Zinc boosts botox: fewer needles for jaw pain?
NCT ID NCT07270042
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking zinc pills for four days before Botox injections can make the muscle-relaxing effect last longer in people with overactive jaw muscles. Twenty adults with jaw clenching or grinding will receive Botox in both masseter muscles, and half will also take zinc beforehand. Researchers will measure muscle activity and patient satisfaction over 12 weeks to see if zinc extends the treatment's benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- zinc gluconate and botulinum toxin A
- What this could lead to
- If it works, this could mean fewer Botox injections for people with jaw clenching or grinding, saving time and cost.
- What could go wrong
- This is a very small, early study with only 20 people, so results may not apply widely. Zinc might not extend Botox's effect as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants will be adults aged 18-60 years presenting with clinically confirmed masseteric hypertrophy or hyperactivity, as approved by EMG. Exclusion Criteria: * Pregnancy or lactation; * Patients have aminoglycosides or vit B12. * Prior BTX-A treatment to the masseter within the previous 12 months; * Neuromuscular disorders or hypersensitivity to BTX-A or zinc compounds; * Systemic illness affecting zinc metabolism (e.g., hepatic, renal, or metabolic disorders); * Active infection, inflammation, or cutaneous lesions at the injection site.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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lattakia University
Latakia, Syria