Can a traditional chinese tablet reduce heart attacks and hospitalizations?

NCT ID NCT07110415

Disease control Sponsor: SPH Qingdao Growful Pharmacetical Co.,Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether Yangxinshi tablets can improve outcomes for people with coronary heart disease and heart dysfunction. About 2,700 participants aged 40-80 will receive the tablet or a placebo. The goal is to see if the tablets reduce serious heart events like death, stroke, or hospital readmission.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 2,708 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. For inpatients diagnosed with coronary heart disease (including acute coronary syndrome and chronic coronary syndrome), it is up to the doctor to decide whether to undergo revascularization and what kind of revascularization to use. 2. Patients aged between 40 and 80 years (inclusive), regardless of sex; 3. Patients with NYHA cardiac function classes II-IV; 4. Patients with NT-proBNP \> 125 pg/mL (or BNP\>35 pg/mL); 5. The syndrome differentiation in traditional Chinese medicine conforms to chest obstruction (qi deficiency and blood stasis syndrome) 6. Patients who voluntarily participated and signed an informed consent form. Exclusion Criteria: 1. Patients with STEMI within 3 days; 2. Patients at extremely high risk of NSTEMI (hemodynamic instability, cardiogenic shock, new-onset heart failure or aggravated heart failure, severe ventricular arrhythmia) 3. Patients with acute myocardial infarction complicated with cardiogenic shock, mechanical complications, respiratory failure and other multiple organ failure; 4. Patients with severe liver dysfunction (transaminase levels more than three times the upper limit of normal), renal insufficiency (eGFR \< 30mL/min/1.73m2), acute infectious diseases, and mental disorders;以上翻译结果来自有道神经网络翻译（YNMT）· 通用场景 5. Patients with drug-resistant hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg); 6. Pregnant or lactating women, or those planning pregnancy during the study period; 7. Patients who cannot tolerate 3 months of dual antiplatelet therapy; 8. Patients with allergic reactions or abnormal drug reactions to the study drug or any of its excipients; 9. Patients who have regularly taken Yangxinshi tablets and similar traditional Chinese medicine, Chinese patent medicine or traditional Chinese medicine decoction with the same curative effectin the past month; 10. Patients who have participated in other clinical drug trials within the last three months; 11. Patients with malignant tumors and other pathological conditions with an expected survival of less than 3 years; 12. Patients whom the investigator deems unsuitable for participating in the clinical trial.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac dysfunction Coronary heart disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

96 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Affiliated Hospital of Changchun University of Traditional Chinese Medicine
NOT_YET_RECRUITING

Changchun, Jilin, China
Affiliated Hospital of Shandong Second Medical University
NOT_YET_RECRUITING

Weifang, Shandong, China
Army Specialty Medical Center
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
Baoding No.1 Central Hospital
NOT_YET_RECRUITING

Baoding, Hebei, China
Beijing Hospital of Traditional Chinese Medicine
NOT_YET_RECRUITING

Beijing, Beijing Municipality, China
Beilun Branch of the First Affiliated Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITING

Ningbo, Zhejiang, China
Chengdu Wenjiang District People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, China
Chifeng Municipal Hospital
NOT_YET_RECRUITING

Chifeng, Neimenggu, China
Chongqing Emergency Medical Center
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
Chongqing General Hospital
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
Chongqing University Three Gorges Hospital
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
Dandong Central Hospital
NOT_YET_RECRUITING

Dandong, Liaoning, China
Daqing Oilfield General Hospital
NOT_YET_RECRUITING

Daqing, Heilongjiang, China
Dongfang Hospital,Beijing University of Chinese Medicine
NOT_YET_RECRUITING

Beijing, Beijing Municipality, China
Fudan University Minhang Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Fushun Central Hospital
NOT_YET_RECRUITING

Fushun, Liaoning, China
Fuxin Central Hospital
NOT_YET_RECRUITING

Fuxin, Liaoning, China
General Hospital of Ningxia Medical University
NOT_YET_RECRUITING

Yinchuan, Ningxia, China
General Hospital of Northern Theater Command
RECRUITING

Shenyang, Liaoning, 110016, China
Guang'an People's Hospital
NOT_YET_RECRUITING

Guang’an, Sichuan, China
Guang'anmen Hospital,China Academy of Chinese Medical Sciences
NOT_YET_RECRUITING

Beijing, Beijing Municipality, China
Handan Central Hospital
NOT_YET_RECRUITING

Handan, Hebei, China
HeGang People's Hospital
NOT_YET_RECRUITING

Hegang, Heilongjiang, China
Hebei General Hospital
NOT_YET_RECRUITING

Shijiazhuang, Hebei, China
Hunan Provincial TCM Hospital
NOT_YET_RECRUITING

Changsha, Hunan, China
Huzhou Central Hospital
NOT_YET_RECRUITING

Huzhou, Zhejiang, China
Jiangsu Provincial People's Hospital Suqian Branch
NOT_YET_RECRUITING

Suqian, Jiangsu, China
Jilin People's Hospital
NOT_YET_RECRUITING

Jilin City, Jilin, China
Jilin Provincial People's Hospital
NOT_YET_RECRUITING

Changchun, Jilin, China
Jingjiang People's Hospital
NOT_YET_RECRUITING

Cangzhou, Hebei, China
Liuzhou People's Hospital
NOT_YET_RECRUITING

Liuzhou, Guangxi, China
Mudanjiang Cardiovascular Disease Hospital
NOT_YET_RECRUITING

Mudanjiang, Heilongjiang, China
Nanjing Lishui People's Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, China
Ningbo Medical Center Lihuili Hospital
NOT_YET_RECRUITING

Ningbo, Zhejiang, China
PLA Joint Logistics Support Force No.970 Hospital
NOT_YET_RECRUITING

Yantai, Shandong, China
Qilu Hospital of Shandong University
NOT_YET_RECRUITING

Jinan, Shandong, China
Ruijin Hospital Luban Branch, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Shandong University of Traditional Chinese Medicine Affiliated Hospital
NOT_YET_RECRUITING

Jinan, Shandong, China
Shanghai Tenth People's Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITING

Shaoxing, Zhejiang, China
Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Taizhou Central Hospital
NOT_YET_RECRUITING

Taizhou, Zhejiang, China
Taizhou Fourth People's Hospital
NOT_YET_RECRUITING

Taizhou, Jiangsu, China
Taizhou Hospital of Zhejiang Province
NOT_YET_RECRUITING

Taizhou, Zhejiang, China
Tengzhou Central People's Hospital
NOT_YET_RECRUITING

Tengzhou, Shandong, China
The 7th People's Hospital of Zhengzhou
NOT_YET_RECRUITING

Zhengzhou, Henan, China
The 960th Hospital of the PLA Joint Logistics Support Force
NOT_YET_RECRUITING

Jinan, Shandong, China
The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITING

Qingdao, Shandong, China
The Affiliated People'sHospital of Ningbo University
NOT_YET_RECRUITING

Ningbo, Zhejiang, China
The Eighth Affiliated Hospital,Sun Yat-sen University
NOT_YET_RECRUITING

Shenzhen, Shenzhen, China
The Fifth Affiliated Hospital,Sun Yat-sen University
NOT_YET_RECRUITING

Zhuhai, Guangdong, China
The First Affiliated Hospital of Dalian Medical University
NOT_YET_RECRUITING

Dalian, Liaoning, China
The First Affiliated Hospital of Guangxi Medical University
NOT_YET_RECRUITING

Nanning, Guangxi, China
The First Affiliated Hospital of Guilin Medical University
NOT_YET_RECRUITING

Guilin, Guangxi, China
The First Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITING

Guiyang, Guizhou, China
The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Haerbin, Heilongjiang, China
The First Affiliated Hospital of Hebei North University
NOT_YET_RECRUITING

Zhangjiakou, Hebei, China
The First Affiliated Hospital of Zunyi Medical University"
NOT_YET_RECRUITING

Zunyi, Guizhou, China
The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
The First Bethune Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, China
The First Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, China
The First Hospital of Jiaxing
NOT_YET_RECRUITING

Jiaxing, Zhejiang, China
The First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, China
The Fourth Affiliated Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, China
The Fourth People's Hospital of Jinan
NOT_YET_RECRUITING

Jinan, Shandong, China
The People's Hospital of Bozhou
NOT_YET_RECRUITING

Haozhou, Anhui, China
The People's Hospital of Guangxi Zhuang Autonomous Region
NOT_YET_RECRUITING

Nanning, Guangxi, China
The People's Hospital of Jianyang City
NOT_YET_RECRUITING

Jiancheng, Sichuan, China
The Second Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Haerbin, Heilongjiang, China
The Second Affiliated Hospital of Shantou University Medical College
NOT_YET_RECRUITING

Shantou, Guangdong, China
The Second Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITING

Xi’an, Shanxi, China
The Second Hospital of Jiaxing
NOT_YET_RECRUITING

Jiaxing, Zhejiang, China
The Second Hospital of Tianjin Medical University
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, China
The Second Norman Bethune Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, China
The Second People's Hospital of Liaocheng
NOT_YET_RECRUITING

Liaocheng, Shandong, China
The Southwest Hospital of Amu
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
The Third People's Hospital of Zhengzhou
NOT_YET_RECRUITING

Zhengzhou, Henan, China
The affiliated traditional Chinese medicine hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
The first affiliated hospital, Sun Yat-sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
Tianjin Chest Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, China
Tianjin Fifth Center Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, China
Tianjin Hospital of Integrated Traditional Chinese and Western Medicine
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, China
Xi'an Gaoling District Hospital
NOT_YET_RECRUITING

Xi’an, Shanxi, China
Xingtai People's Hospital
NOT_YET_RECRUITING

Xingtai, Hebei, China
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Xuyi People's Hospital
NOT_YET_RECRUITING

Huai'an, Jiangsu, China
Xuzhou No.1 People's Hospital
NOT_YET_RECRUITING

Xuzhou, Jiangsu, China
Yantai Affiliated Hospital of Binzhou Medical University
NOT_YET_RECRUITING

Yantai, Shandong, China
Yantai Yuhuangding Hospital
NOT_YET_RECRUITING

Yantai, China
Yiyang Central Hospital
NOT_YET_RECRUITING

Yiyang, Hunan, China
Yunnan Provincial Hospital of Traditional Chinese Medicine
NOT_YET_RECRUITING

Kunming, Yunnan, China
Zhejiang Provincial People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Zhongda Hospital Southeast University
NOT_YET_RECRUITING

Nanjing, Jiangsu, China

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