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Vitamin d in pregnancy fails to prevent asthma in kids

NCT ID NCT00920621

Prevention Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether giving pregnant women daily vitamin D supplements (4000 IU) could prevent asthma or recurrent wheezing in their children during the first three years of life. The trial enrolled 876 pregnant women with a personal or family history of asthma or allergies. Results showed no significant reduction in asthma or wheeze compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamin D3 (cholecalciferol)
What this could lead to
If it worked, this could point toward a simple way to reduce childhood asthma risk by giving vitamin D to pregnant women.
What could go wrong
The trial was completed but did not show a clear benefit. The results are uncertain and may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

876 people

The number who actually took part.

Start date

Sep 2009

Finished

Aug 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Personal history of asthma, eczema, allergic rhinitis or a history of asthma, eczema, allergic rhinitis in the biological father of the child * Gestational age between 10 and 18 weeks at the time of randomization * Maternal age between 18 and 39 years * Not a current smoker * English or Spanish speaking * Intent to participate for the full 4 years (through Pregnancy and then until the 3rd birthday of the child) Exclusion Criteria: * Not meeting inclusion criteria * Gestational age greater than 18 weeks * Presence of chronic medical conditions * Taking vitamin D supplements containing more than 2000 IU/day of vitamin D3 * Multiple gestation pregnancy (twins, triplets) * Pregnancy achieved by assisted reproduction techniques (e.g., IUI, IVF)

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Conditions

The condition(s) this trial relates to.

asthma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma

Contacts and locations

Locations

  • George O'Connor, MD

    Boston, Massachusetts, United States

  • Leonard Bacharier, MD

    St Louis, Missouri, United States

  • Robert Zeiger, MD

    San Diego, California, United States

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