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Experimental drug aims to treat dangerous blood reaction to common blood thinner

NCT ID NCT05785819

First seen Jan 06, 2026 · Last updated May 26, 2026 · Updated 24 times

Summary

This study tested an experimental drug called VLX-1005 in people with a rare condition called heparin-induced thrombocytopenia (HIT), where a common blood thinner causes low platelets and dangerous blood clots. About 24 adults with suspected HIT received either VLX-1005 or a placebo, along with standard care. The trial was stopped early, so results are limited, but researchers were looking at how quickly platelet levels recovered and whether serious complications like stroke or clots occurred.

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Contacts and locations

Locations

  • Carilion Medical Center

    Roanoke, Virginia, 24014, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Georgetown University

    Washington D.C., District of Columbia, 20007, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Stanford University

    Stanford, California, 94305, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Washington

    Seattle, Washington, 98195, United States

  • Universiy of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Versiti at Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Yale University

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.