Could stenting after clot removal improve stroke recovery?
NCT ID NCT05611242
First seen Jan 11, 2026
Summary
This phase 3 trial tests whether adding a carotid artery stent to standard clot removal (thrombectomy) helps people with acute ischemic stroke caused by a blockage in the internal carotid artery. About 404 adults aged 18-79 will be randomly assigned to receive either clot removal plus stenting or clot removal alone. The main goal is to see if the combined approach leads to less disability 90 days after the stroke.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Albany Medical College
RECRUITINGAlbany, New York, 12208, United States
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Allegheny Health Network Research Institute
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Ascension/Alexian Brothers Health System
RECRUITINGChicago, Illinois, 60606, United States
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Baptist Health Research Institute
RECRUITINGJacksonville, Florida, 32207, United States
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Baptist Healthcare Systems, Inc
RECRUITINGLexington, Kentucky, 40299, United States
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Boca Raton - Baptist Health
RECRUITINGBoca Raton, Florida, 33486, United States
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02118, United States
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Bronson Methodist Hospital/Western Michigan University Homer Stryker M.D. School of Medicine
RECRUITINGKalamazoo, Michigan, 49007, United States
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California Pacific Medical Center/Mils Peninsula Medical Center
RECRUITINGSan Francisco, California, 94107, United States
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DHR Health Institute for Research and Development
NOT_YET_RECRUITINGEdinburg, Texas, 78539, United States
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Delray Medical Center
RECRUITINGDelray Beach, Florida, 33484, United States
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RECRUITINGGlendale, California, 91206, United States
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HCA Houston Kingwood
RECRUITINGHouston, Texas, 77004, United States
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RECRUITINGIndianapolis, Indiana, 46202, United States
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JFK University Medical Center
RECRUITINGEdison, New Jersey, 08837, United States
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Louisiana State University Health Sciences Center at Shreveport
RECRUITINGShreveport, Louisiana, 71103, United States
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McLaren Flint
RECRUITINGFlint, Michigan, 48532, United States
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McLaren Macomb
RECRUITINGMount Clemens, Michigan, 48043, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Mercy Health St. Vincent Medical Center
RECRUITINGToledo, Ohio, 43608, United States
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Michigan State University
RECRUITINGLansing, Michigan, 48912, United States
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Mobile Infirmary Medical Center
RECRUITINGMobile, Alabama, 36607, United States
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Mount Sinai Hospital
RECRUITINGNew York, New York, 10029, United States
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Munster Community Hospital
RECRUITINGMunster, Indiana, 46321, United States
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Northwell Health- South Shore University Hospital
RECRUITINGBay Shore, New York, 11706, United States
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Northwestern Medicine Central DuPage Hospital
RECRUITINGWinfield, Illinois, 60190, United States
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Ochsner Medical Center
RECRUITINGNew Orleans, Louisiana, 70121, United States
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OhioHealth Research Institute
RECRUITINGColumbus, Ohio, 43214, United States
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Orlando Health, Inc.
RECRUITINGOrlando, Florida, 32806, United States
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Piedmont Healthcare
RECRUITINGAtlanta, Georgia, 30309, United States
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Pomona Valley
RECRUITINGPomona, California, 91767, United States
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Rutgers, The State University
RECRUITINGPiscataway, New Jersey, 08854, United States
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SSM Health DePaul Hospital
RECRUITINGSt Louis, Missouri, 63044, United States
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Semmes-Murphey Foundation
RECRUITINGMemphis, Tennessee, 38120, United States
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St. Mary's Medical Center
RECRUITINGWest Palm Beach, Florida, 33407, United States
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Sutter Institute for Medical Research
NOT_YET_RECRUITINGSacramento, California, 95816, United States
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University of California, Irvine
RECRUITINGIrvine, California, 92697, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
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University of Florida Health Jacksonville
RECRUITINGJacksonville, Florida, 32209, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Massachusetts
RECRUITINGWorcester, Massachusetts, 01655, United States
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University of Miami School of Medicine
RECRUITINGMiami, Florida, 33136, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of South Florida
RECRUITINGTampa, Florida, 33606, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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University of Washington
NOT_YET_RECRUITINGSeattle, Washington, 98195, United States
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Valley Medical Center
RECRUITINGRenton, Washington, 98055, United States
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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WellSpan Health
RECRUITINGYork, Pennsylvania, 17403, United States
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WellStar Health System, Inc
RECRUITINGMarietta, Georgia, 30062, United States
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West Virginia Univeristy
RECRUITINGMorgantown, West Virginia, 26506, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mechanical thrombectomy with carotid stenting and antiplatelet therapy
What this could lead to
If successful, this could establish a better standard treatment for certain types of severe stroke, potentially reducing long-term disability.
What could go wrong
This is an early-stage trial with 404 participants, so results may not apply to all stroke patients. The added stenting procedure carries risks like bleeding or vessel injury.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.