New breathing trial strategy may cut ventilator time for ICU patients
NCT ID NCT03861117
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two ways of helping critically ill patients who are having trouble coming off a breathing machine (ventilator). One method used a T-piece (a simple tube), while the other used a machine that gives extra pressure support. The goal was to see which approach helps patients breathe on their own sooner and avoid needing the ventilator again. The trial involved 98 adults in intensive care who had already failed one weaning attempt.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to shorter time on breathing machines for ICU patients, reducing complications and speeding recovery.
- What could go wrong
- This is a small, completed study (98 patients) comparing two procedures, not a new drug or therapy. Results may not apply to all ICU patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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98 people
The number who actually took part.
- Started
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May 2019
- Finished
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Jun 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient 18 years old or more * Intubated and ventilated in intensive care unit for more than 24 hours * Patient ready for weaning evaluation * Failure of a first T-piece SBT Exclusion Criteria: * Chronic neuromuscular disease * Guillain-Barré Syndrome * Central nervous system disease with consciousness disorder * Tracheostomy * Chronic disease with life expectancy less than 1 year * Pregnancy, breast feeding * Withholding life support regarding a reintubation * Prisoner or patient interned in psychiatric hospital * Guardianship * Language barrier * Lack of medical insurance * Lack of the patient's consent (or of the next of kin where appropriate) * Patient under an exclusion period after enrollment in another research study
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital de la Croix-Rousse
Lyon, 69317, France