ACUTE ISCHEMIC STROKE

This study tests a new device called the RapidPulse Aspiration System to remove blood clots from the brains of people having a severe stroke. About 170 adults aged 18 to 80 will be treated within 8 hours of their first symptoms. The goal is to see if the device can safely restore…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency clot removal improves recovery in people with severe stroke caused by a large blockage in the front part of the brain. About 692 adults who can receive clo…

This study tests whether adding the antibiotic minocycline to standard clot-removal treatment helps people recover better from a severe stroke in the back of the brain. About 234 adults who had a successful clot removal will receive either minocycline or a placebo within 24 hours…

This study tests whether the antibiotic minocycline can help people recover better after a stroke caused by a large blocked artery. Even when doctors successfully remove the clot, many patients still have disability. The drug may reduce brain inflammation and damage. About 860 ad…

This study compares two emergency treatments for people having a severe stroke caused by a blockage in both the neck and brain arteries. One group gets standard clot removal plus a stent to open the neck artery; the other gets clot removal alone. The goal is to see which approach…

This study looks at whether adding evolocumab (a PCSK9 inhibitor) to standard statin therapy helps people recover better after a stroke caused by large-artery hardening. About 1000 adults aged 18-80 with moderate stroke symptoms will be followed for 90 days to check improvements,…

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 1060 adults who had a major stroke will receive either the steroid or a placebo through an artery and then through a vein for three d…

This study tests an experimental drug called HRS-7450 in 208 people who have had an acute ischemic stroke and can be treated within 4.5 to 24 hours after symptoms start. The goal is to see if the drug helps patients recover better than a placebo, measured by their ability to perf…

This study tests whether removing a blood clot from the brain (endovascular thrombectomy) plus standard medical care helps people who had a severe stroke 24 to 72 hours earlier. About 408 adults aged 18-85 with large-vessel blockage will be randomly assigned to get the procedure …

This study tests whether adding a clot-dissolving medicine directly into the brain's arteries during standard stroke treatment helps people recover better after a stroke caused by a medium-sized blockage. About 530 adults with acute ischemic stroke will be randomly assigned to ge…

This study tests a drug called JX10 in people who have had a stroke and arrive at the hospital 4.5 to 24 hours after symptoms start. The goal is to see if JX10 can improve recovery and reduce disability compared to a placebo. About 740 adults aged 18 to 90 with certain types of s…

This study tests whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke can prevent early neurological decline. About 429 adults with moderate to severe artery narrowing in the brain will be randomly assigned to re…

This study tests a new medicine called QD202 in people who have had an acute ischemic stroke and are receiving standard clot-busting therapy. The goal is to see if QD202 is safe and helps improve recovery. About 120 adults aged 18-85 will receive either QD202 or a placebo as an I…

This study looks at whether slightly raising blood pressure after a stroke clot removal procedure helps patients recover better. About 176 adults who had a stroke and whose blood pressure stayed low after the procedure will be randomly assigned to either a standard blood pressure…

This study looks at whether giving both clopidogrel and aspirin for 21 days after a stroke is safer and more effective than aspirin alone at preventing another stroke. About 200 adults who recently had a stroke and are at low bleeding risk will take part. The goal is to see if th…

This study tests a new medicine called SHPL-49 given through a vein to people who have had a stroke caused by a blood clot. The goal is to see if it helps them recover better and have less disability 90 days later. About 1,096 adults aged 18-80 who are already receiving standard …

This study tests whether giving albumin, a protein found in blood, along with standard clot-removal treatment helps people recover better after a severe stroke. About 1,200 adults aged 18-80 with a large-vessel stroke in the front part of the brain will be enrolled. The goal is t…

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. About 54 adults with moderate to severe stroke will receive either the stem cells or a placebo. Researchers will check safety and whether the treatment helps recovery over two years.

This study tests a new device called the CONDA stent retriever in 50 people who have had a stroke caused by a large blood clot in the brain. The goal is to see if the device can safely reach and remove the clot to restore blood flow within 24 hours of symptoms starting. Participa…

This study tests a new anti-clotting drug called TBO-309 in 80 people who have had a stroke from a blocked artery. The drug is given along with standard treatments to see if it can safely prevent the artery from blocking again. The main goal is to check for any serious bleeding i…

This study tests a new drug, MT200605, in 360 people who had a stroke within the last 24 hours. The drug aims to protect brain cells and reduce damage. Participants receive either a low, medium, or high dose of the drug or a placebo, along with standard care. The main goal is to …

This study looks at whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 adults with a specific type of stroke will either get the procedure plus standard care or standard care alone. The goal …

This study tests whether giving the blood thinner tirofiban soon after standard clot-busting medication helps people recover better from a stroke. About 1,084 adults who had a stroke and received tenecteplase will be randomly assigned to get tirofiban or a placebo within 6 hours.…

This study tests a new medicine called LT3001 for people who have had a stroke caused by a blood clot. The goal is to see if it is safe and helps recovery. About 300 adults aged 18 to 80 who can start treatment within 24 hours of their stroke will take part. Half will get the dru…

This study tests a clot-busting drug called tenecteplase in Chinese adults who had a stroke more than 4.5 hours ago. Participants must have a certain amount of brain damage visible on a CT scan. The goal is to see if the drug helps them recover without disability 90 days later. A…

This study compares a procedure to open a blocked internal carotid artery in the neck (endovascular treatment) plus standard medical care versus standard care alone for people who have had a mild or severe stroke. About 200 adults with acute ischemic stroke and a mismatch between…

This study tests whether a new drug, Aleeto, can help people recover from a moderate to severe stroke better than a placebo. About 192 adults aged 30 to 80 who had a stroke within the last 72 hours will receive either Aleeto or a placebo. The main goal is to see if Aleeto improve…

This study looks at whether stroke patients who take a type of blood thinner called FXa inhibitors can safely receive a standard clot-busting drug (IVT). Current guidelines say no, due to bleeding risk, but new evidence suggests it may be safe. The trial will compare recovery and…

This study is for people who have had a recent stroke caused by a blood clot. Many cannot receive standard clot-busting drugs or surgery. Researchers are testing a safe, weak electrical current applied to the scalp to increase blood flow to the brain and save at-risk tissue. The …

This study tests whether adding a drug called tirofiban early after standard clot-busting treatment (tenecteplase) helps people recover better from a stroke. About 348 adults who had a stroke and received tenecteplase will be enrolled. The goal is to see if the combination reduce…

This study tests whether adding a drug called tirofiban after standard clot-busting treatment helps people who have had a stroke and are not improving enough. About 976 adults with moderate to severe stroke will receive either tirofiban or a placebo for 24 hours, then standard an…

This study tests whether exosomes (tiny particles) from stem cells can help people recover from a recent stroke. About 29 adults aged 18-70 with moderate to severe stroke will receive either the exosomes or a placebo. The goal is to check safety and see if it improves daily funct…

This study tests whether giving aspirin within 3 hours of clot-busting medication for acute ischemic stroke can help patients recover better. About 1,184 adults who still have significant stroke symptoms after the initial treatment will receive either aspirin or a placebo. The go…

This study looks at how safe and effective the EmboTrap II device is at removing blood clots in people having a severe stroke. About 100 participants will be observed after the device is used to open blocked arteries in the brain. The goal is to see if it can restore blood flow w…

This study tests whether giving a clot-busting drug called tenecteplase before transferring patients with a severe type of stroke (basilar artery occlusion) to a specialized hospital can improve recovery. The trial involves 316 adults who had a stroke 4.5 to 24 hours earlier. The…

This study tests a new drug called sovateltide for people who have had a stroke caused by a blood clot in the brain. The goal is to see if the drug helps improve recovery and reduce long-term disability. About 514 adults aged 18 to 80 will receive either the drug or a placebo, al…

This study tests a drug called rhTNK-tPA (Mingfule) in people who have had a severe stroke caused by a large blood clot in the brain. Unlike standard treatment, which must be given within 4.5 hours, this drug is given 4.5 to 24 hours after symptoms start. The goal is to see if it…

This study tests whether adjusting blood pressure differently during standard clot-busting treatment for stroke can lower the risk of dangerous brain bleeding. About 340 adults with acute ischemic stroke and high blood pressure will be randomly assigned to either the new or usual…

This study tests a drug called TAK-755 in adults who have had a stroke caused by a blood clot. The goal is to see if it is safe and helps reduce disability compared to a placebo. About 222 participants will receive either TAK-755 or a placebo once, along with standard stroke care…

This study tests whether a single infusion of stem cells from donated umbilical cord blood can help people recover function after a moderate-to-severe stroke. Eighty adults who had a stroke within the past 4 weeks and cannot receive standard clot-busting treatment will be randoml…

This study tests whether removing a blood clot from the brain up to 72 hours after a stroke can help patients recover better than standard care. About 382 adults with severe strokes caused by a large blockage will be randomly assigned to get the procedure or not. Doctors will che…

This study is testing a device called the NeVa stent retriever to remove blood clots in people having a severe stroke. The goal is to restore blood flow to the brain in a single pass, within 24 hours of symptoms starting. About 600 adults with large artery blockages will be enrol…

This study looks at whether starting heart rhythm control therapy early after a stroke caused by atrial fibrillation can prevent another stroke, heart-related death, or hospital stays. About 1,746 adults who had a stroke and were recently diagnosed with atrial fibrillation will t…

This study tests a safe, non-invasive technique called remote ischemic conditioning (RIC) for people having a stroke caused by a large clot. RIC involves briefly inflating a blood pressure cuff on the arm or leg in cycles, which may protect the brain from damage during and after …

This study tests a new tool called the Ceretrieve device, designed to remove blood clots from brain arteries in people having a severe stroke. About 132 participants will receive the device within 24 hours of symptoms starting. Researchers will check if the device safely restores…

This study is testing a new catheter device designed to remove blood clots from small, hard-to-reach brain arteries in people having a stroke. About 57 adults who have had a stroke within the last 24 hours will be enrolled. The goal is to see if the device can safely restore bloo…

This study is for people who have had a moderate-to-severe stroke caused by a blockage in a medium-sized brain artery. It compares standard care plus a procedure that uses a thin tube to remove the clot versus standard care alone. The goal is to see if the procedure helps more pe…

This study tests whether giving a clot-busting drug directly into the brain's arteries can help people with medium-sized blockages causing stroke. About 382 adults who have had a stroke within the last 24 hours will receive either standard care or the drug, called rhTNK-tPA, thro…

This study tests whether adding the drug tirofiban to standard clot-removal treatment helps people recover better after a severe stroke caused by a blocked artery in the brain. About 716 adults who have had a stroke within the past 24 hours will receive either tirofiban or a plac…

This study tests whether a drug called tenecteplase can help people having a stroke who recently took blood thinners (DOACs). About 912 participants will receive either the drug or a placebo to see if it improves their recovery and ability to function after 90 days. The goal is t…

This study tests a new drug called BB-031 in people who have had a stroke caused by a blood clot in the brain. The goal is to see if the drug is safe and how the body handles it. About 228 participants will receive either the drug or a placebo within 24 hours of their stroke and …

This study looks at whether Angong Niuhuang Pills, made with different sources of cow gallstones, can help people recover from a recent stroke. About 100 adults aged 18-80 will take one of two pill versions or no pill, and their recovery will be tracked for 84 days. The goal is t…

This study compares a procedure to remove blood clots (endovascular therapy) with standard medication for people who have had a mild stroke caused by a large blocked artery in the brain. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within 24 hours of the…

This study tests a new drug called QHRD106 in people who have had a recent ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if the drug can help patients recover better and have less disability. About 320 adults aged 18 to 80 who have n…

This study tests whether using a platelet function test to choose the right anti-clotting drug can prevent another stroke in people who recently had a mild stroke or a mini-stroke. About 5,100 participants will be enrolled within 48 hours of their symptoms starting. Those whose b…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This study tests whether adding a drug called GM1 to the standard clot-removal procedure helps people recover better after a major stroke. About 868 adults with a blocked artery in the front part of the brain will receive either GM1 or a placebo. The goal is to see if more people…

This study tests whether telemedicine support can improve stroke care in basic-level hospitals with limited resources. Researchers will compare hospitals that receive remote expert guidance to those that do not. The goal is to see if more patients recover well after a stroke. Abo…

This study is testing a medical device designed to quickly restore blood flow in people having a severe stroke caused by a blocked artery. About 500 adults who are treated within 8 hours of their stroke symptoms starting will take part. The goal is to see how well the device reop…

This study tests whether placing a stent in a narrowed brain artery after removing a clot can improve recovery and reduce bleeding risk in stroke patients. About 342 adults aged 18-80 with severe stroke and significant artery narrowing will be enrolled. The approach combines stan…

This study looks at whether giving a clot-busting drug called Tenecteplase to stroke patients at a local hospital, before they are transferred to a specialized center for a procedure to remove the clot, can improve their recovery. The trial involves 572 adults with a specific typ…

This study tests an experimental drug called KPCXM18 in people who have had a stroke caused by a blood clot. The goal is to see if the drug helps patients recover better than a placebo. About 300 adults aged 18 to 80 will receive either the drug or a placebo within 12 hours of th…

This study tests a traditional Chinese herbal formula, Qingre Huatan, to see if it can prevent early neurological decline in people who have just had a stroke. About 72 adults who had a stroke within the last 48 hours and are at high risk of getting worse will receive either the …

This study tests if the clot-busting drug tenecteplase can help people who had a stroke more than 4.5 hours ago or woke up with stroke symptoms. About 1,325 adults with brain tissue that can still be saved will either get tenecteplase or standard care. Researchers will measure di…

This study tests whether tilting the head down 10-15 degrees before a clot-removal procedure can improve blood flow to the brain in people having a severe stroke. About 118 adults with a blocked middle cerebral artery will be randomly assigned to either the head-down tilt or stan…

This study looks at 100 people who recently had a stroke and need surgery to clear a blocked neck artery. Half will get regional anesthesia (awake but numb) and half will get general anesthesia (fully asleep). The goal is to see which method leads to fewer complications like anot…

This study looks at two different ways to keep patients comfortable and calm during a procedure to remove a blood clot from the brain after a stroke. The goal is to find out which method helps patients recover better and have fewer problems. About 810 adults having this emergency…

This study tests increasing doses of a clot-busting drug called urokinase in 24 adults who have had an ischemic stroke within the past 6 hours. The goal is to find the highest safe dose that works best, based on each person's weight. Researchers will watch for bleeding in the bra…

This study watches 150 people who had a stroke to see if ups and downs in blood pressure affect their recovery. Researchers will track brain scans and thinking skills to understand the link. The goal is to find new ways to treat blood pressure after a stroke.

This study is testing whether a mild electrical stimulation of a nerve in the ear can reduce brain injury and inflammation after a stroke caused by a blocked large artery. Researchers will measure markers of brain damage and inflammation in the blood of 65 participants. The goal …

This study looks at why some stroke patients still have poor outcomes even after successful clot removal. Researchers will compare MRI scans with brain tissue samples from 15 patients who need surgery to relieve brain swelling. The goal is to see if certain MRI signals indicate t…

This study aims to build an AI system that predicts the best rehabilitation approach for each stroke survivor. Researchers will collect data from 400 participants aged 65-80 who had a stroke 1-6 months ago. The AI will analyze clinical, brain imaging, and muscle activity data to …

This study compares two ways to reach blocked arteries in the back of the brain during a severe stroke: through the wrist (radial artery) or the groin (femoral artery). About 386 adults with a specific type of stroke caused by a blocked basilar artery will be randomly assigned to…

This worldwide study looks at a rare but serious complication—a blood vessel tear—that can happen during a stroke treatment called thrombectomy. Researchers will study 1000 patients to understand why these tears occur and how to better manage them. The goal is to create a simple …

This study is gathering information on how well BALT medical devices work in everyday medical practice for conditions like brain aneurysms, stroke, and other blood vessel diseases. Researchers will track safety, performance, and ease of use in up to 10,000 people. The goal is to …

This study looks at how a stroke can disrupt the body's automatic functions like heart rate and blood pressure. Researchers will use brain scans, blood tests, and heart monitoring in 100 people who recently had a stroke or a mini-stroke. The goal is to better understand these cha…

This study is looking for new ways to quickly and accurately diagnose strokes using blood and saliva tests. Researchers will study 650 adults who come to the emergency room with stroke symptoms within 24 hours. The goal is to find biological markers that can tell if a stroke is h…

This study looks at 129 people having emergency stroke treatment to see if monitoring brain blood flow during the procedure can help doctors know early on if the treatment will lead to a good recovery. Participants are followed for 90 days. The goal is to improve how we predict o…

This study collects blood, clots, and tissue from up to 1,000 people having stroke-related procedures. Researchers will analyze these samples to find biological markers and understand how stroke affects the body. The goal is to improve knowledge and help develop better, more pers…

This study is a large registry that will collect information from 1,000 people treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real-life settings, such as how completely aneurysms are closed or how well blood …