ANESTHESIA

This study tests three different approaches during donor anesthesia to help the transplanted kidney work better after surgery. Researchers will compare mannitol, dopamine, and extra fluids to see which one improves kidney function the most. The study involves 60 adults with end-s…

This study compares light versus deep general anesthesia in older adults (65+ or 55+ for Indigenous peoples) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion after surgery—and long-term thinking problems. About 2,766 participants wi…

This study compares two common blood pressure medications, norepinephrine and phenylephrine, given during major surgery to prevent kidney injury afterward. About 18,000 adults having non-cardiac surgery lasting at least two hours will be included. Hospitals will switch which drug…

This study is testing whether interventional radiologists can safely give deep sedation (using ketamine) for certain procedures that normally require general anesthesia. The goal is to see if this approach works well enough to avoid stopping early or switching to general anesthes…

This study tests if itopride, a drug that helps the stomach empty faster, can reduce the risk of food or liquid getting into the lungs during anesthesia for people taking semaglutide. Semaglutide slows stomach emptying, which can be dangerous before surgery. The trial will enroll…

This study compares two ways to manage pain after laparoscopic colorectal surgery. One group gets a standard abdominal nerve block, and the other gets that block plus an additional block near the tailbone. The goal is to see if the combination reduces pain and the need for strong…

This study tests whether adding dexmetomidine to standard spinal anesthesia (bupivacaine) improves pain relief and recovery for women having planned C-sections. About 300 full-term pregnant women aged 20-35 will be randomly assigned to receive either the standard drug alone or th…

This study tests whether using epidural anesthesia instead of general anesthesia can improve patient satisfaction and reduce complications during laparoscopic kidney removal. About 80 adults scheduled for this surgery will be randomly assigned to one of the two anesthesia methods…

This study compares two pain management techniques for people having total knee replacement. One group gets a single injection to numb the knee area, while the other gets a continuous numbing medicine through a small tube. The goal is to see which method reduces the need for opio…

This study tests whether adding two common drugs (dexmedetomidine and lidocaine) to general anesthesia can help patients recover faster and with less pain after major surgery. About 100 adults having planned non-cardiac surgery will take part. The main goal is to see if a larger …

This study tests a new type of nerve block (deep rectus sheath block) to reduce pain after laparoscopic gallbladder removal. 60 adults scheduled for this surgery will receive the block, and researchers will measure how much morphine they need for the first 24 hours. The goal is t…

This study looks at how different strengths of the numbing medicine ropivacaine affect how fast and how long ankle blocks work for people having bunion surgery. About 174 adults will be randomly assigned to receive one of three concentrations. The goal is to find the best strengt…

This study compares two methods of pain control for people having hip replacement surgery. One method is a nerve block (PENG block) given before surgery, and the other is injecting pain medicine into the surgical area during the operation. The goal is to see if the nerve block wo…

This study looks at 100 women having gynecologic surgery to see if a mix of intravenous and inhaled anesthesia helps them recover better than inhaled anesthesia alone. Recovery is measured using a questionnaire about pain, comfort, and daily activities. The goal is to find which …

This study compares two methods of calculating propofol (anesthesia) doses for people with severe obesity (BMI over 35) undergoing surgery. The goal is to see if using an adjusted body weight instead of total body weight reduces the risk of overdose and speeds recovery. About 46 …

This study tests two common drugs, labetalol and lignocaine, to see which one better prevents sudden spikes in heart rate and blood pressure when a breathing tube is placed during gallbladder surgery. About 116 adults having planned gallbladder removal will receive one of the dru…

This study looks at two different ways to numb the back teeth of children aged 6-12 before getting a filling. One method uses a digital device to inject anesthetic into the bone, while the other uses a manual injection into the gum. The goal is to see which technique causes less …

This study tests whether using no opioids during breast cancer surgery can lower pain and the need for painkillers after the operation, compared to standard anesthesia. About 200 adults having breast cancer surgery will take part. The goal is to see if this approach leads to fewe…

This study tests whether adding two nerve blocks (BAP and TAP) to standard pain relief can lower pain and reduce opioid use in the first two days after minimally invasive left-sided colorectal surgery. About 140 adults undergoing elective laparoscopic surgery will be randomly ass…

This study tests whether a virtual reality simulation that mimics an MRI scan can help children aged 4-18 stay calm enough to complete the scan without anesthesia. About 288 children will be randomly assigned to either VR preparation, a booklet, or usual care. The main goal is to…

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one causes fewer problems like low blood pressure, low oxygen, or nausea during endoscopy. About 200 adults with higher health risks will take part. The goal is to find the sa…

This study compares two methods of numbing the shoulder after total shoulder replacement: a continuous nerve block using a small tube (catheter) versus a single injection of a long-lasting painkiller (Exparel). About 56 adults having reverse shoulder replacement will be randomly …

This study compares giving oral methadone before heart surgery versus intravenous methadone during anesthesia to see which better controls post-surgery pain. About 100 adults having elective heart surgery will participate. The goal is to reduce the total amount of opioids needed …

This study compares two medications, dexmedetomidine and dexamethasone, added to a standard nerve block for upper arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for extra painkillers. About 44 adults aged 18-70 will take pa…

This study compares three different medicines (dexmedetomidine, fentanyl, and magnesium sulphate) added to standard anesthesia for people having brain tumor surgery. The goal is to see which one reduces the amount of main anesthetic needed and helps patients wake up faster for a …

This study tests if the drug Aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either Aprepitant or standard care. The goal is to see if fewer children need extra anti-nausea medication after…

This study aims to see if brain wave patterns, measured before surgery, can predict the amount of anesthesia needed to reach deep sleep. About 110 adults having surgery will take part. Researchers will record brain activity and thinking skills before anesthesia, then track the do…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and heart problems. The goal is to identify genetic factors that could h…

This study looks at whether a specific method of removing the breathing tube (extubation) after abdominal surgery can help prevent lung problems like collapsed lungs or pneumonia. It involves 270 adults at moderate or high risk for these complications. The goal is to find the bes…

This study aims to create a portable, radiation-free software that uses facial recognition and neck movement analysis to predict how difficult it will be to place a breathing tube during anesthesia. Researchers will enroll 1800 adults undergoing planned surgery to test the softwa…

This study looks at whether military medics who have little experience with intubation can safely use the SaCoVLM™ video laryngeal mask airway. The research has two parts: first, training on a simulator, then using the device on sedated patients having elective surgery. The goal …

This small study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a combination of brain stimulation and EEG can measure brain complexity during sedation without…

This study tests a new method to track how deep anesthesia is during surgery by measuring drugs in a patient's breath. Researchers will enroll 500 adults having surgery under general anesthesia. The goal is to see if breath analysis can replace or improve standard brain wave moni…

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity and affect memory and pain perception. Healthy adults aged 18-59 will have MRI brain scans and EEG recordings while receiving the drugs alone or together. The goal is to understand h…

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each person's needs can keep blood pressure more stable than giving a standard starting dose. It involves 320 adults aged 55 and older having planned non-heart surgery. The goal is to f…

This study looks at children who had surgery 1-2 years ago to see if using a brain monitor (pEEG) during anesthesia changed their long-term behavior. Researchers will compare kids who had pEEG-guided anesthesia with those who had standard care. The goal is to understand if better…

This study tests whether a device called CoreSys can help anesthesiologists better manage stress during abdominal hysterectomy. The stress response to surgery can cause inflammation and slow recovery. Thirty women having the procedure will be randomly assigned to standard anesthe…

This study looks at whether blocking light during surgery can change how much anesthesia medicine is needed. 66 adults having general anesthesia will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asleep, and time to wake up t…

This study aims to count every anesthesia-related activity in Catalonia over 14 days, including surgeries, ICU care, pain management, and deliveries. Over 13,000 patients will be included without any restrictions. The goal is to understand current workload and plan future resourc…

This study compares a new AI-powered chatbot (PEAR) with standard face-to-face conversations for explaining anesthesia risks before surgery. The goal is to see if the chatbot helps patients understand risks better and feel less anxious. About 120 adults having elective surgery wi…

This study looks at whether spinal or general anesthesia leads to fewer lung problems after delayed hip surgery in people aged 65 and older. Forty participants will have their oxygen levels and lung function measured after surgery. The goal is to find out which type of anesthesia…

This study aims to find out how often heart injury occurs after lower back surgery and what makes some patients more at risk. Researchers will follow 180 adults for 30 days after their operation, checking for signs of heart damage. The goal is to better understand and possibly pr…

This study watches blood sugar levels in over 6,500 children aged 1 month to 18 years who are fasting before planned surgery with anesthesia. The goal is to find a clear definition of dangerously low blood sugar (hypoglycemia) and understand which children are most at risk. No ne…

This study looks at how the heart and blood vessels change when people receive general anesthesia for surgery. Researchers want to understand why some people develop low blood pressure after being put to sleep. They will use ultrasound to measure heart function in 250 adults befo…

This study uses brain scans to understand how the sedative remimazolam changes brain activity, memory, and pain perception. Healthy adults aged 18-59 will receive the drug and undergo functional MRI while performing memory tasks and receiving mild pain stimuli. The goal is to lea…

This study observes how well-controlled blood sugar (measured by HbA1c) affects brain oxygen levels during surgery in people with diabetes. Researchers will monitor 80 adults undergoing urologic surgery to see if long-term glucose control relates to brain oxygen and recovery. Thi…

This study looks at how small amounts of carbon monoxide in the blood during anesthesia affect certain proteins linked to inflammation and cell health. Researchers will measure these proteins in 120 adults having surgery. The goal is to understand if low carbon monoxide levels ca…

This study tests a new, compact version of a computer-controlled system that delivers anesthesia during surgery. The system automatically adjusts the medicine based on the patient's brain activity. Researchers will compare the new version to an older one in 150 adults having non-…

This study looks at how the body processes anesthetics and painkillers in children and teenagers up to age 18. Researchers will measure drug levels in the blood to understand how these medicines behave differently in young people. The goal is to make dosing safer and more effecti…

This study watches how a standard dose of dexamethasone, a drug often given during surgery, changes blood sugar levels in 100 adults having non-cardiac operations. Researchers will use a continuous glucose monitor (CGM) on the arm to track sugar levels for 10 days after surgery, …

This study looks at whether how active you are before surgery can help predict complications and death after the operation. Researchers will ask 50,000 adults about their physical activity and follow their recovery. The goal is to see if activity level adds useful information bey…

This study is a registry that will gather detailed information from up to 50,000 people who receive blood products during emergency bleeding while under anesthesia. The goal is to analyze how blood clotting and other measures change during transfusion, and to track outcomes like …

This study looks at whether a non-invasive lung maneuver can help doctors predict if a child under general anesthesia will benefit from receiving fluids. The goal is to avoid giving unnecessary fluids when they won't help. The study will include 48 children having surgery at Bost…

This study looks at two types of anesthesia—conscious sedation and general anesthesia—used during painless stomach exams in frail adults aged 65 and older. The goal is to see which method causes fewer heart-related problems like abnormal heart rate or blood pressure changes. Abou…

This study looks at whether using positive words to describe an epidural procedure can reduce the pain a person feels. Researchers will compare positive versus negative phrasing in 30 first-time mothers receiving an epidural. The goal is to see if simple language choices can impr…

This study looks at a new, less invasive method to track heart function during cardiac ablation, a procedure that fixes irregular heartbeats. Researchers will enroll 27 adults to see if this monitoring technique provides useful information without the need for more invasive tools…

This study compares two ways of using a breathing machine (volume-controlled vs. pressure-controlled ventilation) during laparoscopic gynecologic surgery. The goal is to see which method better protects the brain and lungs when patients are placed head-down and the abdomen is fil…

This study tests a new anesthesia method for heart bypass surgery that aims to be better for patients and the planet. About 116 adults having planned bypass surgery will be split into two groups: one gets the new 'optimized recovery' technique, the other gets standard care. Resea…

This study follows 2000 adults who are having weight-loss surgery to understand how pain and daily activities change afterward. Researchers will ask patients about their pain levels, medication use, and any lasting effects on their quality of life. The goal is to learn what influ…

This study looks at whether the kind of anesthesia used during lung cancer surgery affects the chances of the cancer coming back. About 5,384 people having surgery for early-stage non-small cell lung cancer will be randomly assigned to receive either inhaled gas anesthesia or int…

This study looks at how a low dose of nitrous oxide (laughing gas) changes the way the brain processes pain and forms memories. Healthy volunteers will have two brain scans using fMRI, once with the gas and once without, while receiving mild painful stimulation. The goal is to un…

This study looks at whether changing the amount of carbon dioxide (CO2) in the blood affects how deeply asleep children are during intravenous anesthesia. Researchers will measure brain activity in 100 children aged 3-11 undergoing minor procedures. The goal is to see if higher C…

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will look at problems like nausea, low blood pressure, and kidney injury. The goal is to improve fasting guidelines for the millions of people who have procedures each y…