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Tiny blood sample, big clues: stem cell study aims to unlock williams syndrome brain mystery

NCT ID NCT07537374

Knowledge-focused Sponsor: Qilu Hospital of Shandong University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will collect blood from 3 children with Williams syndrome and 3 healthy children. Scientists will turn blood cells into stem cells and then into brain cells to study how the brain develops differently in Williams syndrome. The goal is to understand the disease better, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal how brain cells develop differently in Williams syndrome, pointing toward future targets for therapies.
What could go wrong
This is a very small, early-stage observational study with only 6 participants, so findings may not apply broadly. It is not testing any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 6 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The subjects of this study were children with Williams syndrome who were treated or followed up at Qilu Hospital of Shandong University, as well as healthy children recruited from the pediatric outpatient department during the same period. The study intends to collect peripheral blood samples from these children as subjects, establish a source-derived induced pluripotent stem cell (iPSC) line for the subjects, and use it for subsequent in vitro differentiation and mechanism research. It is planned to include 3 children with Williams syndrome and 3 healthy children, all of whom are independent donor-derived samples.

Ages

3 to 12 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The clinical diagnosis is Williams syndrome. 2. Child subjects; 3. The guardian signs the informed consent form. If necessary, the subject himself/herself signs the informed consent or the informed consent with additional consent. 4. Be capable of completing peripheral blood collection; Exclusion Criteria: 1. Cases of severe infection, severe hematological diseases or other conditions that make blood collection inappropriate; 2. Recent receipt of special treatments that may significantly affect the state of peripheral blood cells; 3. Insufficient sample volume or poor sample quality that does not meet the requirements for reprogramming experiments; 4. Guardians' refusal to allow the samples to be used for iPSC establishment and subsequent research; 5. Other circumstances judged by the researchers as not suitable for inclusion in this study.

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Conditions

The condition(s) this trial relates to.

Williams syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Induced pluripotent stem cell (ips cell) Williams syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.