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Spine surgery showdown: which approach helps patients recover faster?

NCT ID NCT01024699

Symptom relief Sponsor: NuVasive Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two types of spine surgery (XLIF and TLIF) in 55 adults with a slipped vertebra causing pain and leg symptoms. The goal was to see which procedure led to better function and less pain over two years. Results could help doctors choose the best surgical approach for each patient.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical procedure (XLIF or TLIF)
What this could lead to
If one procedure proves better, it could help surgeons choose the less painful or more effective option for patients with slipped vertebrae.
What could go wrong
This is a small, completed study with only 55 participants, so results may not apply to everyone. Surgery always carries risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

55 people

The number who actually took part.

Start date

Nov 2009

Finished

Feb 2015

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study population will consist of patients from participating site locations.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Male and female patients who are at least 18 years of age; \- Patients who present with symptomatic Grade I or II degenerative spondylolisthesis at 1 or 2 contiguous lumbar levels between L1 and L5 and are surgical candidates for interbody lumbar fusion surgery; symptoms should include radiculopathy and/or neurogenic claudication with or without back pain; \- Patients who have been unresponsive to at least 6 months of conservative treatments or exhibit progressive neurological symptoms in the face of conservative treatment; \- Patients who understand the conditions of enrollment and are willing to sign an informed consent to participate in the study. Exclusion Criteria: \- Patients with lumbar pathologies requiring treatment at more than 2 levels; \- Patients who have had previous lumbar fusion surgery; \- Patients with lytic spondylolisthesis or a defect of the pars interarticularis; \- Patients with radiographic confirmation of Grade IV facet joint disease or degeneration; \- Patients with non-contained or extruded herniated nucleus pulposus

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Conditions

The condition(s) this trial relates to.

spondylolisthesis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spondylolisthesis

Contacts and locations

Locations

  • Celebration Florida Hospital

    Kissimmee, Florida, 34747, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Northwest Orthopaedic Specialists, P.S.

    Paducah, Kentucky, 42003, United States

  • Northwest Orthopaedic Specialists, P.S.

    Spokane, Washington, 99208, United States

  • Orthopaedic Clinic-Riverside Campus, University of Minnesota

    Minneapolis, Minnesota, 55454, United States

  • Spine and Sports Institute

    Richland, Washington, 99352, United States

  • St. Joseph's/Candler Health System

    Savannah, Georgia, 31405, United States

  • St. Vincent-Jacksonville

    Jacksonville, Florida, 32204, United States

  • The Methodist Hospital

    Houston, Texas, 77030, United States

More trials for these conditions

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