Brain scans may reveal best painkiller for knee arthritis

NCT ID NCT06245109

First seen May 03, 2026

Summary

This study aims to find out if brain-based tests can predict who will get pain relief from common knee osteoarthritis treatments. About 180 adults with knee pain will be randomly assigned to take duloxetine, celecoxib, or a placebo for 20 weeks. Researchers will use brain MRIs, knee X-rays, blood tests, and pain sensitivity checks to look for clues that predict treatment success.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.