Could vitamin d boost fertility? new study investigates
NCT ID NCT05050916
First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 9 times
Summary
This completed Phase 2 trial looked at whether vitamin D supplements affect hormones linked to healthy menstrual cycles. Nearly 1,000 women aged 19-40 with natural cycles took either high-dose vitamin D (50,000 IU/week) or a placebo for about 3 months. Researchers measured hormone levels in urine and blood to see if vitamin D improves ovulation and fertility indicators.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin D (cholecalciferol)
- What this could lead to
- If it works, this could show that vitamin D helps regulate menstrual cycles, potentially improving fertility understanding.
- What could go wrong
- This is a completed Phase 2 trial, so results are preliminary. The study is observational in nature and does not test a treatment for infertility directly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
998 people
The number who actually took part.
- Started
-
Mar 2023
- Finished
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Jun 2024
- Lead sponsor
-
A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
19 to 40 years
- Sex
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Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Having natural, spontaneous menstrual cycles (no hormonal therapy) less than 50 days in length. * Aged 19-40 years * Ability to take a vitamin D capsule and willing to adhere to the weekly regimen * If sexually active, use of a non-hormonal contraceptive method. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * No menstrual period in the last 50 days, or, a typical menstrual cycle length \<16 or \>49 days. * Use of a vitamin D supplement for more than one month and on more than 15 days out of each month. Volunteers will be asked to check their supplement label for vitamin D content. * Unwilling to abstain from taking non-study vitamin D supplements during the study or if already taking a medically-advised vitamin D supplement. * Use of a calcium supplement (including certain antacids) and unwilling to abstain from taking a calcium supplement during the study. * Known polycystic ovarian syndrome * Depo-provera use in the previous 12 months * Current use of any hormones, including birth control * Current use of a hormonal intrauterine device (IUD) * Current pregnancy or lactation, trying to become pregnant, or planning to try in the next four menstrual cycles or 5 months. * History of seizure disorders * Celiac disease * Crohn s Disease * Body mass index \>35 * Aged \<19 or \> 40 years * Presence of known contraindications for vitamin D supplementation, history of any of the following: calcium disorder or hypercalcemia, tuberculosis or granulomatous disease, metastatic bone disease, sarcoidosis, Williams syndrome, kidney disease (kidney stones, renal failure or dialysis, lupus nephritis) * Known liver disease (cirrhosis) * History of cancer other than skin cancer. * History of anorexia nervosa, bulimia or an eating disorder * Use within the past 60 days, of exogenous hormones * Type 1 or Type 2 diabetes * Known heart disease * Gastric bypass surgery * Unwilling or unable to complete study activities, e.g. collect daily urine specimens, have blood drawn, complete daily diaries, attend in person study visits 25\. Non-English speaking * Due to the complexity of daily/weekly diaries, testing and procedurerequirements, all consents, instructions and questionnaires are provided in English. Therefore, all participants must be able to able to read and speak English.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Henry Ford Health System
Detroit, Michigan, 48187, United States
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NIEHS Clinical Research Unit (CRU)
Research Triangle Park, North Carolina, 27709, United States
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