Massive trial aims to settle debate: which common surgery drug saves kidneys?
NCT ID NCT06802224
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two standard blood pressure medications, norepinephrine and phenylephrine, given during major non-cardiac surgery to prevent acute kidney injury. About 18,000 adults having surgery lasting at least two hours will be included. Hospitals will alternate which drug they use each month, and researchers will track kidney and heart outcomes using routine medical data.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Henry Ford Health
RECRUITINGDetroit, Michigan, 48202, United States
Contact Email: •••••@•••••
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Health Network
RECRUITINGToronto, Ontario, M5G 2C4, Canada
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Maryland
RECRUITINGCollege Park, Maryland, 20742, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
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Contact Email: •••••@•••••
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
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Contact Email: •••••@•••••
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Wake Forest University School of Medicine
RECRUITINGWinston-Salem, North Carolina, 27101, United States
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Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
norepinephrine and phenylephrine
What this could lead to
If this trial succeeds, it could identify which standard blood pressure drug is better at preventing kidney and heart complications after major surgery.
What could go wrong
This is a large pragmatic trial, but it compares two already-approved drugs, so the difference may be small. Results may not apply to all surgery types or patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.