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Walking workouts may sharpen the MS brain — a trial puts it to the test

NCT ID NCT05755061

Disease control Sponsor: Kessler Foundation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether a 12-month aerobic walking program can improve cognitive processing speed and brain connectivity in adults with multiple sclerosis who have slowed thinking. Participants will be randomly assigned to one of two home-based walking programs that differ in intensity and frequency, with progress tracked via Fitbit. Researchers will measure changes in thinking speed, brain scans, and walking function at the start, middle, and end of the year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aerobic walking exercise programs (GEMS Plus and GEMS)
What this could lead to
If successful, this could establish a practical, home-based exercise prescription to help preserve or improve cognitive function and brain connectivity in people with MS.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not apply broadly. The benefits of exercise on cognition may be modest, and adherence to a year-long program can be challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

31 people

The number who actually took part.

Started

Feb 2023

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Definite MS diagnosis * Relapse-free for at least 30 days * Have Internet access on a device larger than a smartphone * Willingness and ability to travel to Kessler Foundation 3 times over a 12-month period * Be insufficiently physically active * Demonstrate low fall risk based on Activities Specific Balance Confidence scores * Demonstrate low contraindications for exercise * Right handedness * English as a primary language * Demonstrate low cognitive processing speed based on a Zoom-administered Symbol Digit Modalities Test Exclusion Criteria: * Acutely taken corticosteroids within 30 days of enrollment * Use an assistive device (i.e., cane, crutch, walker, rollator) for ambulation * Experienced a fall in the past 6 months * Have uncontrolled major depressive disorder or history of bipolar disorder or schizophrenia * Regularly taking medications that can affect cognition (e.g., antipsychotics, benzodiazepines) * Demonstrate contraindications for 3T MRI (i.e., having metal/shrapnel in the body, non-MRI compatible aneurysm clips) * Have severe cognitive impairment causing an inability to follow directions

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Conditions

The condition(s) this trial relates to.

Motor Activity multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis Relapsing-remitting multiple sclerosis

Contacts and locations

Locations

  • Kessler Foundation

    West Orange, New Jersey, 07052, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.