Knee injection study halted early – what we know so far
NCT ID NCT03110224
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 34 times
Summary
This study followed 516 people who had a Subchondroplasty procedure for bone marrow edema in the knee. The procedure involves injecting a calcium phosphate filler into the bone to relieve pain and improve function. Researchers measured pain levels, medication use, and any complications over time. The study was terminated early, so the full long-term picture is incomplete.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Allegheny Singer Research Institute
Pittsburgh, Pennsylvania, 15212, United States
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Associated Orthopedists
Saint Clair Shores, Michigan, 48080, United States
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Atlantis Orthopaedics
Palm Beach Gardens, Florida, 33410, United States
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Beaumont Health System
Royal Oak, Michigan, 48073, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cascio Sports Medicine
Lake Charles, Louisiana, 70601, United States
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Denver-Vail Orthopedics
Parker, Colorado, 80134, United States
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Foundation for Orthopaedic Research and Education (FORE)
Tampa, Florida, 33637, United States
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Jordan-Young Institute
Virginia Beach, Virginia, 23462, United States
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New York University School of Medicine
Huntington Station, New York, 11746, United States
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Ohio State University
Columbus, Ohio, 43221, United States
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OrthoIndy
Indianapolis, Indiana, 46143, United States
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Orthopaedic Surgical Associates
North Chelmsford, Massachusetts, 01863, United States
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Southern Ortho
Johns Creek, Georgia, 30097, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AccuFill (calcium phosphate bone void filler) injected into the knee bone
What this could lead to
If successful, this could confirm that the Subchondroplasty procedure provides lasting pain relief and improved knee function for people with bone marrow edema.
What could go wrong
This is an observational follow-up study, not a controlled trial, so results may be less reliable. The study was terminated early, which limits the data available.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.