Knee injection study halted early – limited data on pain relief

NCT ID NCT03110224

Terminated Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how well a procedure called Subchondroplasty (SCP) works for people with bone marrow edema in the knee. The procedure involves injecting a synthetic bone filler into the bone to relieve pain and improve function. The study planned to follow 516 patients but was terminated early, so the full picture of long-term benefits and risks is not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AccuFill (calcium phosphate bone void filler)
What this could lead to: If successful, this procedure could offer a way to reduce knee pain and improve function for people with bone marrow edema, potentially delaying or avoiding more invasive surgery.
What could go wrong: The study was terminated early, so results are limited. The procedure involves injecting a synthetic material into bone, which carries risks like infection or the need for additional surgery.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE MARROW EDEMA

Contacts and locations

Locations

Allegheny Singer Research Institute

Pittsburgh, Pennsylvania, 15212, United States
Associated Orthopedists

Saint Clair Shores, Michigan, 48080, United States
Atlantis Orthopaedics

Palm Beach Gardens, Florida, 33410, United States
Beaumont Health System

Royal Oak, Michigan, 48073, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Cascio Sports Medicine

Lake Charles, Louisiana, 70601, United States
Denver-Vail Orthopedics

Parker, Colorado, 80134, United States
Foundation for Orthopaedic Research and Education (FORE)

Tampa, Florida, 33637, United States
Jordan-Young Institute

Virginia Beach, Virginia, 23462, United States
New York University School of Medicine

Huntington Station, New York, 11746, United States
Ohio State University

Columbus, Ohio, 43221, United States
OrthoIndy

Indianapolis, Indiana, 46143, United States
Orthopaedic Surgical Associates

North Chelmsford, Massachusetts, 01863, United States
Southern Ortho

Johns Creek, Georgia, 30097, United States

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