Diet sheds light on iron deficiency in obesity
NCT ID NCT06104800
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how weight loss from a calorie-restricted diet affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, along with iron levels before and after a 60-day diet. The goal was to understand the link between obesity-related inflammation and poor iron status. 42 adults completed the study, comparing two high-protein diets (with or without red meat).
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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42 people
The number who actually took part.
- Started
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Jan 2024
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Phase 1 * Signing of the informed consent form * Both sexes * Adults over 18 years of age * BMI of 18.5 and under 40 kg/m2 Phase 2 * Both sexes * Adults older than 18 years * People with obesity (BMI of 30 to 40 kg/m2) and serum iron \< 50 micrograms/dL. * Total cholesterol less than 240 mg/dL (with the diet plan 20% decrease). Exclusion Criteria: * Any type of diabetes. * Patients with renal disease diagnosed by a physician. * Patients with acquired diseases that secondarily produce obesity and diabetes. * Patients who have suffered a cardiovascular event. * Weight loss \> 3 kg in the last 3 months. * Patients with catabolic diseases such as cancer and acquired immunodeficiency syndrome. * Pregnancy. * Treatment with any drug treatment: 1. Treatment with antihypertensive drugs (loop or potassium-sparing diuretics, angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin II receptor blockers, alpha blockers, calcium antagonists, beta blockers). 2. Treatment with hypoglycemic agents (sulfonylureas, biguanides, incretins) or insulin and antidiabetics. 3. Treatment with statins, fibrates or other drugs to control dyslipidemia. 4. Use of steroid drugs, chemotherapy, immunosuppressants or radiotherapy. 5. Anorectics or drugs that accelerate weight loss. 6. Any drug or medication that activates intestinal motility (cisapride, dimethicone, domperidone, metoclopramide, trimebutine). 7. Laxatives or antispasmodics 4 weeks prior to the study h) Antibiotic treatment 2 months prior to the study. * Patients who have suffered a blood loss of more than 500 ml or recent gastrointestinal tract perforation. * Patients with a smoking index greater than 21. * Consumption of large amounts of alcohol (14 drinks for women or 21 drinks for men in a normal week). * Consumption of any recreational psychoactive substance. * Treatment with any medication that influences inflammation or iron metabolism (proton pump inhibitors, antacids, bisphosphonates, bile acid or calcium sequestrants). * Patients who are vegetarians * Allergy or intolerance to any food mentioned in the proposed pantry such as egg, dairy, fish, tuna, chicken, beans, lima beans and/or lentils. * Unwillingness to consume any of the foods listed in the proposed pantry.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
México, Mexico
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