Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Could vitamin d boost fertility? new study investigates

NCT ID NCT05050916

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 9 times

Summary

This completed Phase 2 trial looked at whether vitamin D supplements affect hormones linked to healthy menstrual cycles. Nearly 1,000 women aged 19-40 with natural cycles took either high-dose vitamin D (50,000 IU/week) or a placebo for about 3 months. Researchers measured hormone levels in urine and blood to see if vitamin D improves ovulation and fertility indicators.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin D (cholecalciferol)
What this could lead to
If it works, this could show that vitamin D helps regulate menstrual cycles, potentially improving fertility understanding.
What could go wrong
This is a completed Phase 2 trial, so results are preliminary. The study is observational in nature and does not test a treatment for infertility directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

998 people

The number who actually took part.

Started

Mar 2023

Finished

Jun 2024

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Having natural, spontaneous menstrual cycles (no hormonal therapy) less than 50 days in length. * Aged 19-40 years * Ability to take a vitamin D capsule and willing to adhere to the weekly regimen * If sexually active, use of a non-hormonal contraceptive method. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * No menstrual period in the last 50 days, or, a typical menstrual cycle length \<16 or \>49 days. * Use of a vitamin D supplement for more than one month and on more than 15 days out of each month. Volunteers will be asked to check their supplement label for vitamin D content. * Unwilling to abstain from taking non-study vitamin D supplements during the study or if already taking a medically-advised vitamin D supplement. * Use of a calcium supplement (including certain antacids) and unwilling to abstain from taking a calcium supplement during the study. * Known polycystic ovarian syndrome * Depo-provera use in the previous 12 months * Current use of any hormones, including birth control * Current use of a hormonal intrauterine device (IUD) * Current pregnancy or lactation, trying to become pregnant, or planning to try in the next four menstrual cycles or 5 months. * History of seizure disorders * Celiac disease * Crohn s Disease * Body mass index \>35 * Aged \<19 or \> 40 years * Presence of known contraindications for vitamin D supplementation, history of any of the following: calcium disorder or hypercalcemia, tuberculosis or granulomatous disease, metastatic bone disease, sarcoidosis, Williams syndrome, kidney disease (kidney stones, renal failure or dialysis, lupus nephritis) * Known liver disease (cirrhosis) * History of cancer other than skin cancer. * History of anorexia nervosa, bulimia or an eating disorder * Use within the past 60 days, of exogenous hormones * Type 1 or Type 2 diabetes * Known heart disease * Gastric bypass surgery * Unwilling or unable to complete study activities, e.g. collect daily urine specimens, have blood drawn, complete daily diaries, attend in person study visits 25\. Non-English speaking * Due to the complexity of daily/weekly diaries, testing and procedurerequirements, all consents, instructions and questionnaires are provided in English. Therefore, all participants must be able to able to read and speak English.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Reproductive issues are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Henry Ford Health System

    Detroit, Michigan, 48187, United States

  • NIEHS Clinical Research Unit (CRU)

    Research Triangle Park, North Carolina, 27709, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.