Astrazeneca

This study tests a new drug called surovatamig in 240 adults with B-cell non-Hodgkin lymphoma (follicular or large B-cell) that has returned or not responded after at least two prior treatments. The drug is given alone, and researchers will measure how many people's tumors shrink…

This study follows 200 people in South Korea who are taking Koselugo (selumetinib) for neurofibromatosis type 1 with plexiform neurofibromas. Researchers will track side effects and how well the drug works in everyday medical practice. The goal is to confirm the drug's safety and…

This study tests a new treatment called AZD0120, which uses a patient's own immune cells engineered to attack two targets (BCMA and CD19) on myeloma cells. It is for people whose multiple myeloma has returned or stopped responding to prior treatments. The study compares AZD0120 t…

This study looks at how well benralizumab works for people with severe eosinophilic asthma in real-life situations. About 300 adults in Germany will take the drug as prescribed by their doctor. Researchers will track asthma control, lung function, and medication use over a year t…

This study monitors 300 patients who receive Ondexxya to reverse the effects of certain blood thinners during a life-threatening or unstoppable bleeding event. Researchers will track side effects and how well the drug works in everyday hospital use. The goal is to better understa…

This study tests an experimental drug called anifrolumab, given as a shot under the skin, for adults with polymyositis or dermatomyositis—rare diseases that cause muscle weakness and skin rashes. About 240 people will receive either the drug or a placebo, added to their usual tre…

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed prostate cancer. The goal is to see how these drugs affect cancer cells and check for side effects. About 120 men with localized, higher-ris…

This early-stage study tests the safety of a new drug called AZD1613 in 40 adults with autosomal dominant polycystic kidney disease (ADPKD). Participants receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to see if …

This study tests a new drug called AZD6750, which helps the immune system fight cancer. It is for adults with advanced solid tumors like melanoma, lung cancer, or breast cancer that have not responded to other treatments. The study will check safety, find the best dose, and see i…

This study tests an experimental drug called AZD0292 in people aged 12 and older who have bronchiectasis and a long-term lung infection with Pseudomonas bacteria. The goal is to see if the drug can reduce the number of serious lung flare-ups (exacerbations) compared to a placebo.…

This study is for people with limited-stage small cell lung cancer whose cancer has not gotten worse after chemotherapy and radiation. The goal is to see if the drug durvalumab, given as a follow-up treatment, is safe and helps keep the cancer from coming back. About 70 adults in…

This study tests a new drug called volrustomig in people with advanced head and neck cancer that hasn't spread. After completing standard chemoradiation, participants either receive volrustomig or are simply observed. The goal is to see if the drug can delay the cancer from growi…

This study tests a new drug called AZD9793 for people with advanced liver cancer that has spread. The drug is an antibody that helps the body's immune cells attack cancer cells. The study will check if the drug is safe and if it can shrink tumors. About 304 adults with a specific…

This study tests a new drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers that have spread. The goal is to see if the drug shrinks tumors and how safe it is. About 257 adults with good o…

This study follows 200 adults with systemic lupus erythematosus (SLE) who are starting anifrolumab as part of their usual treatment. Researchers will measure disease activity, skin symptoms, fatigue, and quality of life over time to see how well the drug works in real-world setti…

This study is checking how safe and tolerable the drug Breztri Aerosphere is for people with moderate to severe COPD. It involves 150 adults in India who have had recent COPD flare-ups. The goal is to monitor side effects, not to cure the disease.

This study tests a new treatment called AZD0120 for adults with severe lupus that hasn't responded to other therapies. AZD0120 uses a patient's own immune cells, modified to target and destroy faulty cells driving the disease. The trial will check if the therapy is safe and can r…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps, with or without asthma. Researchers will track changes in nasal blockage and polyp size over a year. About 110 participants will be observed in real-world clinics, not in a lab.

This study follows 125 adults with lupus who are starting a new injectable medication called anifrolumab. Researchers want to see how many patients achieve remission (low disease activity) after 24 months of treatment in routine care. The goal is to understand if this drug helps …

This early-stage study tests a new medicine called AZD4063 in 31 adults with a specific genetic form of dilated cardiomyopathy (PLN R14del). The main goal is to check if the drug is safe and how it moves through the body. Participants must be 18-80 years old, have a weakened hear…

This study looks at whether training doctors to quickly start and adjust a specific set of heart failure medications during a hospital stay leads to better long-term treatment and health outcomes. About 438 adults with heart failure and reduced pumping ability will be followed af…

This study tests a new drug called AZD7760 to see if it is safe and how it works in the body. First, healthy volunteers will receive a single dose. Then, people with end-stage kidney disease who get dialysis through a neck or chest catheter will receive one or two doses. The goal…

This study tests a new drug called AZD0516, alone or with other cancer medicines, in people with metastatic prostate cancer (cancer that has spread). The main goals are to check safety, find the best dose, and see if it can lower PSA levels, a marker of prostate cancer. About 177…

This study tests whether a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) can prevent serious heart and lung events better than a dual inhaler in people with COPD who are at high risk. About 5,000 adults aged 40-80 with COPD and a history of smoking will …

This study is testing a new drug called AZD2962, which blocks a protein called IRAK4, to see if it is safe and can help people with certain blood cancers (like myelodysplastic syndromes or chronic myelomonocytic leukemia) that have not improved with standard treatments. About 72 …

This study tests a new drug called AZD8205, alone or with other cancer drugs, for people with advanced solid tumors like breast, ovarian, or lung cancer. About 460 adults whose cancer has spread or returned after standard treatment will take part. The goal is to find safe doses a…

This early-stage study tests an experimental drug called rilvegostomig given as a shot under the skin (subcutaneous) instead of through an IV. The goal is to find a dose that works safely in adults with advanced solid tumors who have already tried standard treatments. About 40 pa…

This study tests new immune-boosting drugs, alone or with other cancer treatments, in people with advanced liver or bile duct cancer. The goal is to see if these drugs can shrink tumors or slow the disease. About 294 adults whose cancer has spread or cannot be removed by surgery …

This study tests a new medicine called tozorakimab for people hospitalized with a serious viral lung infection who need extra oxygen. The goal is to see if adding this drug to standard care can prevent death or the need for a breathing machine or life support. About 2,870 adults …

This study tests whether people with severe asthma who are taking the drug tezepelumab can safely cut back on their other daily asthma medications without losing control of their symptoms. About 400 participants aged 12 to 80 will try to reduce or stop certain inhalers and pills …

This study tests a new treatment called AZD0120 for people with multiple myeloma that has come back or not responded to other therapies. The treatment uses a patient's own immune cells, modified to target two proteins (CD19 and BCMA) on myeloma cells. About 182 adults will take p…

This early-stage study tests a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. The main goal is to check if the drug is safe and how the body processes it. Participants receive either one or two doses under the skin and are monitored for 6 mont…

This study tests an experimental tablet called AZD6793 in about 987 adults with moderate to very severe COPD. Participants must have had at least two moderate or one severe flare-up in the past year and be on standard triple therapy. The goal is to see if the drug reduces the num…

This early-stage study tests a new medicine called surovatamig in 48 adults with rheumatoid arthritis or lupus. The main goal is to check safety and how the body handles the drug. Participants receive increasing doses to find the best and safest level.

This early-phase study tests a new drug called AZD4956, alone or with other cancer medicines, in 180 adults with advanced or spreading solid tumors that have specific DNA repair defects. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. …

This study tests whether a new drug, rilvegostomig, combined with standard treatments (bevacizumab with or without tremelimumab) helps people with advanced liver cancer live longer. About 1220 adults whose cancer cannot be removed or treated with local therapies will take part. T…

This study tests a new drug called AZD4360 in adults with advanced stomach, bile duct, or pancreatic cancers that have not responded to other treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 117 people will take part…

This study tests a new drug called Dato-DXd, given alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if it can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prostate, ovarian…

This study tests a new medicine called AZD2389 in adults with fatty liver disease and advanced liver scarring. The goal is to see if the drug is safe and can improve liver health. About 104 people will take either the drug or a placebo for 24 weeks. The main focus is on changes i…

This study tests a new drug, rilvegostomig, against the standard immunotherapy pembrolizumab for people with advanced non-small cell lung cancer that has high levels of PD-L1. About 830 participants will receive one of the two treatments as their first therapy. The goal is to see…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if the drug can delay cancer growth. About 100 adults whose cancer has spread and cannot …

This study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the risk of heart failure and heart-related death more than dapagliflozin alone. It involves about 11,300 adults aged 40 and older with type 2 diabetes, heart disease, high blood pressure, and…

This study tests whether adding the drug saruparib to standard radiation and hormone therapy can delay the spread of cancer in men with high-risk prostate cancer that has a BRCA gene mutation. About 700 men will receive either saruparib or a placebo alongside their usual treatmen…

This study tests whether adding the experimental drug sonesitatug vedotin (with or without rilvegostomig) to standard chemotherapy can help people with a specific type of advanced stomach, gastroesophageal junction, or esophageal cancer. About 2,130 adults whose tumors have a pro…

This study tests whether older or frail adults newly diagnosed with large B-cell lymphoma can get just 2 rounds of chemo (R-mini-CHOP) followed by a new drug called AZD0486, instead of the usual 6 rounds of chemo. The goal is to see if the shorter chemo-plus-new-drug approach wor…

This study tests an experimental drug called AZD1163 in 320 adults with moderate-to-severe rheumatoid arthritis (RA) who haven't responded well to standard treatments. The goal is to see if the drug can reduce joint swelling and pain better than a placebo over 12 weeks. Participa…

This study tests new drug combinations in 120 people with metastatic colorectal cancer that has spread. The goal is to see if these combinations can control the cancer longer and improve survival. Participants must have measurable tumors and not have had prior treatment for advan…

This study tests a new combination of two drugs (saruparib and camizestrant) against standard treatments for advanced breast cancer that is hormone receptor-positive and HER2-negative. It is for people with inherited mutations in BRCA1, BRCA2, or PALB2 genes. The goal is to see i…

This study tests a drug called acalabrutinib in 60 adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The goal is to see if acalabrutinib causes fewer heart-related side effects compared to other standard treatments. Participants will b…

This study is testing an experimental drug called AZD9574, given alone or with other cancer treatments, in people with advanced solid tumors that have grown despite prior therapy. The main goals are to check the drug's safety, find the right dose, and see if it can help control t…

This study tests a new experimental drug called AZD8421, given alone or with other targeted cancer drugs, in women with advanced ER+ HER2- breast cancer or high-grade serous ovarian cancer that has spread. The main goals are to check the drug's safety and find the right dose. Abo…

This study tests whether adding benralizumab (a monthly injection) to standard medium-dose inhalers can reduce asthma attacks better than switching to high-dose inhalers. About 400 people aged 12–75 with eosinophilic asthma that is not well controlled will take part. The goal is …

This study tests whether a combination of two drugs (zibotentan and dapagliflozin) works better than dapagliflozin alone in reducing protein in the urine of adults with chronic kidney disease. High protein levels indicate kidney damage. About 224 participants will take either the…

This study tests a drug called osimertinib for people with a specific type of stage III lung cancer that cannot be removed by surgery. Participants take the drug before and after radiation therapy. The goal is to see if this approach helps control the cancer longer. The study is …

This study is testing whether adding an extra medication called glycopyrronium to standard asthma treatment can improve lung function in children aged 4 to under 12. About 69 children with asthma will receive two different doses of the drug or a placebo, in addition to their usua…

This study tests a new drug called Dato-DXd, given alone or with osimertinib, against standard chemotherapy for people with a specific type of advanced lung cancer (EGFR-mutated non-small cell lung cancer) that has worsened after osimertinib treatment. About 744 participants will…

This study is checking how safe and effective Fasenra is for children aged 6 to 14 with severe asthma that doesn't get better with standard treatments. About 40 kids will receive the injection and be monitored for side effects and improvements in lung function and asthma symptoms…

This study tests a drug called tezepelumab in 180 adults with chronic sinusitis and nasal polyps who are eligible for surgery. The goal is to see if the drug reduces nasal congestion and other sinus symptoms over 24 weeks. Participants receive the drug every 4 weeks, and research…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancers that have not responded to standard therapy. The main goals are to check safety and find the best dose. About 506 participant…

This study tests whether a new drug called rilvegostomig, when added to standard chemotherapy, helps people with advanced biliary tract cancer live longer compared to another drug, durvalumab, plus the same chemo. About 1100 adults with inoperable or spread bile duct or gallbladd…

This study is checking the safety of a drug called trastuzumab deruxtecan in 100 Indian adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. Participants have already tried another anti-HER2 treatment. The main goal is to track any sid…

This study tests a new drug called AZD0901, alone or with other cancer treatments, in people with advanced solid tumors that have a specific protein called CLDN18.2. The goal is to see if the drug is safe and can shrink tumors. About 224 adults with stomach, pancreatic, or bile d…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 participants will receive either the drug or a placebo daily through an IV while in the hospital. The main goal is to see if the drug helps improve kidney functio…

This study tests an investigational drug called anifrolumab in children aged 5 to 17 with moderate to severe systemic lupus erythematosus (lupus). The goal is to see if adding anifrolumab to standard treatments can better control disease activity. About 100 children will particip…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works and what side effects…

This study is testing a new drug called AZD1390 combined with radiation therapy for people with glioblastoma (a fast-growing brain cancer) or brain tumors that have spread from other cancers. The main goals are to check the drug's safety, find the best dose, and see how the body …

This study looks at how well ravulizumab works for people with generalized myasthenia gravis (gMG), a condition that causes muscle weakness. Researchers will track changes in daily activities and symptoms over time. About 50 adults in Poland who have not tried similar drugs befor…

This early-phase study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific genetic change (TP53 R175H mutation) and a certain immune marker (HLA-A*02:01). NT-175 uses a patient's own immune cells, whi…

This study tests new combinations of drugs in people with advanced non-small cell lung cancer that has spread. About 278 adults will receive different treatment mixes to see if they shrink tumors and are safe. The goal is to find better ways to control the disease, not to cure it…

This study tests an investigational drug called tezepelumab in children aged 5 to 11 with severe asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce serious asthma attacks and improve lung function. About 231 children will receive e…

This early-stage study tests a new drug called AZD0486 in people with B-cell non-Hodgkin lymphoma that has come back or not responded to other treatments. The drug is a special antibody that helps the immune system attack cancer cells. The main goals are to check safety and find …

This study tests a new drug, AZD0486, in teens and adults whose B-cell acute lymphoblastic leukemia (B-ALL) has come back or not responded to at least two prior treatments. The goal is to see if the drug is safe and can shrink or eliminate cancer cells. Because participants may n…

This study looks at whether the drug anifrolumab can help people with lupus reach a state of low disease activity while taking a low dose of steroids (5 mg or less per day). About 218 adults in Italy will be observed for 52 weeks. The goal is to see if this treatment approach can…

This study tests whether adding dapagliflozin to baxdrostat reduces protein leakage in urine (a sign of kidney damage) more than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take the combination or baxdrostat plus a placebo for sever…

This study looks at whether the drug durvalumab, given after standard chemoradiation, can help control limited-stage small-cell lung cancer. About 200 adults in China will receive durvalumab and be followed to see how long the cancer stays away. The goal is to improve disease con…

This study tests new combinations of cancer drugs in people with advanced or metastatic non-small cell lung cancer. The goal is to see if these combinations are safe and can shrink tumors. About 152 participants will receive either a novel drug paired with another novel drug or w…

This study tests a drug called surovatamig in people with a type of leukemia (CLL/SLL) that has a higher risk of coming back. After finishing their first round of treatment, some participants will receive surovatamig injections, while others will just be watched. The goal is to s…

This study tests an experimental drug called AZD6621 for men with metastatic prostate cancer that has spread. The drug is designed to help the body's immune cells attack cancer cells. The trial has two parts: first, finding the safest dose, then testing that dose in a larger grou…

This study tests several new drug combinations given before and after surgery for people with early-stage non-small cell lung cancer. The goal is to see if these combos can shrink or eliminate tumors and prevent the cancer from coming back. About 630 participants will receive one…

This study looks at the long-term safety of a drug called tozorakimab in people with COPD who have had flare-ups in the past. It is for people who have already taken part in earlier studies of this drug. The goal is to monitor side effects and see how well the drug is tolerated o…

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific protein (HER2). About 600 adults wi…

This study tests a new drug called rilvegostomig combined with chemotherapy and trastuzumab deruxtecan (T-DXd) against the current standard treatment for HER2-positive stomach cancer that has spread. About 840 adults with previously untreated advanced disease and a PD-L1 score of…

This study will follow 1,000 people aged 12 and older with severe eosinophilic asthma in China who are prescribed benralizumab. Researchers will track how well the drug controls asthma symptoms and improves daily life over a year. The goal is to see how benralizumab works in real…

This study tests new drug combinations given before and after surgery for people with stomach, gastroesophageal junction, or esophageal cancer that can be removed. About 100 adults who have not had prior treatment will receive the study drugs to see if they are safe and help shri…

This early-stage study is testing whether a targeted cancer drug (trastuzumab deruxtecan) combined with immunotherapy and sometimes chemotherapy is safe for people with advanced HER2-positive non-small cell lung cancer. About 304 participants will receive different drug combinati…

This study tests an experimental drug called AZD2373 in 96 adults with a genetic form of kidney disease caused by APOL1 gene variants. Participants will receive either the drug or a placebo to see if it reduces protein leakage into urine, a sign of kidney damage. The goal is to f…

This study tests a new drug, AZD3632, taken as a pill for people with advanced blood cancers like leukemia and myelodysplastic syndromes. The main goal is to check the drug's safety and find the best dose. About 84 adults with specific genetic changes will take part in this early…

This study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow kidney disease and prevent heart-related death in 5000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or dapagliflozin alone…

This study tests whether a triple-combination inhaler (budesonide/glycopyrronium/formoterol) can improve heart and lung function in people with COPD and hyperinflation (overinflated lungs). About 56 participants will receive either the active inhaler or a placebo, then switch aft…

This study looks at how well the drug T-DXd works for adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good alternatives. About 100 people will take T-DXd as part of their regular care, and researchers will track tumor shrinkage …

This study tests several new drug combinations in people with advanced stomach cancer that cannot be removed by surgery or has spread. The goal is to see if these combinations can shrink tumors or stop the cancer from growing. About 163 adults will take part, and the study is cur…

This study tests an investigational drug called tezepelumab in adults aged 40 to 80 with moderate to very severe COPD. The goal is to see if it can reduce the number of moderate or severe flare-ups (exacerbations) compared to a placebo. Participants must have had at least two mod…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before bladder removal surgery is safe and effective. About 150 adults with muscle-invasive bladder cancer will receive the drug combination, then surgery. The goal is to improve treatment …

This study tests a new drug called AZD4512, alone or with other cancer medicines, in people whose B-cell Non-Hodgkin lymphoma has come back or stopped responding to treatment. The main goals are to check the drug's safety and find the best dose. About 91 adults will take part in …

This study tracks 150 women with advanced or recurrent endometrial cancer who receive a standard chemotherapy plus the immunotherapy drug durvalumab, followed by maintenance therapy with durvalumab alone or combined with olaparib. The goal is to see how well this treatment works …

This study tests whether adding an experimental drug (Dato-DXd) to a standard targeted therapy (osimertinib) helps people with a specific type of advanced lung cancer live longer without the disease getting worse. About 582 adults with EGFR-mutated non-small cell lung cancer that…

This study tests a new drug called AZD0486, alone or with other cancer drugs, in people with B-cell blood cancers like certain lymphomas and leukemias. The goal is to see if it is safe and helps shrink or control the cancer. About 408 adults will take part in this early-phase tri…

This early-stage trial tests a new treatment called AZD0120 for adults with multiple sclerosis (MS) that has not responded to other therapies. AZD0120 uses a patient's own immune cells, modified to target and potentially calm the immune attack on the nervous system. The main goal…

This study tests two experimental drugs, AZD9550 and AZD6234, for weight loss in people who are overweight or obese, with or without type 2 diabetes. The main goal is to check safety and how the body handles different doses. About 160 adults aged 18 to 75 will take part, receivin…

This study tests an experimental drug called AZD5863 in people with advanced stomach, esophageal, or pancreatic cancers that have not responded to other treatments. The drug is designed to help the body's immune cells attack cancer cells that have a specific marker (CLDN18.2). Th…

This study tests a new drug, datopotamab deruxtecan (Dato-DXd), against a standard chemotherapy (docetaxel) in 400 adults with advanced or metastatic non-squamous non-small cell lung cancer that has a specific protein (TROP2) and no treatable gene mutations. The goal is to see if…

This early-stage study is testing a new way to give the cancer drug durvalumab: as a shot under the skin instead of through an IV. The goal is to find a dose that works just as well as the IV version. About 40 adults with various solid tumors will take part to check safety and ho…

This study is tracking 200 adults with advanced liver cancer who are starting a new two-drug treatment (tremelimumab plus durvalumab). Researchers want to see how long it takes for liver function to worsen, how patients feel, and how safe the treatment is. Participants must have …

This study tests whether adding the experimental drug volrustomig to standard chemotherapy helps people with advanced pleural mesothelioma live longer. About 825 adults whose cancer cannot be removed by surgery will receive either the new combination or one of two standard treatm…

This study compares a new drug, puxitatug samrotecan, to standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new drug…

This study tests whether adding the experimental drug capivasertib to standard hormone therapy and CDK4/6 inhibitors can help people with a common type of advanced breast cancer (HR+/HER2-). About 895 adults whose cancer has spread or cannot be removed will be randomly assigned t…

This study looks at whether benralizumab, a drug for severe eosinophilic asthma, can help patients achieve clinical remission—meaning fewer symptoms and less need for steroids. Researchers will follow 335 adults in Italy for up to 24 months to see how many reach partial or comple…

This study tests an experimental drug called AZD3470 in people with certain blood cancers like lymphoma. The drug is taken as a pill, either alone or with other cancer treatments. The main goals are to check safety and find the best dose. About 161 adults and teens will take part…

This study tests an oral drug called AZD0780 to see if it can lower the risk of major heart problems like heart attacks, strokes, and urgent artery procedures. About 15,100 adults with existing heart disease or at high risk will receive either the drug or a placebo. The goal is t…

This study tests a new drug called volrustomig combined with other cancer medicines in people with advanced non-small cell lung cancer. The goal is to see if the combination is safe and can shrink tumors. About 180 adults will take part, and the study is currently recruiting.

This study tests a new daily pill, camizestrant, against standard hormone therapies (like tamoxifen) to see if it better prevents breast cancer from returning in people with ER+/HER2- early breast cancer who have a moderate-to-high risk of recurrence. About 5,500 participants who…

This study tests a drug called trastuzumab deruxtecan (T-DXd), alone or with other treatments, in people with advanced HER2-positive stomach cancer. The goal is to see if the combination is safe and can shrink tumors. About 450 adults with advanced disease that cannot be removed …

This study tests a drug called benralizumab in children aged 6 to 17 with two rare diseases that cause too many eosinophils (a type of white blood cell). The goal is to see if the drug is safe and can help control the disease, possibly reducing the need for steroids. About 14 chi…

This study tests whether a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler for teens aged 12 to 18 with asthma. About 440 participants will use the inhaler only when needed for 52 weeks. The goal is to see if the combo reduces the number …

This study tests a drug called sodium zirconium cyclosilicate (SZC) to safely lower high potassium levels in children under 18. About 140 kids will take the medicine for up to 3 days to correct potassium levels, then continue for 28 days to maintain normal levels, with an option …

This study tests a new drug, AZD0305, alone or with other cancer drugs, in people with multiple myeloma. The goal is to check safety, side effects, and how well it works. About 226 adults with multiple myeloma will take part in this early-phase trial.

This study tests a new daily pill, camizestrant, against standard hormone therapies to see if it better prevents breast cancer from returning in people with ER+/HER2- early breast cancer who have already completed initial treatments. About 4,300 participants at intermediate or hi…

This early-phase study tests a new drug that delivers radiation directly to cancer cells. It is for adults with advanced solid tumors (like lung, colon, or head and neck cancer) that have not responded to other treatments. The main goals are to check safety, find the right dose, …

This study tests whether a new combination pill (balcinrenone/dapagliflozin) works better than dapagliflozin alone at preventing heart failure events and heart-related death. About 4,800 adults with heart failure and moderate-to-severe kidney problems will take one of the two tre…

This early-phase study tests a new drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head/neck, or colorectal cancer that has spread). The main goals are to check safety, find the right dose, and see if it shrinks tumors. Abou…

This study tests a new drug called baxdrostat in about 250 adults with primary aldosteronism, a condition where the body makes too much of a hormone that raises blood pressure. Participants will take either the drug or a placebo daily for several weeks. The goal is to see if baxd…

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig) works better than standard chemotherapy for people with advanced bile duct cancer that has a specific protein called HER2. About 620 adults with untreated, advanced bile duct cancer will t…

This early-phase trial tests a new treatment called AZD0120 for adults with multiple myeloma, a type of blood cancer. The therapy uses a patient's own immune cells, modified to attack two cancer targets (BCMA and CD19). The main goals are to check safety and find the right dose, …

This study tests a new drug, acalabrutinib, combined with standard chemotherapy (R-CHOP) for people with untreated mantle cell lymphoma who cannot have a stem cell transplant. Participants will receive the combo for 6 cycles, then continue acalabrutinib alone plus maintenance rit…

This study tests a medicine called anifrolumab for people with lupus who have not taken strong immune-suppressing drugs before. The goal is to see if the drug can help patients reach remission and reduce or stop their steroid use. About 245 adults will receive weekly injections f…

This study is for people with a certain type of lung cancer (EGFR-mutant NSCLC) that has spread to other parts of the body after they finished a targeted therapy called osimertinib. The goal is to see if adding chemotherapy to osimertinib can help control the cancer for longer. A…

This study tests whether a new drug combination (datopotamab deruxtecan plus rilvegostomig) or rilvegostomig alone works better than the current standard treatment (pembrolizumab) for people with advanced non-squamous lung cancer that has high PD-L1 levels. About 675 participants…

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, in Chinese adults aged 18-55 who are overweight or obese. The goal is to see if they are safe and help with weight loss. Participants will receive injections and be monitored for side effects and wei…

This study tests a new treatment called AZD0754, which uses a patient's own immune cells (CAR T-cells) to target and attack prostate cancer that has spread. About 60 adults with metastatic prostate cancer will receive this therapy to see if it is safe and can shrink tumors or low…

This study tests a new drug called [225Ac]-AZD2284 for men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The main goal is to check the drug's safety and find the best dose. About 136 participants will receive the drug, and researchers wi…

This study is checking the safety and effectiveness of two drugs, Imjudo and Imfinzi, for people with liver cancer (hepatocellular carcinoma) in Korea. About 246 patients who are already eligible for these drugs under Korean guidelines will take part. The goal is to see how well …

This study tests a new drug called AZD9750, alone or with another drug (saruparib), in people whose prostate cancer has spread to other parts of the body and is no longer controlled by standard treatments. The main goals are to check the drug's safety, find the best dose, and see…

This early-phase study tests a new drug called AZD3470 in people with advanced solid tumors that lack a gene called MTAP. The drug is designed to block a protein these cancer cells need to grow. The study will check safety, find the best dose, and see if the drug shrinks tumors w…

This study tests a new drug, AZD2265, which delivers targeted radiation to prostate cancer cells. It is for people with a specific type of advanced prostate cancer that has stopped responding to hormone therapy. The trial compares the new drug to standard treatments to see if it …

This study follows 1,400 adults with moderate to severe COPD who are starting a triple-combination inhaler (Breztri/Trixeo). Researchers want to see how symptoms and quality of life change over 12 months in routine clinics across Latin America, Asia, and the Middle East & Africa.…

This study tests whether a new drug called AZD0486 combined with rituximab works better than standard chemotherapy plus rituximab for people with untreated follicular lymphoma. About 1,018 adults will take part. The goal is to see if the new combination can control the disease lo…

This study tests a new drug, AZD5335, against current standard treatments for women with a type of ovarian cancer that no longer responds to platinum-based chemotherapy. About 1,100 women with high or low levels of a protein called FRα will be randomly assigned to receive AZD5335…

This study tests a new drug called AZD7798 in 30 adults with active Crohn's disease who have an ileostomy. The goal is to see if the drug is safe and helps repair the gut lining compared to a placebo. Participants will be randomly assigned to receive either the drug or a placebo,…

This study tests whether a new drug, datopotamab deruxtecan (Dato-DXd), given alone or with another drug (durvalumab), works better than standard chemotherapy for people with a type of advanced breast cancer called triple-negative breast cancer (TNBC) that has a specific marker (…

This study is a post-marketing requirement from Korean health authorities to monitor the safety and effectiveness of Danicopan when used alongside standard C5 inhibitors (eculizumab or ravulizumab) for Paroxysmal Nocturnal Hemoglobinuria (PNH). It will enroll 8 patients in routin…

This study tests two experimental drugs, camizestrant and atirmociclib, taken together by people with a specific type of advanced breast cancer (ER-positive, HER2-negative) that has worsened after previous treatment. The main goal is to check the safety of the combination and see…

This study tests an experimental drug called AZD4512 in people with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to treatment. The trial has two parts: first, finding a safe dose, then checking how well it works. About 83 participants aged 12 an…

This study tests whether adding a second immunotherapy drug (domvanalimab) to the standard drug durvalumab can better control stage III lung cancer that hasn't grown after initial chemo-radiation. About 860 adults will receive either the combo or durvalumab alone. The goal is to …

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it. About 104 participants will receive either the drug or a placebo, and the study includes peopl…

This study tests a new drug, surovatamig, in 43 adults with a kidney disease called primary membranous nephropathy. The goal is to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Participants receive the drug as a shot under the skin, and res…

This study tests an investigational drug called tozorakimab in about 540 adults aged 18-75 whose asthma is not well controlled despite using medium-to-high dose inhaled steroids. Participants receive either tozorakimab or a placebo as a shot under the skin. The main goal is to se…

This study tests an experimental drug called AZD8359 in adults with metastatic prostate cancer that has spread and is no longer responding to standard treatments. The drug is designed to help the body's immune cells attack cancer cells. The trial has two parts: first, finding the…

This study compares a new immunotherapy drug, rilvegostomig, against the standard drug pembrolizumab, both given with chemotherapy, as a first treatment for people with advanced non-squamous non-small cell lung cancer that has spread and shows a protein called PD-L1. About 878 pa…

This study tests a new drug called rilvegostomig combined with chemotherapy as a first treatment for people with advanced squamous non-small cell lung cancer that has spread. About 880 participants will be randomly assigned to receive either rilvegostomig or the standard drug pem…

This study tests whether adding a new drug called AZD0780 to a standard statin (rosuvastatin) can lower bad cholesterol more than the statin alone. About 76 adults in Russia with high cholesterol will take either AZD0780 or a placebo pill for 12 weeks. The goal is to see if the c…

This study tests an experimental drug called AZD5492 in people with B-cell blood cancers (like lymphoma or leukemia) that have come back or not responded to at least two prior treatments. The drug works by helping the body's immune T-cells find and attack cancer cells. The main g…

This early-stage study tests a new treatment using a patient's own immune cells, modified in a lab to recognize and attack cancer cells with a specific KRAS mutation (G12D). It is for adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not respond…

This early-stage trial tests a new treatment called AZD0120, which uses a patient's own immune cells modified to target and calm overactive immune responses. It is for adults with systemic sclerosis, inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. The main go…

This study tests a new drug called volrustomig in 800 women with high-risk locally advanced cervical cancer who finished standard chemoradiation without the cancer getting worse. The goal is to see if volrustomig can delay the cancer from coming back or improve survival compared …

This study tests an experimental drug called tezepelumab in 990 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups (exacerbations) compared to a placebo over 76 weeks. Participants must be 40-80 years old, have had at lea…

This study looks at how well Airsupra works compared to albuterol for preventing serious asthma attacks in everyday life. Researchers will study about 4,000 people with asthma who use rescue inhalers. The goal is to see which medicine helps people have fewer severe asthma episode…

This study tests a drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce asthma attacks and improve daily symptoms. Participants will receive injections an…

This study tests a new inhaler (PT027) against a standard one (PT007) for Chinese adults with asthma. About 790 people who have had at least one severe asthma attack in the past year will use the inhaler as needed. The goal is to see if PT027 can delay or reduce severe asthma att…

This study tests a combination of two drugs, acalabrutinib and rituximab, in patients aged 80 and older or those 65-79 who are too frail for standard chemotherapy. The goal is to see if this treatment is safe and effective for controlling diffuse large B-cell lymphoma. About 80 p…

This early-stage study tests a new imaging drug called [111In]-FPI-2107 in 12 Chinese adults with a specific type of lung cancer (EGFR mutation-positive NSCLC). The goal is to see if the drug is safe and how it spreads in the body, not to treat the cancer. Participants receive th…

This study is testing a lung cancer screening program for smokers aged 45 to 74. It uses low-dose CT scans and metabolomics to find lung nodules early. The goal is to see how well the program works in a public health setting and to help smokers quit.

This study looks at whether two easy breathing tests (oscillometry and FeNO) done at a primary care clinic can correctly diagnose asthma and COPD, compared to the standard specialist evaluation. About 600 adults with symptoms like wheezing or shortness of breath will take these t…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that thickens the heart muscle. Doctors will receive special training on how to use standard tests like echocardiograms and nuclear scans to diagno…

This study tests a new drug called AZD5148 to see if it can prevent C. difficile infections from returning in adults aged 18 and older. About 230 people who have had a recent C. diff infection will receive either the drug or a placebo. The goal is to find a safe way to stop repea…

This study is checking how safe the drug palivizumab is for preventing severe RSV in infants and children under 24 months who are at high risk. About 138 participants will receive a monthly injection for up to 5 months. The goal is to track any side effects and ensure the medicin…

This study analyzes data from about 2000 people with moderate to severe COPD who started using a triple-combination inhaler (BGF) in routine care. Researchers will compare patients' self-reported breathing and quality-of-life scores at 1, 3, and 12 months after starting treatment…

This study aims to find out how many people with heart disease also have COPD, a serious lung condition. Researchers will track 3,000 adults aged 40 and older who have coronary heart disease, atrial fibrillation, or chronic heart failure. Participants will undergo lung function t…

This study follows 850 Chinese adults with COPD or early signs of COPD for one year. Researchers will collect medical history, lung function tests, blood samples, and CT scans to identify different types of the disease and find patterns that could lead to more personalized treatm…

This study is looking at how common high potassium levels (hyperkalemia) are in Brazilian patients with heart failure, chronic kidney disease, diabetes, or high blood pressure. Researchers will use medical records from over 6,000 people to understand risk factors and how doctors …

This study looks back at medical records of 350 people with chronic lymphocytic leukemia (CLL) who received the drug acalabrutinib through a UK early access program. Researchers want to see how long patients go without their cancer getting worse and how long they live. No new tre…

This study looks at how a new medicine called elecoglipron changes the way the body processes two common cholesterol-lowering drugs, atorvastatin and rosuvastatin. About 40 healthy adults will take the drugs in a fixed order to measure drug levels in the blood. The goal is to und…

This study follows 300 men with metastatic castration-resistant prostate cancer who are taking olaparib as part of their normal care. Researchers want to see how long patients stay on the drug, how well it controls the cancer, and what side effects occur. The goal is to learn how…

This study is observing 355 adults with asthma in China to learn more about their symptoms, treatments, and biological markers. The goal is to find different types of asthma that may need different treatments, helping doctors personalize care in the future. Participants will have…

This early-stage study is testing whether a single dose of an experimental drug called AZD2389 can reach its target in the liver of people with advanced liver scarring (fibrosis or cirrhosis). Researchers will use a special PET scan to measure how much of the drug binds to a prot…

This study tracks 240 pregnant women with lupus who have taken the drug anifrolumab. Researchers want to see if the drug increases the risk of birth defects or other pregnancy problems. The goal is to gather safety information, not to test a new treatment.

This study looks at how a common antifungal drug, itraconazole, changes the way the body processes a cancer drug called AZ14170132. It involves 24 adults with ovarian, primary peritoneal, or fallopian tube cancer that has come back after platinum chemotherapy. The goal is to meas…

This study follows about 300 people with non-small cell lung cancer who are already taking approved AstraZeneca drugs. Researchers will track how long the drugs keep the cancer from growing or coming back. No new treatments are tested—just real-world data collected from routine c…

This study looks at tumor samples from 2,100 Chinese patients with lung, gynecologic, bile duct, or bladder cancers. Researchers want to see if different HER2 tests give the same results. The study does not provide treatment, but aims to improve how doctors diagnose HER2-positive…

This study watches over 3,000 adults with moderate-to-severe lupus to see if the drug anifrolumab increases the risk of serious infections or cancer compared to standard treatments. No new medicine is given—researchers simply analyze health records from people already prescribed …

This study follows 250 men with metastatic castration-resistant prostate cancer who are already taking the drugs olaparib and abiraterone. Researchers will observe how long patients stay on treatment and what happens next. No new treatments are given—the goal is to learn from rea…

This study looks at how many smokers aged 40 and older who visit heart clinics also have undiagnosed COPD, a serious lung disease. Researchers will use breathing tests to check lung function in 1,000 participants across multiple countries. The goal is to understand how often COPD…

This study is testing an artificial intelligence (AI) tool that collects family cancer history through WhatsApp to predict a woman's genetic risk for breast cancer. Researchers will compare the AI's predictions with standard genetic tests in 800 women already identified as high-r…

This study will collect information from about 500 adults in Moscow who have moderate to very severe COPD and have had frequent flare-ups. Researchers will look at their medical history, current treatments, and overall health to better understand the disease and how it is managed…

This early-stage study in 21 healthy adults with overweight or obesity compares how quickly and how much of an experimental drug called AZD6234 gets into the blood after injection under the skin. Researchers will test different versions of the drug to see which one works best. Th…

This study is gathering information from 750 women with advanced ovarian cancer in Germany to see how well current treatments work in everyday medical practice. Researchers will track patients' health, quality of life, and experiences during and after their first round of chemoth…

This study will analyze health records from 15,000 adults with high blood pressure in Brazil's public primary care system. Researchers want to see how often patients with uncontrolled blood pressure get their treatment adjusted within 3 months. The goal is to understand current t…

This study is observing 100 Polish adults with systemic lupus erythematosus (SLE) who are receiving anifrolumab as part of their routine care. Researchers will track changes in disease activity and other health measures over time. The goal is to see how well the drug works in eve…

This study observes about 500 adults in Spain with a specific type of lung cancer (EGFR-mutated NSCLC) who are taking the drug osimertinib. Researchers will collect data from medical records to see how long patients live, how well the drug controls the cancer, and how it affects …

This study looks at how the liver processes two experimental drugs, AZD9550 and AZD6234, in people with different levels of liver function. About 28 adults with either normal liver function or moderate-to-severe liver impairment will receive a single dose of each drug. The goal i…

This study looks back at the medical records of 250 adults in Brazil with advanced non-squamous non-small cell lung cancer. Researchers want to see what treatments patients received after platinum-based chemotherapy failed, and how they fared. No new treatments are given—this is …

This study observes 126 adults with HER2-negative early breast cancer who are prescribed olaparib by their doctor. Researchers will track how many patients complete the full 12-month treatment and look at genetic mutations like BRCA. The goal is to understand real-world treatment…

This study follows 800 adults with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer who are receiving the drug trastuzumab deruxtecan as part of their routine care in Germany. Researchers will track how long patients stay on the treatment before switching and how …

This early-stage study is testing a new drug, AZD1613, in healthy volunteers to see if it is safe and how the body processes it. About 136 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to gather safety and…

This study is checking if people with type 2 diabetes who take the drug exenatide have a higher chance of getting pancreatic cancer compared to those taking other diabetes medicines. Researchers will look at health records from over 24,000 adults across seven European countries. …

This study will follow about 1,850 people with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers will collect data on symptoms, treatments, and outcomes over time to better understand the disease and how current treatments work in everyday practice. …

This study is a disease registry that will collect information from 200 people in Egypt who have neurofibromatosis type 1 (NF1), a genetic condition that causes tumors to grow on nerves. The goal is to understand how the disease progresses over time, what treatments patients rece…

This study is observing 400 men in Russia with aggressive, high-volume metastatic hormone-sensitive prostate cancer. Researchers will track which treatments doctors choose and test blood samples for certain gene mutations. The goal is to understand current care patterns, not to t…

This study is gathering information from 200 adults in Russia who have neurofibromatosis type 1 (NF1) and related tumors called plexiform neurofibromas. Researchers will look at patients' medical records and interview them to learn about their age, symptoms, and overall health. T…

This study will look back at the medical records of 3000 people in China diagnosed with stage I to III non-small cell lung cancer. The goal is to see what treatments doctors actually use and how patients do over time. No new treatments are given—researchers are just gathering inf…

This study looks at how three experimental weight loss drugs (AZD6234, AZD9550, and their combination) change the way birth control pills work in healthy women who are overweight or have obesity. About 50 participants will take the drugs and then a single dose of birth control to…

This study follows 693 adults with severe or very severe COPD in Brazil to see how often they are hospitalized, have flare-ups, or die. Researchers will also check vaccination rates and cancer cases. The goal is to gather real-world data on this group, since national information …

This study looks at whether tezepelumab, a medicine for severe asthma, increases the risk of serious heart problems like heart attack or stroke. It will follow over 16,000 teens and adults with severe asthma who take tezepelumab or standard treatment. The goal is to compare heart…

This study follows 200 Chinese patients with chronic sinusitis and nasal polyps after they have surgery. Researchers will track symptoms, quality of life, and disease control for one year using questionnaires and exams. The goal is to understand real-world outcomes and treatment …

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. The drug is given as a liquid by mouth or through a vein. The study also checks if people can reliably measure their kidney funct…

This study measures how chronic lymphocytic leukemia (CLL) patients feel and function while taking the drug acalabrutinib in everyday life, not just in a controlled trial. Researchers will review medical records of 120 adults in France who started acalabrutinib, tracking their qu…

This study will collect information from about 9,000 adults in Russia whose asthma is not well controlled. Researchers will look at patient backgrounds, treatments, and lab results to better understand the disease. No new treatments are being tested—the goal is to learn more abou…

This study aims to learn how hypophosphatasia (HPP), a rare genetic bone disease, naturally progresses over time in children and adults in Russia. Researchers will collect information from 55 participants, including medical history, physical exams, lab tests, and questionnaires. …

This study tracks 50 adults with chronic lymphocytic leukemia (CLL) who are starting acalabrutinib alone (no other cancer drugs) to see how long they stay on treatment and why they might stop. It collects real-world data on effectiveness and side effects, filling a knowledge gap …

This study is observing about 4,490 adults with liver or bile duct cancers who are receiving durvalumab-based treatments as part of their regular medical care. Researchers want to see how long patients live and how well the treatment works outside of a clinical trial. The goal is…

This study is a safety check required by Korean health authorities after the drug capivasertib was approved for breast cancer. It will track about 130 patients in regular medical practice to find any side effects and see how well the drug works in the real world. The goal is to m…

This study looks at how ovarian cancer is currently treated in Brazil. Researchers will collect information from 250 patients to understand what surgeries, medicines, and genetic tests are being used. The goal is to find what is working well and what could be improved, so that fu…

This study is for 170 adults with a type of advanced breast cancer (HR+, HER2-). It aims to find how often a gene change called ESR1 appears in blood samples, and compare it to results from tumor tissue. Participants are in three groups: those who have had prior treatment, those …

This study looks at tumor samples from 350 adults with gynecological cancers (endometrial, ovarian, cervical, vulvar, vaginal) to measure a protein called HER2. Researchers want to find out how common high HER2 levels are in these cancers. The goal is to better understand the dis…

This study looks at how the drug capivasertib changes the way the body processes another drug called dextromethorphan. It involves 42 healthy adults who will take both drugs in a fixed order. The goal is to gather safety and dosing information, not to treat any disease.

This study uses a survey to find out what Chinese patients and doctors consider most important when choosing the first targeted therapy for stage IV non-small cell lung cancer. About 590 participants (patients and physicians) will answer questions about treatment benefits, side e…

This study will look at the genetic makeup of advanced endometrial cancer in 500 women in Russia. Researchers want to see how different gene patterns relate to the first treatments patients receive. The goal is to better understand the disease, not to test a new drug.

This study follows 600 adults in Germany with a type of advanced lung cancer that has certain high-risk gene mutations. They are receiving a three-drug combination (tremelimumab, durvalumab, and platinum chemo) as their first treatment. The goal is to see how well the treatment w…

This study watches how doctors in Russia currently treat adults with a rare muscle-weakening disease called generalized myasthenia gravis. It does not test any new medicine or procedure. Instead, it collects information from medical records and routine check-ups to understand pat…

This study tests how two experimental drugs (AZD0780 and AZD4954) affect each other's levels in the blood of 32 healthy adults. Participants take single doses of each drug alone and together. The goal is to gather safety and drug interaction information, not to treat any disease.

This observational study follows 442 pregnant women with moderate-to-severe lupus to see if taking the drug anifrolumab during pregnancy affects the health of mothers or their babies. Researchers will compare those exposed to the drug with those who are not. The goal is to gather…

This study reviews medical records of 200 people diagnosed with a rare blood and kidney disease called aHUS in Egyptian hospitals. Researchers want to understand how the disease affects patients, how it is treated, and what the long-term outcomes are. The goal is to improve early…

This study will observe and collect information from medical records of 200 adults with advanced non-small cell lung cancer (NSCLC) in Brazil. Researchers want to understand patient characteristics, which treatments doctors choose first, and whether those choices follow national …

This study looks at how the drug saruparib moves through the body in people with advanced solid tumors that have not responded to standard treatments. Eight participants will receive the drug by mouth and by vein to measure how much reaches the bloodstream and how it is broken do…

This study looks at how the drug capivasertib is processed in people with moderate liver impairment compared to those with healthy livers. About 20 participants will receive a single dose, and researchers will measure drug levels and safety. The goal is to understand if liver pro…

This study is for healthy adults to test how well andexanet reverses the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. Researchers will measure blood clotting activity after giving these drugs. The study do…

This study looks at 5,000 adults in Russia who have severe asthma that is not well controlled. Researchers will collect information on the treatments patients are already using and their health details. No new medicines or procedures are given. The goal is to better understand cu…

This study will observe 600 adults in Russia with bladder cancer to see what treatments they receive and how often their tumors have HER2 or PD-L1 markers. It does not test a new drug but aims to understand real-world care patterns and outcomes. No direct benefit to participants …

This study monitors the safety of eplontersen in pregnant or breastfeeding individuals with transthyretin amyloidosis and their babies. It does not test a new treatment but collects real-world data on pregnancy outcomes and infant health. About 10 participants will be followed to…

This study looks at a chronic lung condition called non-cystic fibrosis bronchiectasis, where airways are damaged and widened, causing cough and infections. Researchers will study 320 adults in China, including healthy volunteers, to find biomarkers and disease patterns. The goal…

This study reviews medical records of 150 Chinese adults with advanced papillary kidney cancer who received sunitinib or sorafenib as their first treatment. The goal is to see how long the drugs control the cancer in real-world settings. No new treatments are given; researchers s…

This study is a large registry that will collect information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments patients rec…

This study looks at how much of the lupus drug anifrolumab passes into breast milk and into the baby's blood. It will enroll 16 nursing mothers with lupus who are already taking the drug. The goal is to gather safety information, not to test a new treatment.

This study is an early-stage trial to check the safety of a new drug called AZD4954. It involves healthy volunteers and people with high cholesterol (dyslipidemia). Researchers will give single and multiple doses to see how the drug moves through the body and if it causes any sid…

This early-stage study tests whether a new drug called AZD3974 is safe and how it moves through the body. About 176 healthy adults, including people of Japanese and Chinese descent, will take either the drug or a placebo. The goal is to check for side effects and measure drug lev…

This study will review health records of up to 60,000 people with lung cancer in Alberta and Ontario to understand how the disease is treated, what it costs, and what outcomes patients experience. It aims to describe current treatment patterns, survival rates, and healthcare use.…

This study is a registry that will follow 3,000 Chinese adults with chronic kidney disease (CKD) to see how they are treated in real life and what happens to their health over time. It does not test a new drug or treatment, but simply collects information to better understand the…

This study is observing over 52,000 people with ATTR amyloidosis to learn about their disease from diagnosis through treatment. Researchers will collect information from medical records to see how the disease progresses, what treatments are used, and how it affects quality of lif…

This study aims to find out how many children and teens in Russia have a rare genetic condition called lysosomal acid lipase deficiency (LAL-D). Researchers will check kids with certain warning signs, like an enlarged liver or abnormal cholesterol levels, to see if they have the …