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New drug studied to reverse blood thinners during emergency bleeding

NCT ID NCT05454787

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025

Summary

This study tracks the safety and effectiveness of Ondexxya, a drug that reverses the effects of certain blood thinners (apixaban, rivaroxaban, or edoxaban) during life-threatening or unstoppable bleeding. Researchers will monitor 300 patients for side effects and how well the drug works in real-world use. The goal is to better understand the drug's risks and benefits in emergency situations.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Site

    WITHDRAWN

    Aichi, Japan

  • Research Site

    RECRUITING

    Aichi, Japan

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    Akita, Japan

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    Aomori, Japan

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    WITHDRAWN

    Chiba, Japan

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    ACTIVE_NOT_RECRUITING

    Chiba, Japan

  • Research Site

    ACTIVE_NOT_RECRUITING

    Ehime, Japan

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    WITHDRAWN

    Ehime, Japan

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    Fukui, Japan

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    ACTIVE_NOT_RECRUITING

    Fukui, Japan

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    WITHDRAWN

    Fukuoka, Japan

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    ACTIVE_NOT_RECRUITING

    Fukuoka, Japan

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    Fukushima, Japan

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    Gifu, Japan

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    ACTIVE_NOT_RECRUITING

    Gifu, Japan

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    WITHDRAWN

    Gunma, Japan

  • Research Site

    ACTIVE_NOT_RECRUITING

    Gunma, Japan

  • Research Site

    RECRUITING

    Gunma, Japan

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    WITHDRAWN

    Hiroshima, Japan

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    WITHDRAWN

    Hokkaido, Japan

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    ACTIVE_NOT_RECRUITING

    Hokkaido, Japan

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    Hyōgo, Japan

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    Ibaraki, Japan

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    Ishikawa, Japan

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    Kagawa, Japan

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    Kagoshima, Japan

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    Kanagawa, Japan

  • Research Site

    WITHDRAWN

    Kochi, Japan

  • Research Site

    WITHDRAWN

    Kumamoto, Japan

  • Research Site

    ACTIVE_NOT_RECRUITING

    Kumamoto, Japan

  • Research Site

    WITHDRAWN

    Kyoto, Japan

  • Research Site

    WITHDRAWN

    Mie, Japan

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    ACTIVE_NOT_RECRUITING

    Mie, Japan

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    Miyagi, Japan

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    Miyazaki, Japan

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    Nagano, Japan

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    ACTIVE_NOT_RECRUITING

    Nagano, Japan

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    WITHDRAWN

    Nagasaki, Japan

  • Research Site

    RECRUITING

    Nagasaki, Japan

  • Research Site

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    Nara, Japan

  • Research Site

    WITHDRAWN

    Niigata, Japan

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    ACTIVE_NOT_RECRUITING

    Niigata, Japan

  • Research Site

    WITHDRAWN

    Numakunai, Japan

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    Okayama, Japan

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    Okinawa, Japan

  • Research Site

    WITHDRAWN

    Osaka, Japan

  • Research Site

    ACTIVE_NOT_RECRUITING

    Osaka, Japan

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    Saga, Japan

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    Saitama, Japan

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    Shiga, Japan

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    Shimane, Japan

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    Shizuoka, Japan

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    Tochigi, Japan

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    ACTIVE_NOT_RECRUITING

    Tochigi, Japan

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    WITHDRAWN

    Tokushima, Japan

  • Research Site

    WITHDRAWN

    Tokyo, Japan

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    ACTIVE_NOT_RECRUITING

    Tokyo, Japan

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    ACTIVE_NOT_RECRUITING

    Tottori, Japan

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    WITHDRAWN

    Toyama, Japan

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    WITHDRAWN

    Wakayama, Japan

  • Research Site

    ACTIVE_NOT_RECRUITING

    Wakayama, Japan

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    WITHDRAWN

    Yamagata, Japan

  • Research Site

    ACTIVE_NOT_RECRUITING

    Yamagata, Japan

  • Research Site

    WITHDRAWN

    Yamaguchi, Japan

  • Research Site

    WITHDRAWN

    Yamanashi, Japan

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FACTOR XA INHIBITOR LIFE THREATENING BLEEDING