Cream wraps could soothe painful skin for ichthyosis patients
NCT ID NCT05979506
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a series of three cream wraps can reduce skin discomfort in people with moderate to very severe hereditary ichthyosis. Participants will receive a therapeutic bath followed by application of a rich emollient cream and a plastic wrap for one hour. The main goal is to see if at least a 3-point reduction in skin discomfort is achieved 11 days after treatment. The study enrolls 34 people and is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- emollient cream and urea cream applied under occlusion (wraps)
- What this could lead to
- If it works, this could offer a simple, nurse-led way to ease painful skin discomfort for people with ichthyosis.
- What could go wrong
- This is a small, early study (34 people) with no control group, so results may not apply to everyone. The benefit may be short-lived or no better than standard creams.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 34 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2024
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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15 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with hereditary ichthyosis regardless of the clinical form * Patient with a scaling or erythema score \> 6/16 * Patient with a skin discomfort score \> 3/10 * Patient having given written, free and informed consent * Patient affiliated to a social security scheme Exclusion Criteria: * Patient with a skin disease other than ichthyosis * Patient having modified his treatments for ichthyosis in the month preceding inclusion * Patient with known intolerance or allergy to one of the topicals used in the study * Patient unable to complete the study questionnaires * Patient under a protection regime
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Toulouse University hospital
RECRUITINGToulouse, 31059, France
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