leg with the healthy leg, helping surgeons decide how much to correct th…

This study is creating a registry of up to 100 people with knee osteoarthritis to see how well a procedure called genicular artery embolization (GAE) works over time. GAE blocks certain blood vessels to reduce pain. The goal is to measure pain changes using a standard questionnai…

This study tests a new tool to help surgeons balance knee ligaments during total knee replacement. It involves 40 adults over 40 who need knee surgery. The goal is to see if the tool makes ligament balancing more consistent and accurate, without causing harm.

This study uses a special type of PET/MRI scan to locate painful inflammation in the knee joint of people with patellofemoral osteoarthritis. Researchers will compare scans taken before and after exercise in 50 adults (both with knee pain and healthy volunteers). The goal is to b…

This study aims to create and test an Italian version of a standard knee questionnaire, the New Knee Society Knee Scoring System. Researchers will translate the English survey into Italian, check its accuracy, and then ask about 300 Italian patients with knee osteoarthritis to fi…

This study looks at whether a person's neighborhood resources affect how well they recover from knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce…

This study is a large registry that will follow 10,000 people with knee osteoarthritis to see how well different pain treatments work. Treatments include injections, nerve blocks, and surgery. The goal is to collect real-world data on pain relief, function, and side effects to he…

This study aims to identify substances in blood and joint fluid that can predict how knee osteoarthritis will progress and whether treatments like steroid injections will work. Researchers will follow 200 people with knee osteoarthritis for up to 10 years, collecting samples and …

This study aims to find out if brain scans and pain sensitivity tests can predict which medicine works best for knee osteoarthritis pain. 180 adults with knee pain will be randomly assigned to take duloxetine, celecoxib, or a placebo for about 20 weeks. The goal is to match peopl…

This study looks at how the angle of your knee joint (seen on an X-ray) relates to pain, daily function, quality of life, and fear of movement in people with knee osteoarthritis. Researchers will measure these factors in 100 adults using questionnaires and X-ray readings. The goa…

This study looks at how the shape and alignment of the kneecap joint relate to knee pain, including runner's knee and osteoarthritis. Researchers will use special CT scans taken while standing to get a more natural view of the joint. The goal is to find links that could help doct…

This study looks at the best ways to start a group physical therapy program for veterans with knee osteoarthritis at 20 VA medical centers. It does not test whether the therapy works, but rather how to get clinics to adopt it. About 20 sites will participate, and each will offer …

This study compares two types of anesthesia—general (you are fully asleep) and spinal (you are awake but numb from the waist down)—for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications to see whi…

This study follows 150 people aged 18 to 70 who had knee realignment surgery (osteotomy) for arthritis caused by a crooked leg. Researchers want to see how well the knee functions years later and whether this surgery can help patients avoid or postpone a total knee replacement. T…

This study is testing a smartphone app that tracks movement, symptoms, and function in 1,250 people with knee or hip arthritis or joint replacement. The goal is to create a score that helps doctors predict which patients will be satisfied after surgery. Participants use the app t…

This study is testing whether special insoles that measure how you walk, combined with artificial intelligence, can predict how well you'll recover after knee replacement surgery. Researchers will follow 200 adults with knee osteoarthritis who are scheduled for surgery. The goal …

This study is testing whether an app called Genus can help people with knee osteoarthritis learn more about their condition and feel more confident in making treatment decisions. About 204 adults over 50 who are waiting to see a knee specialist will either use the app for 8 weeks…

This study uses special wearable sensors to measure how well people with severe knee osteoarthritis can move their knee before and after getting a total knee replacement. Researchers will track 20 adults over age 60 to find simple movement patterns that could help doctors better …