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Wegovy under the microscope: Real-World obesity study tracks safety and weight loss

NCT ID NCT06283667

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows over 1,000 people with obesity in Japan who are taking Wegovy as prescribed by their doctor. Researchers will track side effects and weight changes for about 2 years to see how the drug works in everyday life, not just in a lab. The goal is to better understand the real-world safety and effectiveness of this weight-loss medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,071 people

The number who actually took part.

Started

Jun 2024

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants are patients with obesity treated with Wegovy® (semaglutide) once weekly under real-world clinical practice conditions in Japan.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol) * The decision to initiate treatment with commercially available Wegovy® has been made by the patient/Legally Acceptable Representative (LAR) and the treating physician before and independently from the decision to include the patient in this study * Male or female, no age limitation * Diagnosis of obesity disease; with either hypertension, dyslipidaemia or type 2 diabetes, insufficiently controlled with diet and exercise therapies, and should meet either of: 1. Body mass index (BMI)\* greater than or equal to 27 kilograms per meter square (kg/m\^2) with two or more obesity-related comorbidities\*\*, or 2. BMI\* greater than or equal to 35 kg/m\^2 * Participant who has never been exposed to Semaglutide or who started treatment with Wegovy® within the past 4 weeks at registration * BMI calculation will be based on height and body weight recorded in the enrolment form of electronic case report form (eCRF) at enrolment. * Definition of obesity-related comorbidities are in accordance with Japan Student Services Organization (JASSO) guideline 3: (1) impaired glucose tolerance, (2) dyslipidaemia, (3) hypertension, (4) hyper-uricemia/gout, (5) coronary artery disease, (6) cerebral infarction, (7) non-alcoholic fatty liver disease, (8) menstrual disorder/infertility, (9) obstructive sleep apnoea syndrome/obesity-hypoventilation syndrome, (10) locomotory disease or (11) obesity-related kidney disease. Exclusion Criteria: * Previous participation in this study. Participation is defined as having given informed consent in this study * Treatment with any investigational drug within 30 days prior to baseline (Visit 1) * Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation * A history of hypersensitivity to any ingredients of this drug * Diabetic ketoacidosis, diabetic coma, pre-coma or type 1 diabetes mellitus \[The treatment with insulin is mandatory. It is not appropriate to use this drug\] * In emergency cases such as severe infections and surgery in patients with type 2 diabetes \[It is desirable to control blood glucose with insulin; therefore, administration of this drug is not appropriate\] * Pregnant or possibly pregnant female * Female who plans to become pregnant within 2 months

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • Aichi Medical University Hospital_Diabetes Medicine

    Nagakute-shi, Aichi, 480-1195, Japan

  • Akita University Hospital, Diabetes and Endocrinology

    Akita-shi, Akita, 010-8543, Japan

  • Aso Clinic

    Shizuoka, 410-0041, Japan

  • Bellland Sogo Byoin_Endocrinology and Metabolism

    Osaka, 599-8247, Japan

  • Chiba University Hospital_Diabetes, Metabolism and Endocrinology

    Chiyoda-ku, Tokyo, 100-0005, Japan

  • Chibune Hospital_Diabetes and Endocrinology

    Osaka, 555-0034, Japan

  • Chuno Kosei Hospital_Endocrinology and Diabetes

    Gifu, 501-3802, Japan

  • Chutoen General Medical Center_Diabetes and Endocrinology

    Shizuoka, 436-8555, Japan

  • Fujita Health University Hospital_Endocrinology, Diabetes and Metabolism

    Aichi, 470-11-1, Japan

  • Fukuoka Kieikai Hospital_Diabetes and obesity centre

    Fukuoka, 813-0044, Japan

  • Fukuoka Sanno Hospital_Diabetology and Endocrinology and Metabolism

    Fukuoka, 814-0001, Japan

  • Fukuoka University Chikushi Hospital_Endocrinology and Diabetes Mellitus

    Chikushino-shi, Fukuoka, 818-8502, Japan

  • Fukushima Medical University Hospital_Diabetes and Endocrinology

    Fukushima, 960-1295, Japan

  • Gifu University Hospital_The Third Dept. of Internal Medicine

    Tokyo, 100-0005, Japan

  • Gunma University Hospital_Endocrinology and Diabetes

    Gunma, 371-8511, Japan

  • Hachinohe City Hospital_Diabetes and Metabolism

    Aomori, 031-8555, Japan

  • Hamamatsu Medical Center_Endocrinology and Metabolism

    Shizuoka, 432-8580, Japan

  • Hamamatsu University Hospital_Liver Internal Medicine

    Hamamatsu-shi, Shizuoka, 431-3192, Japan

  • Hyogo Medical University Hospital_Diabetes, Endocrinology and Metabolism

    Hyōgo, 663-8131, Japan

  • Ichinomiyanishi Hospital

    Aichi, 494-0001, Japan

  • Institute of Science Tokyo Hospital_Cardiology

    Tokyo, 113-8519, Japan

  • Iwate Medical University Uchimaru Medical Center, Division of Diabetes and Metabolism and Endocrine medicine

    Numakunai, 020-8505, Japan

  • JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine

    Shizuoka, 430-0929, Japan

  • Japanese Red Cross Asahikawa Hospital_Diabetes and Endocrinology

    Hokkaido, 070-8530, Japan

  • Japanese Red Cross Hamamatsu Hospital_Cardiology

    Shizuoka, 434-8533, Japan

  • Japanese Red Cross Ise Hospital_Diabetes and Metabolism

    Mie, 516-8512, Japan

  • Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology

    Wakayama, 640-8558, Japan

  • Jinnouchi Hospital_Internal Medicine

    Kumamoto, Kumamoto, Japan, 862-0976, Japan

  • Juntendo University Hospital_Tokyo

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Juntendo University Shizuoka Hospital_Diabetes and Endocrinology

    Shizuoka, 410-2295, Japan

  • Kagoshima University Hospital_Diabetes and Endocrinology

    Kagoshima, 890-8520, Japan

  • Kameda Medical Center_Diabetes and Endocrinology

    Chiba, 296-8602, Japan

  • Kanto Rousai Hospital_Diabetes and Endocrinology

    Kanagawa, 211-8510, Japan

  • Karatsu Redcross Hospital_Diabetes Internal Medicine

    Saga, 847-8588, Japan

  • Kasugai Municipal Hospital_Cardiovascular Medicine

    Kasugai-shi, Aichi, 486-8510, Japan

  • Kawasaki Municipal Hospital_Diabetes and Endocrinology

    Kanagawa, 210-0013, Japan

  • Keio University Hospital_Neurology

    Tokyo, 160-8582, Japan

  • Kimitsu Chuo Hospital_Diabetology and Endocrinology

    Chiba, 292-0822, Japan

  • Kishiwada City Hospital_Endocrinology and Metabolism

    Osaka, 596-8501, Japan

  • Kochi Medical School Hospital_Endocrinology, Metabolism and Nephrology

    Kochi, 783-8505, Japan

  • Kumamoto General Hospital_Diabetes Center

    Kumamoto, 866-8660, Japan

  • Kumamoto University Hospital, Diabetes, Metabo and Endo

    Kumamoto-shi, Kumamoto, 860-0811, Japan

  • Kure Medical Center and Chugoku Cancer Center

    Kure-shi, Hiroshima, 737-0023, Japan

  • Kyorin University Hospital_Diabetes and Endocrinology

    Tokyo, 181-8611, Japan

  • Kyoto City Hospital_Diabetes and Metabolism

    Kyoto, 604-8845, Japan

  • Kyoto University Hospital_Department of Diabetes, Endocr

    Kyoto-shi, Kyoto, 606-8507, Japan

  • Kyushu University Hospital_Endocrine Metab Diab inter med

    Fukuoka-shi, Fukuoka, 812-8582, Japan

  • Matsunami General Hospital_Diabetes and Endocrinology

    Gifu, 501-6062, Japan

  • Matsushita Memorial Hospital_Diabetes and Endocrinology

    Osaka, 570-8540, Japan

  • Matsuyama Shimin Hospital_Diabetes and Endocrinology

    Ehime, 790-0067, Japan

  • Mazda Hospital_Diabetes

    Hiroshima, 735-8585, Japan

  • Mie University Hospital_Diabetes and Endocrinology

    Mie, 514-8507, Japan

  • Mikannohana Clinic

    Ehime, 790-0034, Japan

  • Minamata City General Hospital & Medical Center_Metabolism

    Kumamoto, 867-0041, Japan

  • Miura Central Clinic

    Miura-shi, Kanagawa, 238-0101, Japan

  • Murakami Memorial Hospital_Diabetes Internal Medicine

    Hiroshima, 722-0014, Japan

  • NTT East Japan Sapporo HP_Diabetes Mellitus & Int med Endo

    Sapporo, Hokkaido, 060-8648, Japan

  • Nagano Matsushiro General Hospital_department of diet

    Nagano, 381-1231, Japan

  • Nagasaki Hospital_Internal Medicine

    Tochigi, 326-0053, Japan

  • Nagoya City University Hospital_Obesity Treatment Center

    Aichi, 467-8602, Japan

  • Nakadori General Hospital_Diabetes and Endocrinology

    Akita, 010-8577, Japan

  • National Center for Child Health and Development_Internal medicine for women

    Tokyo, 157-8535, Japan

  • National Hospital Organization Fukuokahigashi Medical Center_Diabetes and Endocrinology

    Fukuoka, 811-3195, Japan

  • National Hospital Organization Kyoto Medical Center_Cardiology

    Kyoto-shi, Kyoto, 612-8555, Japan

  • Nihon University Hospital_Internal Medicine

    Tokyo, 101-8309, Japan

  • Nihonbashi Leiwa Naika Clinic

    Tokyo, 103-0027, Japan

  • Nippon Medical School Musashikosugi Hospital_Neurological Surgery

    Kawasaki-shi, Kanagawa-ken, 211-0063, Japan

  • Novo Nordisk Investigational Site

    Tokyo, Chiyoda City, 100-0005, Japan

  • Odate Municipal General Hospital_Endocrinology and Metabolism

    Akita, 017-8550, Japan

  • Ogaki Municipal Hospital_Diabetes and Nephrology

    Gifu, 503-8502, Japan

  • Okayama Medical Center_Cardiology

    Okayama-shi, Okayama, 701-1192, Japan

  • Okayama Rosai Hospital_Cardiology

    Okayama, 702-8055, Japan

  • Okayama University Hospital_Neph. and Diabetes, Metabolism

    Okayama, 700-0914, Japan

  • Okazaki City Hospital

    Aichi, 444-8553, Japan

  • Osaka City General Hospital_Endocrinology and Diabetes Mellitus

    Osaka-shi, Osaka, 534-0021, Japan

  • Osaka Metropolitan University Hospital_Lifestyle disease diabetes centre

    Osaka, 545-0051, Japan

  • Osaka National Hospital_Diabetes Internal Medicine

    Osaka, 540-0006, Japan

  • Osaki citizen hospital_Diabetes and metabolic disease

    Osaki-shi, Miyagi, 989-6183, Japan

  • Sano Kosei General Hospital_Neph.& Endocrinology,Metab.

    Tochigi, 327-8511, Japan

  • Sapporo Medical University Hospital_Cardiovascular, Kidney, Metabolism Endocrinology

    Sapporo-shi, Hokkaido, 060-8543, Japan

  • Sapporo Tonyobyo Kojosen Clinic

    Hokkaido, 060-0807, Japan

  • Shimane Univ. HP, Dept of Endocrinology&Metabolism

    Izumo, Shimane, 691-8501, Japan

  • Shimonoseki Medical Center_Diabetes and Endocrinology

    Yamaguchi, 750-0061, Japan

  • Shin Koga Hospital

    Kurume-shi, Fukuoka, 830 8577, Japan

  • Shinbeppu Hospital_Endocrinology and Metabolism

    Ōita, 874-8538, Japan

  • Shinmatsudo Central General Hospital_Diabetes and Endocrinology

    Chiba, 270-0034, Japan

  • Showa University Fujigaoka Hospital_Internal Medicine

    Kanagawa, 227-8501, Japan

  • St. Marianna University School of Medicine Hospital

    Kanagawa, 216-0015, Japan

  • Tamaki Aozora Byoin_Diabetes and Endocrinology

    Tokushima, 779-3125, Japan

  • The Jikei University Hospital Dept of Diabetes, Metabolic

    Tokyo, 105-8471, Japan

  • Toho University Sakura Medical Center

    Chiba, 285-8741, Japan

  • Tokai University Hospital_Nephrology, Endocrinology and Metabolism

    Kanagawa, 259-1193, Japan

  • Tokyo Medical Univ. Hospital_Diabetes, Metabolism and Endocrinology

  • Tokyo Metropolitan Tama Medical Center

    Tokyo, 183-8524, Japan

  • Tokyo Teishin Hospital

    Tokyo, 102-8798, Japan

  • Tokyo Women's Medical University_Diabetes and Metabolism

    Tokyo, 162-0054, Japan

  • Tottori University Hospital_Endocrinology and Metabolism

    Tottori, 683-8504, Japan

  • Tottori University Hospital_Pharmacotherapy

    Tottori, 683-8504, Japan

  • Toyohashi Municipal Hospital

    Toyohashi-shi, Aichi-ken, 441-8085, Japan

  • University Hospital Kyoto Prefectual University of Medicine

    Kyoto, 602-8566, Japan

  • University of Fukui Hospital

    Fukui, 910-1193, Japan

  • University of Tsukuba Hospital_Diabetes and Endocrinology

    Ibaraki, 305-8576, Japan

  • University of the Ryukyus Hospital

    Nakagami-gun, Okinawa-ken, 903-0125, Japan

  • Urasoe General Hospital_Cardiology

    Okinawa, 901-2102, Japan

  • Wakayama Medical Univercity Hospital_Diabetes and Endocrinology

    Wakayama, 641-8510, Japan

  • Yamagata University Hospital, Internal Medicine 3

    Yamagata-shi, Yamagata, 990-9585, Japan

  • Yamaguchi Rosai Hospital_Diabetes and Endocrinology

    Yamaguchi, 756-0095, Japan

  • Yokohama City Minato Red Cross Hospital_Endocrinology

    Kanagawa, 231-8682, Japan

  • Yokohama City University Hospital_Endocrinology, Metabolism

    Yokohama, Kanagawa, 236-0004, Japan

  • Yokohama City University Medical Center_Endocrinology and Diabetes

    Kanagawa, 232-0024, Japan

  • Yokohama City University Medical Center_Nephrology and Hypertension

    Kanahawa, 232-0024, Japan

  • Yokohama Rosai Hospital_Diabetes and Endocrinology

    Kanagawa, 222-0036, Japan

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