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New method may shorten need for blood pressure drug after heart surgery

NCT ID NCT02479529

Disease control Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new way to decide when to stop the blood pressure drug norepinephrine in patients who had heart surgery and developed dangerously low blood pressure. The method uses a measure called dynamic arterial compliance to guide the drug reduction. The trial involved 130 adults and compared this approach to standard care. The goal was to see if it could reduce the time patients need the drug.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine
What this could lead to
If successful, this approach could help doctors safely reduce vasopressor use faster after heart surgery, potentially shortening ICU stays.
What could go wrong
This is a single-center trial with 130 patients, so results may not apply broadly. The method may not improve outcomes in all settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

130 people

The number who actually took part.

Start date

Oct 2014

Finished

Jun 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Major patient ≥ 18 years * Patient operated a cardiac surgery for myocardial revascularization (CABG surgery) or surgical correction of valvular or combined surgery (CABG and valve disease) or surgery the ascending aorta and cardiac surgery with vasoplegic syndrome treated by norepinephrine * Signed consent * Affiliation to social assurance Exclusion Criteria: * Permanent atrial fibrillation * Treatment with dobutamine and/or epinephrine * Pregnant woman * Patient under guardianship or private public law * Internal pacemaker * Hypothermia * Patient refusal

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Conditions

The condition(s) this trial relates to.

Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vasoplegic syndrome

Contacts and locations

Locations

  • CHU Amiens-Picardie

    Amiens, Picardie, 80054, France

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