Olive oil tooth treatment tested in kids
NCT ID NCT07265089
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new root canal filling made from zinc oxide and ozonated olive oil against a standard material called Metapex in children aged 3-5 with cavities in their front teeth. Over 12 months, researchers will check for pain, swelling, and healing on X-rays. The goal is to see if the natural alternative works just as well.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- zinc oxide-ozonated olive oil
- What this could lead to
- If it works, this could offer a natural alternative for filling children's root canals, potentially reducing the need for more invasive treatments.
- What could go wrong
- This is a small, early-stage trial with only 52 children, so results may not apply to everyone. The new material might not heal as well as the standard one.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 52 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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3 to 5 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Children aged 3-5 years. 2. Primary anterior teeth requiring root canal treatment due to irreversible pulpitis. 3. Cooperative behavior child. 4. Parents provided written informed consent. - Exclusion Criteria: 1. Medically compromised children. 2. Tooth with advanced root resorption. 3. Non-restorable crown structures. 4. Tooth with abscess or fistula. 5. Allergies or hypersensitivity to any of the materials used e.g., zinc oxide, olive oil, or calcium hydroxide and Idoform (components of Metapex). 6. Unable to attend follow-up visits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate, Egypt