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Knee injection study halted early – limited data on pain relief

NCT ID NCT03110224

Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how well a procedure called Subchondroplasty (SCP) works for people with bone marrow edema in the knee. The procedure involves injecting a synthetic bone filler into the bone to relieve pain and improve function. The study planned to follow 516 patients but was terminated early, so the full picture of long-term benefits and risks is not available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AccuFill (calcium phosphate bone void filler)
What this could lead to
If successful, this procedure could offer a way to reduce knee pain and improve function for people with bone marrow edema, potentially delaying or avoiding more invasive surgery.
What could go wrong
The study was terminated early, so results are limited. The procedure involves injecting a synthetic material into bone, which carries risks like infection or the need for additional surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

516 people

The number who actually took part.

Started

Sep 2012

Finished

May 2023

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The SCP Observational Cohort Study will enroll either patients undergoing SCP or patients who have already had the SCP procedure for the treatment of BMLs where bone void filler is placed at the site of the BML (defect).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Surgeon considers patient appropriate for SCP procedure. 2. Patient has agreed to undergo the SCP procedure or has already undergone the procedure. 3. Subject is willing and able to sign a written consent form. 4. The subject has the mental capacity and the willingness to contribute follow-up outcome data. 5. Patient is willing and able to complete outcome forms in person or by phone, email or regular mail. Exclusion Criteria: 1\. Patient is not comfortable with speaking, reading, and understanding questions and providing responses in an available language for the PROs in the protocol.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone marrow edema

Contacts and locations

Locations

  • Allegheny Singer Research Institute

    Pittsburgh, Pennsylvania, 15212, United States

  • Associated Orthopedists

    Saint Clair Shores, Michigan, 48080, United States

  • Atlantis Orthopaedics

    Palm Beach Gardens, Florida, 33410, United States

  • Beaumont Health System

    Royal Oak, Michigan, 48073, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cascio Sports Medicine

    Lake Charles, Louisiana, 70601, United States

  • Denver-Vail Orthopedics

    Parker, Colorado, 80134, United States

  • Foundation for Orthopaedic Research and Education (FORE)

    Tampa, Florida, 33637, United States

  • Jordan-Young Institute

    Virginia Beach, Virginia, 23462, United States

  • New York University School of Medicine

    Huntington Station, New York, 11746, United States

  • Ohio State University

    Columbus, Ohio, 43221, United States

  • OrthoIndy

    Indianapolis, Indiana, 46143, United States

  • Orthopaedic Surgical Associates

    North Chelmsford, Massachusetts, 01863, United States

  • Southern Ortho

    Johns Creek, Georgia, 30097, United States

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