TREATMENT RESISTANT DEPRESSION
Clinical trials for TREATMENT RESISTANT DEPRESSION explained in plain language.
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New depression drug shows promise but study halted early
Symptom relief TerminatedThis study looked at the long-term safety and symptom relief of an experimental drug called AXS-05 in 181 adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants took the drug and were monitored for side effects and mood ch…
Matched conditions: TREATMENT RESISTANT DEPRESSION
Phase: PHASE2 • Sponsor: Axsome Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Depression drug trial halted early: what we know
Symptom relief TerminatedThis study tested the drug tianeptine in 38 adults with major depression that did not improve after at least two other treatments. Participants took tianeptine three times a day for 8 weeks. The goal was to see if it reduced depression symptoms and changed how the brain processes…
Matched conditions: TREATMENT RESISTANT DEPRESSION
Phase: PHASE4 • Sponsor: Jonathan A. Javitch, MD, PhD • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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New drug candidate for stubborn depression tested, but study halted early
Symptom relief TerminatedThis study tested whether MK-1942, when added to standard antidepressants, could help people with treatment-resistant depression. About 99 participants were planned, but the trial was terminated early. The goal was to measure changes in depression scores and safety.
Matched conditions: TREATMENT RESISTANT DEPRESSION
Phase: PHASE2 • Sponsor: Merck Sharp & Dohme LLC • Aim: Symptom relief
Last updated Jun 25, 2026 12:10 UTC